Trial Title:
A Study of V940 Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer (V940-002)
NCT ID:
NCT06077760
Condition:
Non-small Cell Lung Cancer
Conditions: Official terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Pembrolizumab
Study type:
Interventional
Study phase:
Phase 3
Overall status:
Recruiting
Study design:
Allocation:
Randomized
Intervention model:
Parallel Assignment
Primary purpose:
Treatment
Masking:
Double (Participant, Investigator)
Intervention:
Intervention type:
Biological
Intervention name:
V940
Description:
IM injection
Arm group label:
V940 + Pembrolizumab
Other name:
mRNA-4157
Intervention type:
Biological
Intervention name:
Pembrolizumab
Description:
IV infusion
Arm group label:
Placebo + Pembrolizumab
Arm group label:
V940 + Pembrolizumab
Other name:
MK-3475
Other name:
KEYTRUDA®
Intervention type:
Other
Intervention name:
Placebo
Description:
IM injection
Arm group label:
Placebo + Pembrolizumab
Summary:
The goal of this study is to evaluate V940 plus pembrolizumab versus placebo plus
pembrolizumab for the adjuvant treatment of margin negative, completely resected Stage
II, IIIA, IIIB (with nodal involvement [N2]) non-small cell lung cancer (NSCLC). The
primary hypothesis is that V940 plus pembrolizumab is superior to placebo plus
pembrolizumab with respect to disease-free survival (DFS) as assessed by the
investigator.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
The main inclusion criteria include but are not limited to the following:
- Has undergone margin negative, completely resected non-small cell lung cancer
(NSCLC), and has pathological Stage II, IIIA, IIIB (N2) squamous or nonsquamous
tumor, node, metastasis (TNM) staging per American Joint Committee on Cancer (AJCC)
Eighth Edition guidelines.
- Has no evidence of disease before randomization.
- Has received at least one dose of adjuvant treatment with standard of care platinum
doublet chemotherapy.
- No more than 24 weeks have elapsed between surgical resection of curative intent and
the first dose of pembrolizumab.
- Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if
they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks
and have undetectable HBV viral load prior to randomization.
- Participants with history of hepatitis C virus (HCV) infection are eligible if HCV
viral load is undetectable at screening.
- Human immunodeficiency virus (HIV)-infected participants must have well controlled
HIV on anti-retroviral therapy (ART).
Exclusion Criteria:
The main exclusion criteria include but are not limited to the following:
- Diagnosis of small cell lung cancer (SCLC) or, for mixed tumors, presence of small
cell elements, or has a neuroendocrine tumor with large cell components or a
sarcomatoid carcinoma.
- HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric
Castleman's Disease.
- Received prior neoadjuvant therapy for their current NSCLC diagnosis.
- Received or is a candidate to receive radiotherapy for their current NSCLC
diagnosis.
- Received prior therapy with an anti-programmed cell death 1 protein (PD-1),
anti-PD-ligand 1 (L1), or anti-PD-L2 agent, or with an agent directed to another
stimulatory or coinhibitory T-cell receptor.
- Received prior systemic anticancer therapy including investigational agents within 4
weeks before randomization.
- Received a live or live-attenuated vaccine within 30 days before the first dose of
study intervention. Administration of killed vaccines are allowed.
- Has received an investigational agent or has used an investigational device within 4
weeks prior to study intervention administration.
- Diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in
dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
immunosuppressive therapy within 7 days prior to the first dose of study medication.
- Known additional malignancy that is progressing or has required active treatment
within the past 5 years.
- Active autoimmune disease that has required systemic treatment in the past 2 years.
Replacement therapy (eg, thyroxine, insulin, or physiologic corticosteroid) is
allowed.
- History of (noninfectious) pneumonitis/interstitial lung disease that required
steroids or has current pneumonitis/interstitial lung disease.
