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Trial Title:
Microbiota and Metabolomics of Intestinal Type of Gastric Cancer
NCT ID:
NCT06079554
Condition:
Gastric Cancer
Conditions: Official terms:
Stomach Neoplasms
Study type:
Observational [Patient Registry]
Overall status:
Recruiting
Study design:
Time perspective:
Prospective
Summary:
Compare with the gastric cavity without cancerous transformation in atrophic gastritis,
analyze the microbiota and metabolomics changes in intestinal type of gastric cancer
under the background of atrophic gastritis, and explore the relevant mechanisms.
Detailed description:
This study adopts a prospective cohort study. The expected recruitment time for all
participants is 6 months, and all cases are cases who would receive magnifying endoscopy
examination. The extent of atrophy and the presence of early gastric cancer are
determined under magnifying endoscopy. Cases are chose into the gastric cancer group and
atrophic gastritis group in a 1:1 ratio. There are 16 cases of intestinal type of gastric
cancer under the background of atrophic gastritis, and 16 cases of atrophic gastritis
without gastric cancer matched according to gender, age, and degree of gastric atrophy,
totaling 32 cases. Analyze the characteristics of early gastric cancer under endoscopy,
investigate the changes in microbiota and metabolomics of intestinal type of gastric
cancer under the background of atrophic gastritis, and explore the relevant mechanisms.
Criteria for eligibility:
Study pop:
We underwent magnifying staining endoscopy examination in our hospital and diagnosed
cases of atrophic gastritis with or without gastric cancer under endoscopy.
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- •Intestinal type of gastric cancer or atrophic gastritis
- Underwent Endoscopic submucosal dissection（ESD）
Exclusion Criteria:
- • have simultaneously other cancer
- have severe systemic inflammatory disease ,serious illness such as diabetes,
chronic lung diseases
Gender:
All
Minimum age:
18 Years
Maximum age:
80 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
the First Hospital of Jilin University
Address:
City:
Chang chun
Zip:
130021
Country:
China
Status:
Recruiting
Contact:
Last name:
Dong Yang, Master
Start date:
March 31, 2024
Completion date:
August 30, 2025
Lead sponsor:
Agency:
Jilin University
Agency class:
Other
Source:
Jilin University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06079554
