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Trial Title:
Systems Oncology Approach to Optimize Ovarian Cancer Treatment
NCT ID:
NCT06117384
Condition:
Ovarian Cancer
Conditions: Official terms:
Ovarian Neoplasms
Carcinoma, Ovarian Epithelial
Study type:
Observational [Patient Registry]
Overall status:
Recruiting
Study design:
Time perspective:
Prospective
Intervention:
Intervention type:
Genetic
Intervention name:
Biomolecular profiling
Description:
Molecular and functional analysis of biospecimens, including tumor-normal Whole-exome
sequencing, bulk and single-cell RNAsequencing, spatial proteomics, functional testing.
Summary:
The overall aim is to identify effective therapeutic strategies to ovarian cancer (OC)
using serial tumor, ascites and blood samples, and carry out state-of-the-art sequencing
approaches, functional assays and associated bioinformatics to understand mechanisms
behind chemoresistance in OC and identify new treatment options for OC patients. In this
observational trial, we will systematically collect, analyze and interpret functional,
molecular and clinical data from real-world ovarian cancer patients.
Criteria for eligibility:
Study pop:
All ovarian cancer patients who give their informed consent to the study.
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Patients diagnosed with ovarian cancer
- Available tumor tissue/blood samples
Exclusion Criteria:
- Inability to consent to the study
Gender:
Female
Minimum age:
N/A
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Helsinki University and Helsinki University Hospital
Address:
City:
Helsinki
Zip:
00014
Country:
Finland
Status:
Recruiting
Contact:
Last name:
Anniina Färkkilä, MD PhD
Phone:
+358504272060
Email:
anniina.farkkila@helsinki.fi
Start date:
January 1, 2022
Completion date:
December 31, 2027
Lead sponsor:
Agency:
University of Helsinki
Agency class:
Other
Collaborator:
Agency:
Helsinki University Central Hospital
Agency class:
Other
Source:
University of Helsinki
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06117384
