Trial Title:
A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment
NCT ID:
NCT06105632
Condition:
Advanced or Metastatic Breast Cancer
Conditions: Official terms:
Breast Neoplasms
Everolimus
Fulvestrant
Exemestane
Conditions: Keywords:
Estrogen receptor positive [ER(+)]
Human epidermal growth factor receptor 2 negative [HER(-)]
ER(+)/HER2(-)
Advanced Breast Cancer
Breast tumor
Breast cancer
fulvestrant
everolimus
exemestane
Partial Response+ (PR+)
Metastatic breast cancer
Hormone Therapy
Hormone positive breast cancer
Recurrent breast cancer
HR+
HER2-negative
Relapse
Recurrent
Second line treatment.
Study type:
Interventional
Study phase:
Phase 3
Overall status:
Recruiting
Study design:
Allocation:
Randomized
Intervention model:
Parallel Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
PF-07220060 CDK4 inhibitor
Description:
Experimental
Arm group label:
Arm A
Intervention type:
Drug
Intervention name:
Fulvestrant
Description:
Experimental and Active comparator
Arm group label:
Arm A
Arm group label:
Arm B
Intervention type:
Drug
Intervention name:
Everolimus
Description:
Active Comparator
Arm group label:
Arm B
Intervention type:
Drug
Intervention name:
Exemestane
Description:
Active Comparator
Arm group label:
Arm B
Summary:
The purpose of this study is to learn about the safety and how effective the study
medicine (PF-07220060) plus fulvestrant is compared to the study doctor's choice of
treatment in people with advanced or metastatic breast cancer. Advanced cancer is the one
that is unlikely to be cured or taken care of with treatment. Metastatic cancer is the
one that has spread to other parts of the body.
This study is seeking female and male participants who:
- are 18 years of age or older;
- are hormone receptor (HR)-positive and human epidermal growth factor receptor 2
(HER2)-negative;
- have advanced or metastatic breast cancer after taking other treatments before this
study;
- have not taken or need to take medications that are not allowed by the study
protocol;
- do not have any medical or mental conditions that may increase the risk of study
participation.
Half of the participants will take PF-07220060 two times daily by mouth along with
fulvestrant. Fulvestrant will be given as a shot into the muscle. The other half will
take the study doctor's choice of treatment which can either be:
- Fulvestrant alone taken as shot into the muscle.
- Everolimus along with exemestane taken once daily by mouth.
This study will compare the experiences of participants receiving the study medicine plus
fulvestrant to those who are receiving the study doctor's choice of treatment. This will
help decide if the study medicine is safe and effective.
Participants will receive study treatment and/or will be in the study until:
- imaging scans (such as an MRI and/or CT) show that their cancer is getting worse.
- the study doctor thinks the participant is no longer benefitting from the study
medicine.
- has side effects that become too severe. A side effect is a reaction (expected or
unexpected) to a medicine or treatment you take.
- the participant chooses to stop taking part.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Histological confirmation of breast cancer with evidence of locally advanced or
metastatic disease, which is not amenable to surgical resection or radiation therapy
with curative intent.
- Documented estrogen receptor (ER) and/or progesterone receptor (PR)- positive tumor
- Documented HER2-negative tumor
- Able to provide a sufficient amount of representative formalin fixed, paraffin
embedded (FFPE) tumor tissue specimen.
- Must have received CDK4/6i plus NSAI defined per study protocol. There must be
documented PD during or after CDK4/6i treatment.
- Measurable disease or non-measurable bone only disease as defined by RECIST version
1.1.
- Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) ≤2.
Exclusion Criteria:
- Any medical or psychiatric condition that may increase the risk of study
participation or make the participant inappropriate for the study.
- In visceral crisis at risk of immediately life-threatening complications in the
short term.
- Known active uncontrolled or symptomatic central nervous system metastases,
carcinomatous meningitis, or leptomeningeal disease.
- Prior treatment with any of the following:
- Everolimus or investigational anti-cancer agents in any setting
- Prior chemotherapy in the advanced setting
- Radiation within 2 weeks of randomization
- Current use or anticipated need for any prohibited food, supplements or concomitant
medication(s) (ie, other anti-cancer therapies, other endocrine therapies, growth
factors, chronic systemic corticosteroids, strong cytochrome P450 3A4/5 [CYP3A4/5]
or uridine 5' diphosphate-glucuronosyltransferase 2B7 [UGT2B7] inhibitors and
inducers, direct oral anticoagulants, proton pump inhibitors).
