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Trial Title:
Gene Expression Profiling in a Validation Cohort of Locally Advanced and Recurrent/Metastatic Salivary Gland Cancers
NCT ID:
NCT06091878
Condition:
Salivary Gland Cancer
Conditions: Official terms:
Salivary Gland Neoplasms
Study type:
Observational
Overall status:
Not yet recruiting
Study design:
Time perspective:
Retrospective
Intervention:
Intervention type:
Other
Intervention name:
Observation
Description:
Observational study, no intervention
Arm group label:
Cohort 1
Summary:
The INDAGA-UK trial is a retrospective, multi-centre observational study in participants
with locally advanced and recurrent salivary gland to investigate t its molecular
profiling, and to explore new prognostic and druggable markers. We will analyse samples
and data from patients diagnosed with salivary gland cancer from 2013 - 2023. Subject and
sample identification will occur over a 12-month period. Samples and data will be
analysed over the next 12 months prior to study end.
Criteria for eligibility:
Study pop:
Participants with a salivary gland cancer diagnosis
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
1. Aged over 18
2. Histological diagnosis of salivary gland cancer (SGCs)
3. Availability of archival tissue (acceptable after 2013 up to present)
4. Ability to give informed consent (if applicable)* for retrieving histological
specimen and preform molecular analysis *De-identified archival tissue from deceased
patients will be collected as part of the study once REC approval is in place, if
the patient was alive when the samples were taken and they are not part of the NHS
opt out scheme.
Exclusion Criteria:
1. Different H&N cancer of other histology
2. Thyroid cancers
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Start date:
September 1, 2024
Completion date:
January 31, 2026
Lead sponsor:
Agency:
Royal Marsden NHS Foundation Trust
Agency class:
Other
Source:
Royal Marsden NHS Foundation Trust
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06091878
