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Trial Title:
Most Total Pancreatectomies for Ductal Adenocarcinoma Can Be Replaced by Whipple Over the Splenic Artery: A Before and After Study
NCT ID:
NCT06119776
Condition:
Ductal Adenocarcinoma of the Pancreas
Conditions: Official terms:
Adenocarcinoma
Conditions: Keywords:
Ductal Adenocarcinoma
Pancreatectomies
Whipple
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Prospective
Intervention:
Intervention type:
Procedure
Intervention name:
Whipple over the splenic artery
Description:
Treatment for pancreatic ductal cell adenocarcinoma
Arm group label:
Study
Intervention type:
Procedure
Intervention name:
Total pancreatectomy
Description:
Treatment for pancreatic ductal cell adenocarcinoma
Arm group label:
Control
Summary:
Recently, more and more total pancreatectomy (TP) has been performed for pancreatic
ductal cell adenocarcinoma (PDCA) which abuts or involves both gastroduodenal and splenic
arteries. Warshaw's procedure (spleen-preserving distal pancreatectomy with excision of
splenic vessels) has been safely performed for years. Likewise, both pancreatic tail and
spleen can be preserved after excision of splenic vessels for leftward extension of
pancreatic parenchyma transaction line during Whipple (WOTSA). In that case, TP can be
replaced by WOTSA. This uncontrolled before and after study assesses the safety and
efficacy of a new technique "Whipple over the splenic artery (WOTSA)" as a treatment for
PDAC which traditionally requires total pancreatectomy (TP).
Detailed description:
Recently, more and more total pancreatectomy (TP) has been performed for pancreatic
ductal cell adenocarcinoma (PDCA) which abuts or involves both gastroduodenal and splenic
arteries. Warshaw's procedure (spleen-preserving distal pancreatectomy with excision of
splenic vessels) has been safely performed for years. Likewise, both pancreatic tail and
spleen can be preserved after excision of splenic vessels for leftward extension of
pancreatic parenchyma transaction line during Whipple (WOTSA). In that case, TP can be
replaced by WOTSA. This uncontrolled before and after study assesses the safety and
efficacy of a new technique "Whipple over the splenic artery (WOTSA)" as a treatment for
PDAC which traditionally requires total pancreatectomy (TP).
Methods: The study group comprised 40 consecutive patients who underwent WOTSA for PDAC.
Their clinicopathological characteristics and survival were compared with those of a
historical control group comprising 30 consecutive patients who underwent TP between.
Criteria for eligibility:
Study pop:
pancreatic ductal cell adenocarcinoma (PDCA) patients
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- pancreatic ductal cell adenocarcinoma (PDCA) patients
Exclusion Criteria:
- Patient undergoing palliative pancreatectomy, other malignancies with distant
metastases
- Vulnerable groups
Gender:
All
Minimum age:
20 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
National Taiwan University Hospital
Address:
City:
Taipei
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Ting-Chung Kuo
Phone:
+88623123456
Phone ext:
62557
Email:
tinakuo1204@gmail.com
Start date:
May 20, 2020
Completion date:
May 20, 2025
Lead sponsor:
Agency:
National Taiwan University Hospital
Agency class:
Other
Source:
National Taiwan University Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06119776