- Inadequate renal function, hepatic dysfunction, or hematologic abnormalities.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Highlands Oncology Group
Address:
City:
Fayetteville
Zip:
72703
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Highlands Oncology Group
Address:
City:
Rogers
Zip:
72758
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Highlands Oncology Group
Address:
City:
Springdale
Zip:
72762
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
UCSF - John Muir Health Cancer Center Berkeley
Address:
City:
Berkeley
Zip:
94702
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Washington Hospital Healthcare System
Address:
City:
Fremont
Zip:
94538
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Hoag Health Center Irvine
Address:
City:
Irvine
Zip:
92618
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Hoag Hospital Irvine
Address:
City:
Irvine
Zip:
92618
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Eisenhower George and Julia Argyros Health Center
Address:
City:
La Quinta
Zip:
92253
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Keck Hospital of USC
Address:
City:
Los Angeles
Zip:
90033
Country:
United States
Status:
Recruiting
Facility:
Name:
Los Angeles General Medical Center
Address:
City:
Los Angeles
Zip:
90033
Country:
United States
Status:
Recruiting
Facility:
Name:
USC/Norris Comprehensive Cancer Center
Address:
City:
Los Angeles
Zip:
90033
Country:
United States
Status:
Recruiting
Facility:
Name:
Hoag Memorial Hospital Presbyterian
Address:
City:
Newport Beach
Zip:
92663
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Eisenhower Health Center at South Palm Canyon
Address:
City:
Palm Springs
Zip:
92262
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Keck Medical Center of USC Pasadena
Address:
City:
Pasadena
Zip:
91105
Country:
United States
Status:
Recruiting
Facility:
Name:
Eisenhower Medical Center
Address:
City:
Rancho Mirage
Zip:
92270
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Zuckerberg San Francisco General Hospital and Trauma Center
Address:
City:
San Francisco
Zip:
94110
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
UCSF Medical Center at Mission Bay
Address:
City:
San Francisco
Zip:
94158
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
UCSF Cancer Center San Mateo
Address:
City:
San Mateo
Zip:
94402
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Chronic Disease Clinical Research Center (CDCRC)
Address:
City:
Torrance
Zip:
90502
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Clinical and Translational Research Center
Address:
City:
Torrance
Zip:
90502
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Address:
City:
Torrance
Zip:
90502
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Diagnostic and Wellness Center
Address:
City:
Torrance
Zip:
90509
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Harbor UCLA
Address:
City:
Torrance
Zip:
90509
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Saint Vincent's Medical Center (SVMC)
Address:
City:
Bridgeport
Zip:
06606
Country:
United States
Status:
Recruiting
Facility:
Name:
Danbury Hospital
Address:
City:
Danbury
Zip:
06810
Country:
United States
Status:
Recruiting
Facility:
Name:
Hartford Hospital (HH)
Address:
City:
Hartford
Zip:
06102
Country:
United States
Status:
Recruiting
Facility:
Name:
MidState Medical Center (MMC)
Address:
City:
Meriden
Zip:
06451
Country:
United States
Status:
Recruiting
Facility:
Name:
Hartford Healthcare
Address:
City:
New Britain
Zip:
06053
Country:
United States
Status:
Recruiting
Facility:
Name:
Norwalk Hospital
Address:
City:
Norwalk
Zip:
06856
Country:
United States
Status:
Recruiting
Facility:
Name:
Hartford HealthCare Cancer Institute at The Hospital of Central Connecticut, Medical Arts Center
Address:
City:
Plainville
Zip:
06062
Country:
United States
Status:
Recruiting
Facility:
Name:
Georgetown University Medical Center
Address:
City:
Washington
Zip:
20007
Country:
United States
Status:
Recruiting
Facility:
Name:
MedStar Washington Hospital Center
Address:
City:
Washington
Zip:
20010
Country:
United States
Status:
Recruiting
Facility:
Name:
Summit Cancer Care DBA Candler Medical Oncology Practice
Address:
City:
Savannah
Zip:
31405
Country:
United States
Status:
Recruiting
Facility:
Name:
Summit Cancer Care, PC
Address:
City:
Savannah
Zip:
31405
Country:
United States
Status:
Recruiting
Facility:
Name:
Advocate Good Shepherd Hospital
Address:
City:
Barrington
Zip:
60010
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Northwestern Memorial Hospital
Address:
City:
Chicago
Zip:
60611
Country:
United States
Status:
Recruiting
Facility:
Name:
NorthShore University HealthSystem
Address:
City:
Chicago
Zip:
60625
Country:
United States
Status:
Recruiting
Facility:
Name:
Advocate Illinois Masonic Medical Center
Address:
City:
Chicago
Zip:
60657
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Advocate Good Samaritan Hospital
Address:
City:
Downers Grove
Zip:
60515
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
NorthShore University HealthSystem
Address:
City:
Evanston
Zip:
60201
Country:
United States
Status:
Recruiting
Facility:
Name:
Ascension Illinois - Evanston Infusion Center
Address:
City:
Evanston
Zip:
60202
Country:
United States
Status:
Recruiting
Facility:
Name:
NorthShore University HealthSystem
Address:
City:
Glenview
Zip:
60026
Country:
United States
Status:
Recruiting
Facility:
Name:
NorthShore University HealthSystem
Address:
City:
Highland Park
Zip:
60035
Country:
United States
Status:
Recruiting
Facility:
Name:
AMG Libertyville
Address:
City:
Libertyville
Zip:
60048
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Advocate Christ Medical Center
Address:
City:
Oak Lawn
Zip:
60453
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Advocate Lutheran General Hospital
Address:
City:
Park Ridge
Zip:
60068
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Ascension Illinois-Skokie Infusion Center
Address:
City:
Skokie
Zip:
60077
Country:
United States
Status:
Recruiting
Facility:
Name:
Orchard Healthcare Research Inc.
