Intraoperative Hemodynamic Instability During Unilateral Adrenalectomy for Pheochromocytoma

Trial Title: Intraoperative Hemodynamic Instability During Unilateral Adrenalectomy for Pheochromocytoma

NCT ID: NCT06062082

Condition: Pheochromocytoma
Non-Secretory Adrenal Adenoma

Conditions: Official terms:
Adenoma
Pheochromocytoma
Adrenocortical Adenoma

Conditions: Keywords:
adrenalectomy

Study type: Observational

Overall status: Recruiting

Study design:

Time perspective: Retrospective

Intervention:

Intervention type: Procedure
Intervention name: adrenalectomy
Description: laparoscopic exeresis of the adrenal gland
Arm group label: Control
Arm group label: Pheochromocytoma

Summary: Pheochromocytomas are tumors of the adrenal gland that develop from cells producing adrenaline and noradrenaline. Consequently, intraoperative blood pressure variations (hypertensive and hypotensive episodes) are characteristic of pheochromocytoma surgery, when these tumors are removed. However, recommendations for the management of these tumors are based on data essentially dating from the 1960s-1990s. Since then, anesthesia and surgery for patients with pheochromocytoma have evolved considerably, and have become more effective with time. In these circumstances, a review of the current situation is necessary. The aim of this study is to investigate the intraoperative hemodynamic changes observed in patients undergoing adrenalectomy for pheochromocytoma, comparing them with the hemodynamic profile observed in patients undergoing adrenal surgery for a pathology other than pheochromocytoma (control group).

Detailed description: Each patient included in this study underwent unilateral adrenalectomy for adrenal pathology during the inclusion period. For each patient included, intraoperative hemodynamic data were collected every 20 seconds by the monitoring system used by the anesthesia team (VitalSignsCapture v1.004 program via RS232 port). For each patient, the HI score (a clinical tool validated in two previously published articles) was calculated for the intraoperative period (time between induction of anesthesia and patient discharge from the operating room). This enabled a comparison to be made between patients operated on for pheochromocytoma (30 patients) and patients operated on for a cause other than pheochromocytoma (30 patients).

Criteria for eligibility:

Study pop:
Patients operated on for unilateral adrenal pathology by laparosocopic approach (pheochromocytoma and non-pheochromocytoma) in the department of gastrointestinal, metabolic and cancer surgery (CVMC, CHU Nancy)

Sampling method: Probability Sample
Criteria:
Inclusion Criteria: - Patients operated on for unilateral adrenal pathology by laparosocopic approach (pheochromocytoma and non-pheochromocytoma) Exclusion Criteria: - Patients operated on for unilateral adrenal pathology by laparosocopic approach (pheochromocytoma and non-pheochromocytoma) - Patients operated on for bilateral adrenal pathology

Gender: All

Minimum age: 18 Years

Maximum age: 80 Years

Healthy volunteers: No

Locations:

Facility:
Name: CHRU Nancy - Département Chirurgie Viscérale, Métabolique et Cancérologique CVMC (7ème étage)

Address:
City: Nancy
Zip: 54511
Country: France

Status: Recruiting

Contact:
Last name: Laurent Brunaud

Start date: September 1, 2015

Completion date: September 1, 2024

Lead sponsor:
Agency: Central Hospital, Nancy, France
Agency class: Other

Source: Central Hospital, Nancy, France

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06062082