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Trial Title:
Appendectomy and Colorectal Cancer
NCT ID:
NCT06091137
Condition:
Colorectal Cancer
Appendicitis
Conditions: Official terms:
Appendicitis
Colorectal Neoplasms
Study type:
Observational
Overall status:
Active, not recruiting
Study design:
Time perspective:
Retrospective
Summary:
Colorectal cancer (CRC) is one of the most common cancer worldwide. Initiation and
progression of CRC involve complex interactions among genetic, epigenetic and
environmental factors. Given that hereditary and familial CRC only accounts for 2% to 5%
of cases, environmental factors are the key triggers of CRC. Emerging evidence has
indicated that gut microbes are an important environmental factor promoting CRC
development. Gut dysbiosis has been shown to promote colorectal carcinogenesis in mice.
Several individual bacterial species, such as the enterotoxigenic Bacteroides fragilis
(ETBF), Fusobacterium nucleatum and Peptostreptococcus anaerobius, could exert
carcinogenic effects by inducing direct DNA damage, oxidative damage and activating
oncogenic signaling pathways. Recent studies have shown that the appendix plays an
important role in maintaining homeostasis and biodiversity of gut microbiome by providing
an ideal ecological niche for commensal bacteria and production of immunoglobulin A.
Considering the key role of microorganisms in gastrointestinal pathophysiology, absence
of appendix may result in disruption of microbiome homeostasis, which could potentially
influence the risk of developing CRC. In terms of epidemiological evidence, the
association of appendectomy with the risk of CRC development has been controversial, and
to date no consensus has been attained. Although gut microorganisms could be a crucial
pivot between appendectomy and risk of subsequent CRC development, the direct
contribution of appendectomy and the underlying mechanisms are still largely unexplored.
In this study, we aim to study
1. the association between appendectomy and colorectal cancer, and
2. the role of appendectomy in CRC risk through causing gut microbial dysbiosis.
Criteria for eligibility:
Study pop:
60000 appendectomy cases and 120000 controls
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Individuals underwent appendectomy from January 2000 to December 2020
Exclusion Criteria:
1. patients with the age ≤18 years at enrollment;
2. Patients with any malignant diseases or inflammatory bowel disease history before
enrollment;
3. Patients with hereditary syndromes of colorectal adenomas or polyps (familial
adenomatous polyposis, Lynch syndrome, etc.);
4. Patients that underwent appendectomy for appendiceal neoplasms.
Gender:
All
Minimum age:
N/A
Maximum age:
N/A
Locations:
Facility:
Name:
Institute of Digestive Disease, The Chinese University of Hong Kong
Address:
City:
Sha Tin
Zip:
00000
Country:
Hong Kong
Start date:
June 1, 2022
Completion date:
May 31, 2025
Lead sponsor:
Agency:
Chinese University of Hong Kong
Agency class:
Other
Source:
Chinese University of Hong Kong
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06091137