Address:
City:
Skokie
Zip:
60077
Country:
United States
Status:
Recruiting
Facility:
Name:
University of Iowa Health Care Cancer Services Quad Cities
Address:
City:
Bettendorf
Zip:
52722
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
University of Iowa Hospitals & Clinics
Address:
City:
Iowa City
Zip:
52242
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Anne Arundel Medical Center
Address:
City:
Annapolis
Zip:
21401
Country:
United States
Status:
Recruiting
Facility:
Name:
The University of Mississippi Medical Center
Address:
City:
Jackson
Zip:
39213
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
The University of Mississippi Medical Center
Address:
City:
Jackson
Zip:
39216
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Intermountain Health St. Vincent Regional Hospital
Address:
City:
Billings
Zip:
59101
Country:
United States
Status:
Recruiting
Facility:
Name:
St. Vincent Frontier Cancer Center
Address:
City:
Billings
Zip:
59102
Country:
United States
Status:
Recruiting
Facility:
Name:
Cancer Care Specialists
Address:
City:
Reno
Zip:
89511
Country:
United States
Status:
Recruiting
Facility:
Name:
Hackensack University Medical Center
Address:
City:
Hackensack
Zip:
07601
Country:
United States
Status:
Recruiting
Facility:
Name:
John Theurer Cancer Center at Hackensack University Medical Center
Address:
City:
Hackensack
Zip:
07601
Country:
United States
Status:
Recruiting
Facility:
Name:
Vassar Brothers Medical Center
Address:
City:
Poughkeepsie
Zip:
12601
Country:
United States
Status:
Recruiting
Facility:
Name:
SUNY Upstate Medical University
Address:
City:
Syracuse
Zip:
13210
Country:
United States
Status:
Recruiting
Facility:
Name:
Memorial Hermann Cancer Center
Address:
City:
Houston
Zip:
77030
Country:
United States
Status:
Recruiting
Facility:
Name:
Baylor Scott & White Medical Center - Round Rock
Address:
City:
Round Rock
Zip:
78665
Country:
United States
Status:
Recruiting
Facility:
Name:
Bon Secours Memorial Regional Medical Center
Address:
City:
Mechanicsville
Zip:
23116
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Bon Secours St. Francis Medical Center
Address:
City:
Midlothian
Zip:
23114
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Bon Secours at St. Mary's Hospital
Address:
City:
Richmond
Zip:
23226
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Swedish Cancer Institute
Address:
City:
Seattle
Zip:
98104
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Swedish Medical Center
Address:
City:
Seattle
Zip:
98122
Country:
United States
Status:
Not yet recruiting
Facility:
Name:
Aurora Health Center - Southern Lakes
Address:
City:
Burlington
Zip:
52105
Country:
United States
Status:
Recruiting
Facility:
Name:
Aurora Medical Centers - Grafton
Address:
City:
Grafton
Zip:
53024-9201
Country:
United States
Status:
Recruiting
Facility:
Name:
Aurora BayCare Medical Center
Address:
City:
Green Bay
Zip:
54311
Country:
United States
Status:
Recruiting
Facility:
Name:
Aurora Health Center - Kenosha
Address:
City:
Kenosha
Zip:
53142
Country:
United States
Status:
Recruiting
Facility:
Name:
Aurora Health Center Milwaukee - Good Hope
Address:
City:
Milwaukee
Zip:
53209
Country:
United States
Status:
Recruiting
Facility:
Name:
Aurora St Luke's Medical Center
Address:
City:
Milwaukee
Zip:
53215
Country:
United States
Status:
Recruiting
Facility:
Name:
Aurora Medical Center - Summit
Address:
City:
Summit
Zip:
53066
Country:
United States
Status:
Recruiting
Facility:
Name:
Aurora Cancer CAre
Address:
City:
Wauwatosa
Zip:
53226
Country:
United States
Status:
Recruiting
Facility:
Name:
CIPREC
Address:
City:
Ciudad Autonoma de Buenos Aires
Zip:
C1119ACN
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Centro de Investigaciones Metabólicas (CINME)
Address:
City:
Ciudad Autónoma De Buenos Aires, Ciudad Autónoma D
Zip:
C1027AAP
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Fundación Cenit Para La Investigación En Neurociencias
Address:
City:
Caba
Zip:
1125