- Active infection requiring systemic therapy.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Alaska Oncology and Hematology ( Site 0039)
Address:
City:
Anchorage
Zip:
99508
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
907-257-9851
Facility:
Name:
YUMA REGIONAL MEDICAL CENTER CANCER CENTER ( Site 0020)
Address:
City:
Yuma
Zip:
85364
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
928-336-2970
Facility:
Name:
UCLA Clinical & Translational Research Center (CTRC) ( Site 0059)
Address:
City:
Los Angeles
Zip:
90095
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
310-794-7333
Facility:
Name:
University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0030)
Address:
City:
Orange
Zip:
92868
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
714-456-5533
Facility:
Name:
UCHealth Memorial Hospital-Heme Onc ( Site 0052)
Address:
City:
Colorado Springs
Zip:
80909
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
719-365-6568
Facility:
Name:
Mid Florida Hematology and Oncology Center ( Site 0014)
Address:
City:
Orange City
Zip:
32763
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
407-353-1915
Facility:
Name:
AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlandoc ( Site 0013)
Address:
City:
Orlando
Zip:
32804
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
407-303-2024
Facility:
Name:
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0012)
Address:
City:
Marietta
Zip:
30060
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
770-281-5100
Facility:
Name:
Beacon Cancer Care ( Site 0044)
Address:
City:
Post Falls
Zip:
83854
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
208-755-2408
Facility:
Name:
University of Iowa-Holden Comprehensive Cancer Center ( Site 0062)
Address:
City:
Iowa City
Zip:
52242
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
319-467-5346
Facility:
Name:
The University of Louisville, James Graham Brown Cancer Center ( Site 0037)
Address:
City:
Louisville
Zip:
40202
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
502-693-1206
Facility:
Name:
University of Michigan Clinical Trials Office ( Site 0058)
Address:
City:
Ann Arbor
Zip:
48109
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
734-615-8391
Facility:
Name:
St. Vincent Frontier Cancer Center ( Site 0043)
Address:
City:
Billings
Zip:
59102
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
406-238-6290
Facility:
Name:
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0036)
Address:
City:
Hackensack
Zip:
07601
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
551-996-5863
Facility:
Name:
Montefiore Medical Center- Montefiore Medical Park-Oncology ( Site 0080)
Address:
City:
Bronx
Zip:
10461
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
718-405-8404
Facility:
Name:
Perlmutter Cancer Center at NYU Langone Hospital - Long Island-Clinical Research Department ( Site 0
Address:
City:
Mineola
Zip:
11501
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
216-903-4153
Facility:
Name:
Laura and Isaac Perlmutter Cancer Center ( Site 0010)
Address:
City:
New York
Zip:
10016
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
216-903-4153
Facility:
Name:
Memorial Sloan Kettering Cancer Center ( Site 0029)
Address:
City:
New York
Zip:
10065
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
646-608-3761
Facility:
Name:
Stony Brook University-Cancer Center ( Site 0072)
Address:
City:
Stony Brook
Zip:
11794
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
631-444-2296
Facility:
Name:
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0063)
Address:
City:
Fargo
Zip:
58122
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
701-234-2000
Facility:
Name:
Altru Health System ( Site 0040)
Address:
City:
Grand Forks
Zip:
58201
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
701-780-5860
Facility:
Name:
University of Cincinnati Medical Center-University of Cincinnati Cancer Center ( Site 0028)
Address:
City:
Cincinnati
Zip:
45220
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
513-556-9568
Facility:
Name:
University Hospitals Cleveland Medical Center ( Site 0023)
Address:
City:
Cleveland
Zip:
44106
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