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Organizacion Medica de Investigacion
Address:
City:
Caba
Zip:
C1015ABO
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Hospital Británico de Buenos Aires
Address:
City:
Caba
Zip:
CP1280AEB
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Clinica Viedma S. A
Address:
City:
Viedma
Zip:
R8500ACE
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Instituto de Oncología de Rosario
Address:
City:
Rosario
Zip:
S2000KZE
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Sanatorio de La Mujer
Address:
City:
Rosario
Zip:
S2000ORE
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Centro Para la Atención Integral del Paciente Oncologico (CAIPO)
Address:
City:
San Miguel de Tucuman
Zip:
4000
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Exelsus - Oncología Clínica
Address:
City:
San Miguel de Tucumán
Zip:
4000
Country:
Argentina
Status:
Not yet recruiting
Facility:
Name:
Fundación Respirar
Address:
City:
Ciudad Autónoma Buenos Aires
Zip:
C1426ABP
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Centro Medico Austral
Address:
City:
Ciudad Autónoma de Buenos Aires
Zip:
1019
Country:
Argentina
Status:
Not yet recruiting
Facility:
Name:
Clínica Universitaria Reina Fabiola
Address:
City:
Córdoba
Zip:
X5004FHP
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Fundación CORI para la Investigación y Prevención del Cáncer
Address:
City:
La Rioja
Zip:
F5300COE
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Sanatorio Norte
Address:
City:
Santiago del Estero
Zip:
4200
Country:
Argentina
Status:
Recruiting
Facility:
Name:
Macquarie University
Address:
City:
North Ryde
Zip:
2109
Country:
Australia
Status:
Not yet recruiting
Facility:
Name:
Icon Cancer Centre Townsville
Address:
City:
Rosslea
Zip:
4812
Country:
Australia
Status:
Recruiting
Facility:
Name:
Icon Cancer Centre Townsville
Address:
City:
Townsville
Zip:
4812
Country:
Australia
Status:
Recruiting
Facility:
Name:
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
Address:
City:
Salvador
Zip:
41253-190
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Crio - Centro Regional Integrado de Oncologia
Address:
City:
Fortaleza
Zip:
60336232
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Pernambuco
Address:
City:
Recife
Zip:
50070-480
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Liga Norte Riograndense Contra o Câncer
Address:
City:
Natal
Zip:
59062-000
Country:
Brazil
Status:
Recruiting
Facility:
Name:
ONCOSITE - Centro de Pesquisa Clinica em Oncologia
Address:
City:
Ijui
Zip:
98700-000
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Irmandade da Santa Casa de Misericórdia de Porto Alegre
Address:
City:
Porto Alegre
Zip:
90020-090
Country:
Brazil
Status:
Recruiting
Facility:
Name:
Irmandade da Santa Casa de Misericórdia de Porto Alegre
Address:
City:
Porto Alegre
Zip:
90050-170
Country:
Brazil
Status:
Recruiting
Facility:
Name:
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
Address:
City:
Porto Alegre
Zip:
90110-270
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Hospital São Lucas da PUCRS
Address:
City:
Porto Alegre
Zip:
90610-000
Country:
Brazil
Status:
Recruiting
Facility:
Name:
Centro de Pesquisa Clínica - Área Administrativa
Address:
City:
Porto Alegre
Zip:
90850-170
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Hospital Mae de Deus
Address:
City:
Porto Alegre
Zip:
90880-480
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Fundação Pio XII - Hospital de Câncer de Barretos
Address:
City:
Barretos
Zip:
14784400
Country:
Brazil
Status:
Recruiting
Facility:
Name:
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul
Address:
City:
São Caetano do Sul
Zip:
09541-270
Country:
Brazil
Status:
Recruiting
Facility:
Name:
Fundação Faculdade Regional de Medicina de São José do Rio Preto
Address:
City:
São José do Rio Preto
Zip:
15090000
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Hospital de Base de São José do Rio Preto
Address:
City:
São José do Rio Preto
Zip:
15091-000
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Hospital Esperança Recife: Pronto Atendimento 24h
Address:
City:
Pernambuco
Zip:
50070-480
Country:
Brazil
Status:
Not yet recruiting
Facility:
Name:
Dr. Everett Chalmers Regional Hospital
Address:
City:
Fredericton
Zip:
E3B 5N5
Country:
Canada
Status:
Recruiting
Facility:
Name:
Cape Breton Regional Hospital
Address:
City:
Sydney
Zip:
B1P 1P3
Country:
Canada
Status:
Recruiting
Facility:
Name:
Royal Victoria Regional Health Centre
Address:
City:
Barrie
Zip:
L4M 6M2
Country:
Canada
Status:
Recruiting
Facility:
Name:
William Osler Health System
Address:
City:
Brampton
Zip:
L6R 3J7
Country:
Canada
Status:
Recruiting
Facility:
Name:
Oakville Trafalgar Memorial Hospital
Address:
City:
Oakville
Zip:
L6M 0L8
Country:
Canada
Status:
Recruiting
Facility:
Name:
CIUSSS- saguenay-Lac-Saint-Jean
Address:
City:
Chicoutimi
Zip:
G7H 5H6
Country:
Canada
Status:
Recruiting
Facility:
Name:
Jewish General Hospital
Address:
City:
Montreal
Zip:
H3T 1E2
Country:
Canada
Status:
Recruiting
Facility:
Name:
Iceg Clinic
Address:
City:
La Florida
Zip:
8241470
Country:
Chile
Status:
Not yet recruiting
Facility:
Name:
Cancer Hospital Chinese Academy of Medical Science
Address:
City:
Beijing
Zip:
100021
Country:
China
Status:
Recruiting
Facility:
Name:
Peking University People's Hospital
Address:
City:
Beijing
Zip:
100044
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Beijing Cancer hospital
Address:
City:
Beijing
Zip:
100142
Country:
China
Status:
Recruiting
Facility:
Name:
Chongqing University Cancer Hospital
Address:
City:
Chongqing
Zip:
400030
Country:
China
Status:
Not yet recruiting
Facility:
Name:
The First People's Hospital of Foshan
Address:
City:
Foshan
Zip:
528041
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Guangdong Provincial People's Hospital
Address:
City:
Guangzhou
Zip:
510000
Country:
China
Status:
Recruiting
Facility:
Name:
Sun Yat-sen University Cancer Center
Address:
City:
Guangzhou
Zip:
510060
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Guangdong Provincial People's Hospital
Address:
City:
Guangzhou
Zip:
510080
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Guangxi Medical University Affiliated Tumor Hospital
Address:
City:
Nanning
Zip:
530021
Country:
China
Status:
Recruiting
Facility:
Name:
Harbin Medical University Cancer Hospital
Address:
City:
Harbin
Zip:
150081
Country:
China
Status:
Not yet recruiting
Facility:
Name:
The First Affiliated Hospital of Henan University of Science &Technology
Address:
City:
Luoyang
Zip:
471003
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Henan Cancer Hospital
Address:
City:
Zhengzhou
Zip:
450008
Country:
China
Status:
Recruiting
Facility:
Name:
Tongji Hospital Tongji Medical,Science & Technology
Address:
City:
Wuhan
Zip:
430030
Country:
China
Status:
Recruiting
Facility:
Name:
Hubei Cancer Hospital
Address:
City:
Wuhan
Zip:
430079
Country:
China
Status:
Recruiting
Facility:
Name:
Hunan Cancer Hospital
Address:
City:
Changsha
Zip:
410013
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Hunan Cancer Hospital
Address:
City:
Changsha
Zip:
410013
Country:
China
Status:
Recruiting
Facility:
Name:
Jiangsu Province Hospital
Address:
City:
Nanjing
Zip:
210029
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Jilin Province Tumor Hospital
Address:
City:
Changchun
Zip:
130000
Country:
China
Status:
Not yet recruiting
Facility:
Name:
The First Hospital of Jilin University
Address:
City:
Changchun
Zip:
130021
Country:
China
Status:
Not yet recruiting
Facility:
Name:
The First Hospital of China Medical University
Address:
City:
Shenyang
Zip:
110000
Country:
China
Status:
Recruiting
Facility:
Name:
The First Affiliated Hospital of Xi'an Jiaotong University
Address:
City:
Xi'an
Zip:
710061
Country:
China
Status:
Recruiting
Facility:
Name:
Fudan University Shanghai Cancer Center
Address:
City:
Shanghai
Zip:
200032
Country:
China
Status:
Recruiting
Facility:
Name:
West China Hospital of Sichuan University
Address:
City:
Chengdu
Zip:
610041
Country:
China
Status:
Recruiting
Facility:
Name:
Tianjin Medical University Cancer Institute & Hospital
Address:
City:
Tianjing
Zip:
300060
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Address:
City:
Hangzhou
Zip:
310016
Country:
China
Status:
Recruiting
Facility:
Name:
Zhejiang Cancer Hospital
Address:
City:
Hangzhou
Zip:
310022
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Zhejiang Cancer Hospital
Address:
City:
Hangzhou
Zip:
310022
Country:
China
Status:
Recruiting
Facility:
Name:
Taizhou Hospital of Zhejiang Province
Address:
City:
Linhai
Zip:
317000
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Taizhou Hospital of Zhejiang Province
Address:
City:
Taizhou
Zip:
317000
Country:
China
Status:
Not yet recruiting
Facility:
Name:
The First Affiliated Hospital of Wenzhou Medical University
Address:
City:
Wenzhou
Zip:
32500
Country:
China
Status:
Not yet recruiting
Facility:
Name:
Rajiv Gandhi Cancer Institute And Research Centre
Address:
City:
New Delhi
Zip:
110085
Country:
India
Status:
Recruiting
Facility:
Name:
Kiran Hospital - Multi Super Speciality Hospital and Research Center
Address:
City:
Surat
Zip:
395004
Country:
India
Status:
Recruiting
Facility:
Name:
Spandana Oncology Centre (SOC)
Address:
City:
Bangalore
Zip:
560069
Country:
India
Status:
Recruiting
Facility:
Name:
Tata Memorial Hospital
Address:
City:
Mumbai
Zip:
400012
Country:
India
Status:
Recruiting
Facility:
Name:
Kims Kingsway Hospital
Address:
City:
Nagpur
Zip:
440001
Country:
India
Status:
Recruiting
Facility:
Name:
Apex Wellness Hospital
Address:
City:
Nashik
Zip:
422009
Country:
India
Status:
Recruiting
Facility:
Name:
Sahyadri Super Speciality Hospital
Address:
City:
Pune
Zip:
411004
Country:
India
Status:
Recruiting
Facility:
Name:
Bhakti Vedanta Hospital and Research Institute
Address:
City:
Thane
Zip:
401107
Country:
India
Status:
Recruiting
Facility:
Name:
GBH Memorial cancer Hospital and American International Institute of Medical sciences
Address:
City:
Udaipur
Zip:
313002
Country:
India
Status:
Recruiting
Facility:
Name:
Apollo Multispeciality Hospitals limited
Address:
City:
Kolkata
Zip:
700054
Country:
India
Status:
Not yet recruiting
Facility:
Name:
Soroka Medical Center
Address:
City:
Be'er Sheva
Zip:
8400000
Country:
Israel
Status:
Not yet recruiting
Facility:
Name:
Rabin Medical Center
Address:
City:
Petah Tikva
Zip:
4941492
Country:
Israel
Status:
Recruiting
Facility:
Name:
Rambam Health Care Campus
Address:
City:
Haifa
Zip:
3109601
Country:
Israel
Status:
Recruiting
Facility:
Name:
Shaare Zedek Medical Center
Address:
City:
Jerusalem
Zip:
9103102
Country:
Israel
Status:
Recruiting
Facility:
Name:
Aichi Cancer Center Hospital
Address:
City:
Nagoya
Zip:
464-8681
Country:
Japan
Status:
Recruiting
Facility:
Name:
Nagoya University Hospital
Address:
City:
Nagoya
Zip:
466-8560
Country:
Japan
Status:
Recruiting
Facility:
Name:
Nagoya City University Hospital
Address:
City:
Nagoya
Zip:
467-8602
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Chiba cancer center
Address:
City:
Chiba-shi
Zip:
260-8717
Country:
Japan
Status:
Recruiting
Facility:
Name:
National Hospital Organization Shikoku Cancer Center
Address:
City:
Matsuyama
Zip:
791-0280
Country:
Japan
Status:
Recruiting
Facility:
Name:
Gunma Prefectural Cancer Center
Address:
City:
Otashi
Zip:
373-8550
Country:
Japan
Status:
Recruiting
Facility:
Name:
National Hospital Organization Hokkaido Cancer Center
Address:
City:
Sapporo
Zip:
003-0804
Country:
Japan
Status:
Recruiting
Facility:
Name:
Tohoku University Hospital
Address:
City:
Sendai
Zip:
980-8574
Country:
Japan
Status:
Recruiting
Facility:
Name:
Osaka International Cancer Institute
Address:
City:
Osaka-shi
Zip:
541-8567
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Osaka University Hospital
Address:
City:
Suita
Zip:
565-0871
Country:
Japan
Status:
Recruiting
Facility:
Name:
Saitama Medical University International Medical Center
Address:
City:
Hidaka
Zip:
350-1298
Country:
Japan
Status:
Recruiting
Facility:
Name:
St. Luke's International Hospital
Address:
City:
Chuo-ku