216-844-8945
Facility:
Name:
OSU Brain and Spine Hospital ( Site 0016)
Address:
City:
Columbus
Zip:
43210
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
614-293-6401
Facility:
Name:
Good Samaritan Regional Medical Center-Samaritan Pastega Regional Cancer Center ( Site 0082)
Address:
City:
Corvallis
Zip:
97330
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
541-768-4950
Facility:
Name:
Medical University of South Carolina-Hollings Cancer Center ( Site 0050)
Address:
City:
Charleston
Zip:
29425
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
843-792-9621
Facility:
Name:
Sanford Cancer Center ( Site 0075)
Address:
City:
Sioux Falls
Zip:
57104
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
605-328-8000
Facility:
Name:
Thompson Cancer Survival Center ( Site 0097)
Address:
City:
Knoxville
Zip:
37916
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
865-331-1812
Facility:
Name:
SCRI Oncology Partners ( Site 7001)
Address:
City:
Nashville
Zip:
37203
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
615-329-7274
Facility:
Name:
Inova Schar Cancer Institute ( Site 0003)
Address:
City:
Fairfax
Zip:
22031
Country:
United States
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
571-472-1380
Facility:
Name:
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 2912)
Address:
City:
Caba
Zip:
C1199ABB
Country:
Argentina
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
541149590200 8159
Facility:
Name:
Instituto Alexander Fleming ( Site 2911)
Address:
City:
Ciudad Autónoma de Buenos Aires
Zip:
C1426ANZ
Country:
Argentina
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
5491166936669
Facility:
Name:
Instituto de Investigaciones Clínicas Mar del Plata ( Site 2908)
Address:
City:
Mar del Plata
Zip:
B7600FZO
Country:
Argentina
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+5492235937663
Facility:
Name:
Fundacion Estudios Clinicos-Oncology ( Site 2907)
Address:
City:
Rosario
Zip:
S2000DEJ
Country:
Argentina
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+5493469699922
Facility:
Name:
Sanatorio Parque ( Site 2904)
Address:
City:
Rosario
Zip:
S2000DSV
Country:
Argentina
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
5493416955611
Facility:
Name:
Clinica Adventista Belgrano-Oncology ( Site 2901)
Address:
City:
Caba
Zip:
1430
Country:
Argentina
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
5491132682903
Facility:
Name:
Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0203)
Address:
City:
Melbourne
Zip:
3000
Country:
Australia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
61385595000
Facility:
Name:
St Vincent's Hospital-Oncology Clinical Trials ( Site 0202)
Address:
City:
Melbourne
Zip:
3065
Country:
Australia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
61392313155
Facility:
Name:
One Clinical Research ( Site 0200)
Address:
City:
Nedlands
Zip:
6009
Country:
Australia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
0410565868
Facility:
Name:
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi
Address:
City:
Yvoir
Zip:
5530
Country:
Belgium
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
3281422111
Facility:
Name:
Onze Lieve Vrouw Ziekenhuis Aalst-Pneumology ( Site 0604)
Address:
City:
Aalst
Zip:
9300
Country:
Belgium
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
0032499327985
Facility:
Name:
VITAZ ( Site 0600)
Address:
City:
Sint-Niklaas
Zip:
9100
Country:
Belgium
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
3237602327
Facility:
Name:
CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA-Pesquisa Clínica ( Site 3007)
Address:
City:
Fortaleza
Zip:
60336232
Country:
Brazil
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
5585991372979
Facility:
Name:
Liga Norte Riograndense Contra o Câncer ( Site 3001)
Address:
City:
Natal
Zip:
59062-000
Country:
Brazil
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
558440095595
Facility:
Name:
Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 3003)
Address:
City:
Porto Alegre
Zip:
90050-170
Country:
Brazil
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+5551997292010
Facility:
Name:
Hospital Nossa Senhora da Conceição ( Site 3002)
Address:
City:
Porto Alegre
Zip:
91350-200
Country:
Brazil
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+5551993590437
Facility:
Name:
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 3004)
Address:
City:
Barretos
Zip:
14784400
Country:
Brazil
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
33216600
Facility:
Name:
Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 3013)
Address:
City:
São José do Rio Preto
Zip:
15090000
Country:
Brazil
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
11997722237
Facility:
Name:
Instituto Nacional de Câncer - INCA ( Site 3000)
Address:
City:
Rio de Janeiro
Zip:
20230-130
Country:
Brazil
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+552132076564
Facility:
Name:
Hospital Samaritano De Sao Paulo ( Site 3006)
Address:
City:
Sao Paulo
Zip:
01232-010
Country:
Brazil
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+5511944716385
Facility:
Name:
ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 3005)
Address:
City:
Sao Paulo
Zip:
01246-000
Country:
Brazil
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
551138932615
Facility:
Name:
William Osler Health System ( Site 0101)
Address:
City:
Brampton
Zip:
L6R 3J7
Country:
Canada
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
9054942120
Facility:
Name:
Centre Hospitalier de l'Université de Montréal ( Site 0104)
Address:
City:
Montréal
Zip:
H2X 3E4
Country:
Canada
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
5148908000ext26832
Facility:
Name:
McGill University Health Centre ( Site 0100)
Address:
City:
Montréal
Zip:
H4A 3J1
Country:
Canada
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
514934193443050
Facility:
Name:
Orlandi Oncologia-Oncology ( Site 3102)
Address:
City:
Santiago
Zip:
7500713
Country:
Chile
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
56992214787
Facility:
Name:
FALP-UIDO ( Site 3100)
Address:
City:
Santiago
Zip:
7500921
Country:
Chile
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
56224457254
Facility:
Name:
Pontificia Universidad Catolica de Chile-Centro del Cáncer ( Site 3104)
Address:
City:
Santiago
Zip:
8330032
Country:
Chile
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+56963413803
Facility:
Name:
Bradfordhill-Clinical Area ( Site 3103)
Address:
City:
Santiago
Zip:
8420383
Country:
Chile
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+56998744662
Facility:
Name:
ONCOCENTRO APYS ( Site 3105)
Address:
City:
Viña del Mar
Zip:
2520598
Country:
Chile
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+56992369820
Facility:
Name:
CIMCA ( Site 3300)
Address:
City:
San José
Zip:
10103
Country:
Costa Rica
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
50683893636
Facility:
Name:
ICIMED ( Site 3301)
Address:
City:
San Jose
Zip:
10108
Country:
Costa Rica
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
506 88317449
Facility:
Name:
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0700)
Address:
City:
Brno
Zip:
656 53
Country:
Czechia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
420543134008
Facility:
Name:
Nemocnice AGEL Ostrava - Vitkovice a.s.-Plicni odd ( Site 0702)
Address:
City:
Ostrava
Zip:
703 00
Country:
Czechia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
00420 595 633 400
Facility:
Name:
Fakultni nemocnice Olomouc-Klinika plicnich nemoci a tuberkulozy ( Site 0701)
Address:
City:
Olomouc
Zip:
779 00
Country:
Czechia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
420588445657
Facility:
Name:
Vseobecna fakultni nemocnice v Praze ( Site 0703)
Address:
City:
Praha 2
Zip:
12808
Country:
Czechia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
420602211846
Facility:
Name:
Rigshospitalet ( Site 0801)
Address:
City:
Copenhagen
Zip:
2100
Country:
Denmark
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
4535451148
Facility:
Name:
Odense Universitetshospital ( Site 0800)
Address:
City:
Odense C
Zip:
5000
Country:
Denmark
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
4561707362
Facility:
Name:
North Estonia Medical Centre Foundation-Chemotherapy ( Site 0901)
Address:
City:
Tallinn
Zip:
13419
Country:
Estonia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
3726171792
Facility:
Name:
Tartu University Hospital-Radiotherapy and oncology ( Site 0900)
Address:
City:
Tartu
Zip:
50406
Country:
Estonia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
3725513443
Facility:
Name:
Tampereen yliopistollinen sairaala-Oncology ( Site 1001)
Address:
City:
Tampere
Zip:
33520
Country:
Finland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
00358331163254
Facility:
Name:
Vaasan Keskussairaala-Department of Clinical Oncology ( Site 1004)
Address:
City:
Vaasa
Zip:
65130
Country:
Finland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
35862136981
Facility:
Name:
Oulun yliopistollinen sairaala-Oncology and Hematology ( Site 1003)
Address:
City:
Oulu
Zip:
90220
Country:
Finland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
35883153789
Facility:
Name:
Turku University Hospital-The Department of Pulmonary Medicine ( Site 1000)
Address:
City:
Turku
Zip:
20520
Country:
Finland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
35823138709
Facility:
Name:
Nouvel Hôpital Civil (NHC)-Service de pneumologie ( Site 1100)
Address:
City:
Strasbourg
Zip:
67091
Country:
France
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
0033369550644
Facility:
Name:
CHU Bordeaux Haut-Leveque ( Site 1106)
Address:
City:
Pessac
Zip:
33600
Country:
France
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
0557656338
Facility:
Name:
Assistance Publique Hôpitaux de Marseille - Hôpital Nord ( Site 1108)
Address:
City:
Marseille
Zip:
13915
Country:
France
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
33491324400
Facility:
Name:
Hôpital Arnaud de Villeneuve - CHU Montpellier ( Site 1102)
Address:
City:
Montpellier
Zip:
34090
Country:
France
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+33 467330759
Facility:
Name:
Institut de Cancérologie de l'Ouest ( Site 1101)
Address:
City:
ANGERS cedex 02
Zip:
49055
Country:
France
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
33241352700
Facility:
Name:
CHU GABRIEL MONTPIED ( Site 1105)
Address:
City:
Clermont-Ferrand
Zip:
63000
Country:
France
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
04 73 75 16 49
Facility:
Name:
Hopitaux Universitaires Paris Centre-Hopital Cochin ( Site 1104)
Address:
City:
Paris
Zip:
75014
Country:
France
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
33158413091
Facility:
Name:
Klinikum Esslingen-Klinik für Kardiologie und Pneumologie ( Site 1201)
Address:
City:
Esslingen
Zip:
73730
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+49 71131032402
Facility:
Name:
Klinikverbund Allgäu gGmbH ( Site 1205)
Address:
City:
Kempten
Zip:
87439
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+49 8323 910 8171
Facility:
Name:
Augusta-Kranken-Anstalt ( Site 1213)
Address:
City:
Bochum
Zip:
44791
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
004915159884743
Facility:
Name:
Gemeinschaftspraxis für Hämatologie und Onkologie Münster ( Site 1202)
Address:
City:
Münster
Zip:
48153
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
492519764537
Facility:
Name:
Brüderkrankenhaus St. Josef Paderborn-Klinik für Hämatologie und Onkologie ( Site 1214)
Address:
City:
Paderborn
Zip:
33098
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
004952517021425
Facility:
Name:
SRH Wald-Klinikum Gera-Lungenkrebszentrum ( Site 1200)
Address:
City:
Gera
Zip:
07548
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
493658287758
Facility:
Name:
Helios Klinikum Emil von Behring Berlin-Zehlendorf-Lungenklinik Heckeshorn ( Site 1208)
Address:
City:
Berlin
Zip:
14165
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
00493081021447
Facility:
Name:
Errikos Dunant Hospital Center-Fourth Department of Oncology and Clinical Trials Unit ( Site 1301)
Address:
City:
Athens
Zip:
115 26
Country:
Greece
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+306983519989
Facility:
Name:
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol
Address:
City:
Athens
Zip:
115 27
Country:
Greece
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
302107700220
Facility:
Name:
European Interbalkan Medical Center-Oncology Department ( Site 1302)
Address:
City:
Thessaloniki
Zip:
57001
Country:
Greece