Zip:
104-8560
Country:
Japan
Status:
Recruiting
Facility:
Name:
The Cancer Institute Hospital of JFCR
Address:
City:
Koto
Zip:
135-8550
Country:
Japan
Status:
Recruiting
Facility:
Name:
Center Hospital of the National Center for Global Health and Medicine
Address:
City:
Shinjuku-ku
Zip:
162-8655
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Center Hospital of the National Center for Global Health and Medicine
Address:
City:
Shinjyuku-ku
Zip:
162-8655
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Hiroshima City Hiroshima Citizens Hospital
Address:
City:
Hiroshima
Zip:
730-8518
Country:
Japan
Status:
Recruiting
Facility:
Name:
Kumamoto Shinto General Hospital
Address:
City:
Kumamoto
Zip:
862-8655
Country:
Japan
Status:
Not yet recruiting
Facility:
Name:
Okayama University Hospital
Address:
City:
Okayama
Zip:
700-8558
Country:
Japan
Status:
Recruiting
Facility:
Name:
National Hospital Organization Osaka National Hospital
Address:
City:
Osaka
Zip:
540-0006
Country:
Japan
Status:
Recruiting
Facility:
Name:
Inha University Hospital
Address:
City:
Incheon
Zip:
22332
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
National Cancer Center
Address:
City:
Goyang-si
Zip:
10408
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
CHA Bundang Medical Center, CHA University
Address:
City:
Seongnam-si
Zip:
13496
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Seoul National University Bundang Hospital
Address:
City:
Seongnam
Zip:
13620
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Ajou University Hospital
Address:
City:
Suwon-si
Zip:
16499
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Pusan National University Hospital
Address:
City:
Busan
Zip:
49241
Country:
Korea, Republic of
Status:
Active, not recruiting
Facility:
Name:
Seoul National University Hospital
Address:
City:
Seoul
Zip:
03080
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Kangbuk Samsung Hospital
Address:
City:
Seoul
Zip:
03181
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Severance Hospital, Yonsei University Health System
Address:
City:
Seoul
Zip:
03722
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Asan Medical Center
Address:
City:
Seoul
Zip:
05505
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Gangnam Severance Hospital, Yonsei University Health System
Address:
City:
Seoul
Zip:
06273
Country:
Korea, Republic of
Status:
Not yet recruiting
Facility:
Name:
Gangnam Severance Hospital, Yonsei University Health System
Address:
City:
Seoul
Zip:
06273
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Samsung Medical Center
Address:
City:
Seoul
Zip:
06351
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Korea University Guro Hospital
Address:
City:
Seoul
Zip:
08308
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Ewha Womans University Mokdong Hospital
Address:
City:
Seoul
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Keimyung University Dongsan Hospital
Address:
City:
Daegu
Zip:
42601
Country:
Korea, Republic of
Status:
Recruiting
Facility:
Name:
Cryptex Investigación Clínica S.A. de C.V.
Address:
City:
Cuauhtémoc, Ciudad De México
Zip:
06100
Country:
Mexico
Status:
Recruiting
Facility:
Name:
Mexico Centre for Clinical Research S.A de C.V
Address:
City:
Mexico City
Zip:
03100
Country:
Mexico
Status:
Recruiting
Facility:
Name:
COI Centro Oncologico Internacional S.A.P.I. de C.V.
Address:
City:
Mexico City
Zip:
04700
Country:
Mexico
Status:
Recruiting
Facility:
Name:
Boca Clinical Trials Mexico S.C.
Address:
City:
Guadajalara
Zip:
44600
Country:
Mexico
Status:
Recruiting
Facility:
Name:
Filios Alta Medicina S.A. de C.V.
Address:
City:
Monterrey
Zip:
64460
Country:
Mexico
Status:
Recruiting
Facility:
Name:
Unidad de Investigación en Salud de Chihuahua, S.C.
Address:
City:
Chihuahua
Zip:
31203
Country:
Mexico
Status:
Recruiting
Facility:
Name:
Oaxaca Site Management Organization S.C.
Address:
City:
Oaxaca
Zip:
68000
Country:
Mexico
Status:
Recruiting
Facility:
Name:
Instituto Veracruzano en Investigación Clínica S.C.