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
306942608228
Facility:
Name:
Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 1401)
Address:
City:
Kecskemét
Zip:
6000
Country:
Hungary
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+3676516719
Facility:
Name:
Pécsi Tudományegyetem Klinikai Központ-Onkoterápiás Intézet ( Site 1402)
Address:
City:
Pecs
Zip:
7624
Country:
Hungary
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
36205264756
Facility:
Name:
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz - Pulmonologia Osztaly ( Site 1404)
Address:
City:
Gyor
Zip:
9024
Country:
Hungary
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+36 30 975 8356
Facility:
Name:
Reformatus Pulmonologiai Centrum ( Site 1405)
Address:
City:
Törökbálint
Zip:
2045
Country:
Hungary
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
36307005601
Facility:
Name:
Somogy Varmegyei Kaposi Mor Oktato Korhaz -Onkologiai Kozpont ( Site 1407)
Address:
City:
Kaposvár
Zip:
7400
Country:
Hungary
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
36203782777
Facility:
Name:
Tallaght University Hospital ( Site 3903)
Address:
City:
Dublin
Zip:
D24 NR0A
Country:
Ireland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
0035314144299
Facility:
Name:
CRO-IRCCS-Clinical Oncology ( Site 1510)
Address:
City:
Aviano
Zip:
33081
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
390434659294
Facility:
Name:
P.O. "S. Maria della Misericordia" Azienda Sanitaria Univers-Oncology Department ( Site 1506)
Address:
City:
Udine
Zip:
33100
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
390432559330
Facility:
Name:
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1504)
Address:
City:
Milan
Zip:
20133
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
390223903829
Facility:
Name:
ASST Grande Ospedale Metropolitano Niguarda-Oncologia Falck ( Site 1511)
Address:
City:
Milan
Zip:
20162
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
390264442291
Facility:
Name:
A.O.R.N. Ospedale dei Colli - Monaldi V.-U.O.C Pneumologia Oncologica DH PNL ONC ( Site 1508)
Address:
City:
Naples
Zip:
80131
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
390817064300
Facility:
Name:
Instituto Tumori Giovanni Paolo II-SSD Oncologia Medica per la Patologia Toracica ( Site 1507)
Address:
City:
Bari
Zip:
70124
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
390805555442
Facility:
Name:
POLICLINICO "G. RODOLICO"-UOC Oncologia Medica ( Site 1503)
Address:
City:
Catania
Zip:
95123
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+390953782426
Facility:
Name:
AO Santa Maria della Misericordia-Oncology Department ( Site 1501)
Address:
City:
Perugia
Zip:
06132
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+390755782661
Facility:
Name:
Azienda Ospedaliero Universitaria Maggiore della Carità ( Site 1502)
Address:
City:
Novara
Zip:
28100
Country:
Italy
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
393213733989
Facility:
Name:
Chungbuk National University Hospital-Internal medicine ( Site 0402)
Address:
City:
Cheongju-si
Zip:
28644
Country:
Korea, Republic of
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
82432696015
Facility:
Name:
National Cancer Center-Lung Cancer Center ( Site 0403)
Address:
City:
Goyang-si
Zip:
10408
Country:
Korea, Republic of
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
82319201694
Facility:
Name:
Seoul National University Bundang Hospital-Medical Oncology ( Site 0404)
Address:
City:
Seongnam
Zip:
13620
Country:
Korea, Republic of
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
82317877071
Facility:
Name:
The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 0406)
Address:
City:
Suwon-si
Zip:
16247
Country:
Korea, Republic of
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
82312498153
Facility:
Name:
Keimyung University Dongsan Hospital CRC room 1 ( Site 0407)
Address:
City:
Daegu
Zip:
42601
Country:
Korea, Republic of
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
82532586671
Facility:
Name:
Seoul National University Hospital ( Site 0400)
Address:
City:
Seoul
Zip:
03080
Country:
Korea, Republic of
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+821027324635
Facility:
Name:
Asan Medical Center-Department of Oncology ( Site 0405)
Address:
City:
Seoul
Zip:
05505
Country:
Korea, Republic of
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
82230103215
Facility:
Name:
Samsung Medical Center ( Site 0401)
Address:
City:
Seoul
Zip:
06351
Country:
Korea, Republic of
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
82234103438
Facility:
Name:
RIGA EAST UNIVERSITY HOSPITAL ,Oncology Centre of Latvia ( Site 1600)
Address:
City:
Riga
Zip:
LV1079
Country:
Latvia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+37167539160
Facility:
Name:
Hospital of Lithuanian University of Health Sciences Kauno klinikos-Pulmonology ( Site 1701)
Address:
City:
Kaunas
Zip:
50161
Country:
Lithuania
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
37037326457
Facility:
Name:
National Cancer Institute-Department of Thoracic Surgery and Oncology ( Site 1700)
Address:
City:
Vilnius
Zip:
08660
Country:
Lithuania
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
37060891491
Facility:
Name:
University Malaya Medical Centre ( Site 3502)
Address:
City:
Lembah Pantai
Zip:
59100
Country:
Malaysia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
60379492299
Facility:
Name:
National Cancer Institute-Radiotherapy and Oncology ( Site 3506)
Address:
City:
Putrajaya
Zip:
62250
Country:
Malaysia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
123304499
Facility:
Name:
Hospital Tengku Ampuan Afzan ( Site 3504)
Address:
City:
Kuantan
Zip:
25100
Country:
Malaysia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+60192896000
Facility:
Name:
Hospital Pulau Pinang ( Site 3505)
Address:
City:
George Town
Zip:
10450
Country:
Malaysia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
01641569261
Facility:
Name:
Sarawak General Hospital ( Site 3500)
Address:
City:
Kuching
Zip:
93586
Country:
Malaysia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
6082276666
Facility:
Name:
New Zealand Clinical Research (Christchurch) ( Site 0300)
Address:
City:
Christchurch
Zip:
8011
Country:
New Zealand
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
64278360830
Facility:
Name:
Harbour Cancer & Wellness ( Site 0301)
Address:
City:
Auckland
Zip:
1023
Country:
New Zealand
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
6421783590
Facility:
Name:
Akershus Universitetssykehus-Avdeling for lungesykdommer ( Site 1900)
Address:
City:
Lørenskog
Zip:
1478
Country:
Norway
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
004746261495
Facility:
Name:
Drammen Sykehus, Vestre Viken HF ( Site 1903)
Address:
City:
Drammen
Zip:
3004
Country:
Norway
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
4799723094
Facility:
Name:
Stavanger Universitetssykehus ( Site 1901)
Address:
City:
Stavanger
Zip:
4011
Country:
Norway
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+4792216765
Facility:
Name:
CARDINAL SANTOS MEDICAL CENTER-Research Room ( Site 3601)
Address:
City:
San Juan City, Metro Manila
Zip:
1502
Country:
Philippines
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
639176227242
Facility:
Name:
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2003)
Address:
City:
Bydgoszcz
Zip:
85-796
Country:
Poland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
48501446778
Facility:
Name:
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier
Address:
City:
Warszawa
Zip:
02-781
Country:
Poland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+48225463066
Facility:
Name:
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 2001)
Address:
City:
Przemysl
Zip:
37-700
Country:
Poland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
661957237
Facility:
Name:
Bialostockie Centrum Onkologii ( Site 2005)
Address:
City:
Bialystok
Zip:
15-027
Country:
Poland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+48856646888
Facility:
Name:
Uniwersyteckie Centrum Kliniczne ( Site 2013)
Address:
City:
Gdansk
Zip:
80-952
Country:
Poland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+48583492270
Facility:
Name:
Warmińsko - Mazurskie Centrum Chorób Płuc w Olsztynie-Oddzial Onkologii z Pododdzialem Chemioterapii
Address:
City:
Olsztyn
Zip:
10-357
Country:
Poland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+48791789626
Facility:
Name:
Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz
Address:
City:
Poznan
Zip:
60-569
Country:
Poland
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
48785216586
Facility:
Name:
Unidade Local de Saude de Santa Maria - Hospital Pulido Valente ( Site 2703)
Address:
City:
Lisbon
Zip:
1769-001
Country:
Portugal
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
351217548085
Facility:
Name:
Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 2702)
Address:
City:
Porto
Zip:
4200-072
Country:
Portugal
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+351225084000
Facility:
Name:
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica ( Site 2202)
Address:
City:
Banska Bystrica
Zip:
97517
Country:
Slovakia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
00421915831411
Facility:
Name:
Univerzitná nemocnica Bratislava - Nemocnica Ružinov ( Site 2201)
Address:
City:
Bratislava
Zip:
826 06
Country:
Slovakia
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
00421903752376
Facility:
Name:
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2401)
Address:
City:
L Hospitalet
Zip:
08908
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
34932607283
Facility:
Name:
HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA-Medical Oncology ( Site 2403)
Address:
City:
Majadahonda
Zip:
28222
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
34911917759
Facility:
Name:
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 2402)
Address:
City:
Pozuelo de Alarcon
Zip:
28223
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
34914521987
Facility:
Name:
Hospital Quirón Málaga ( Site 2405)
Address:
City:
Málaga
Zip:
29004
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
00349422033350000
Facility:
Name:
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2400)
Address:
City:
Barcelona
Zip:
08035
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
34934894158
Facility:
Name:
Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2404)
Address:
City:
Sevilla
Zip:
41009
Country:
Spain
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
34955008932
Facility:
Name:
Changhua Christian Hospital ( Site 0504)
Address:
City:
Changhua County
Zip:
50006
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Sheng-Hao Lin
Phone:
886472385957791
Facility:
Name:
National Taiwan University Cancer Center (NTUCC) ( Site 0500)
Address:
City:
Taipei City
Zip:
106
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Chih-Hsin Yang
Phone:
88622312345667511
Facility:
Name:
National Taiwan University Hospital - Hsinchu branch ( Site 0501)
Address:
City:
Hsinchu
Zip:
300
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Jih-Hsiang Lee
Phone:
886223368239
Facility:
Name:
Taichung Veterans General Hospital-Chest ( Site 0503)
Address:
City:
Taichung
Zip:
40705
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Tsung-Ying Yang
Phone:
8864235925253218
Facility:
Name:
National Cheng Kung University Hospital-Clinical Trial Center ( Site 0505)
Address:
City:
Tainan
Zip:
704
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Chien-Chung Lin
Phone:
+886-2353535-3117
Facility:
Name:
National Taiwan University Hospital-Oncology ( Site 0506)
Address:
City:
Taipei
Zip:
10002
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Chih-Hsin Yang
Phone:
88622312345667511
Facility:
Name:
Taipei Medical University Hospital ( Site 0502)
Address:
City:
Taipei
Zip:
110301
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Chao-Hua Chiu
Phone:
886227372181-3599
Facility:
Name:
Hacettepe Universite Hastaneleri-oncology hospital ( Site 2100)
Address:
City:
Ankara
Zip:
06230
Country:
Turkey
Status:
Recruiting
Contact:
Last name:
Study Coordinator
Phone:
+905334318506
Start date:
December 6, 2023
Completion date:
December 21, 2035
Lead sponsor:
Agency:
Merck Sharp & Dohme LLC
Agency class:
Industry
Collaborator:
Agency:
ModernaTX, Inc.
Agency class:
Industry
Source:
Merck Sharp & Dohme LLC
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06077760
http://www.merckclinicaltrials.com
https://trialstransparency.merckclinicaltrials.com/Study.aspx?id=V940-002&&kw=V940-002