Address:
City:
Veracruz
Zip:
91851
Country:
Mexico
Status:
Recruiting
Facility:
Name:
Tumor Zentrum Aarau
Address:
City:
Aarau
Zip:
5000
Country:
Switzerland
Status:
Recruiting
Facility:
Name:
Kantonsspital Olten
Address:
City:
Olten
Zip:
4600
Country:
Switzerland
Status:
Not yet recruiting
Facility:
Name:
China Medical University Hospital
Address:
City:
Taichung
Zip:
40447
Country:
Taiwan
Status:
Not yet recruiting
Facility:
Name:
National Cheng Kung University Hospital
Address:
City:
Tainan
Zip:
704
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
National Taiwan University Hospital
Address:
City:
Taipei
Zip:
10002
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Mackay Memorial Hospital
Address:
City:
Taipei
Zip:
10449
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Taipei Veterans General Hospital
Address:
City:
Taipei
Zip:
11217
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Koo Foundation Sun Yat-Sen Cancer Center
Address:
City:
Taipei
Zip:
112
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Chang Gung Medical Foundation-Linkou Branch
Address:
City:
Taoyuan
Zip:
333
Country:
Taiwan
Status:
Recruiting
Facility:
Name:
Medipol Mega Universite Hastanesi
Address:
City:
Stanbul
Zip:
34214
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Acibadem Altunizade Hospital
Address:
City:
Üsküdar / Stanbul
Country:
Turkey
Status:
Not yet recruiting
Facility:
Name:
Ege Universitesi Hastanesi
Address:
City:
Izmir
Zip:
35100
Country:
Turkey
Status:
Not yet recruiting
Facility:
Name:
Gulhane Egitim Arastirma Hastanesi
Address:
City:
Ankara
Zip:
06010
Country:
Turkey
Status:
Not yet recruiting
Facility:
Name:
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi
Address:
City:
Ankara
Zip:
06200
Country:
Turkey
Status:
Not yet recruiting
Facility:
Name:
Hacettepe Universite Hastaneleri
Address:
City:
Ankara
Zip:
06230
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Memorial Ankara Hastanesi
Address:
City:
Ankara
Zip:
06520
Country:
Turkey
Status:
Not yet recruiting
Facility:
Name:
Ultramar Medical Imaging Center
Address:
City:
Ankara
Zip:
06530
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Ankara Bilkent Şehir Hastanesi
Address:
City:
Ankara
Zip:
06800
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Ultramar Medical Imaging Center
Address:
City:
Ankara
Country:
Turkey
Status:
Not yet recruiting
Facility:
Name:
Dicle Üniversitesi
Address:
City:
Diyarbakir
Zip:
21200
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Erciyes Universitesi Tıp Fakultesi Hastaneleri
Address:
City:
Kayseri
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Kocaeli Üniversitesi
Address:
City:
Kocaeli
Zip:
41380
Country:
Turkey
Status:
Not yet recruiting
Facility:
Name:
Necmettin Erbakan Meram Medical Fac.
Address:
City:
Konya
Zip:
42080
Country:
Turkey
Status:
Recruiting
Facility:
Name:
Samsun Medical Park Hastanesi
Address:
City:
Samsun
Zip:
55200
Country:
Turkey
Status:
Recruiting
Facility:
Name:
The Princess Alexandra Hospital NHS Trust
Address:
City:
Harlow
Zip:
CM20 1QX
Country:
United Kingdom
Status:
Not yet recruiting
Facility:
Name:
The Royal Cornwall Hospital
Address:
City:
Truro
Zip:
TR1 3LJ
Country:
United Kingdom
Status:
Not yet recruiting
Facility:
Name:
Imperial College Healthcare NHS Trust, Charing Cross Hospital
Address:
City:
London
Zip:
W6 8RF
Country:
United Kingdom
Status:
Recruiting
Facility:
Name:
Sarah Cannon Research Institute UK
Address:
City:
London
Zip:
w1g 6ad
Country:
United Kingdom
Status:
Recruiting
Facility:
Name:
Western General Hospital
Address:
City:
Edinburgh
Zip:
EH4 2XU
Country:
United Kingdom
Status:
Not yet recruiting
Facility:
Name:
University Hospital Coventry & Warwickshire
Address:
City:
Coventry
Zip:
CV2 2DX
Country:
United Kingdom
Status:
Not yet recruiting
Facility:
Name:
The Royal Surrey County Hospital
Address:
City:
Guildford
Zip:
GU2 7XX
Country:
United Kingdom
Status:
Not yet recruiting
Facility:
Name:
The Christie NHS Foundation Trust
Address:
City:
Manchester
Zip:
M20 4GJ
Country:
United Kingdom
Status:
Recruiting
Facility:
Name:
Great Western Hospital
Address:
City:
Swindon
Zip:
SN3 6BB
Country:
United Kingdom
Status:
Not yet recruiting
Start date:
January 9, 2024
Completion date:
December 8, 2028
Lead sponsor:
Agency:
Pfizer
Agency class:
Industry
Source:
Pfizer
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06105632
https://pmiform.com/clinical-trial-info-request?StudyID=C4391022
