A Study of Simmitinib Plus SG001 in Advanced Solid Tumors

Trial Title: A Study of Simmitinib Plus SG001 in Advanced Solid Tumors

NCT ID: NCT06132217

Condition: Advanced Solid Tumor

Conditions: Official terms:
Neoplasms

Study type: Interventional

Study phase: Phase 1/Phase 2

Overall status: Not yet recruiting

Study design:

Allocation: Non-Randomized

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Simmitinib
Description: Patients will oral administration according to study protocol until disease progression, death, unacceptable toxicity, loss of follow-up, withdrawal of consent or other conditions meet the end of treatment criteria.
Arm group label: Dose Escalation Phase Cohort 1
Arm group label: Dose Escalation Phase Cohort 2
Arm group label: Dose Escalation Phase Cohort 3
Arm group label: Dose Expansion Phase Cohort A
Arm group label: Dose Expansion Phase Cohort B
Arm group label: Dose Expansion Phase Cohort C

Intervention type: Drug
Intervention name: SG001
Description: Patients will receive intravenous infusion of SG001 according to study protocol until disease progression, unacceptable toxicity, meeting the suspension or termination criteria, or up to 24 months in patients without disease progression.
Arm group label: Dose Escalation Phase Cohort 1
Arm group label: Dose Escalation Phase Cohort 2
Arm group label: Dose Escalation Phase Cohort 3
Arm group label: Dose Expansion Phase Cohort A
Arm group label: Dose Expansion Phase Cohort B
Arm group label: Dose Expansion Phase Cohort C

Summary: This is an open-label Phase I/II trial of simmitinib plus SG001 in patients with advanced solid tumors. Phase I will determine and confirm the maximum tolerated dose (MTD) and recommended phase II dose (RP2D) for simmitinib in combination with SG001 in patients with advanced solid tumors. Phase 2 (Expansion) will evaluate the safety and efficacy of the combination in 3 cohorts at the RP2D from Phase I.

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. Have fully understood and voluntarily sign the ICF for this study; 2. Age of 18-75 years (inclusive); 3. Dose escalation phase: patients with histologically or cytologically confirmed inoperable or metastatic advanced solid tumors; 4. Dose expansion phase: patients who have failed standard treatment (PD or intolerable toxicity after treatment), have no available standard treatment.According to the previous data, the specific tumor cohort was expanded. 5. In the expansion phase, patients should agree to provide tissue specimens for detection of PD-L1 expression levels and/or MSI or dMMR status; 6. At least one measurable lesion according to RECIST 1.1; 7. Eastern Cooperative Oncology Group (ECOG) performance status (PS) score 0-1; 8. Adequate organ function, defined as: Neutrophil count (ANC) ≥ 1.5 × 10^9/L; Platelet count (PLT) ≥ 100× 10^9/L; Hemoglobin (Hb) ≥ 90 g/L; Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × upper limit of normal (ULN) (≤ 5.0 × ULN for patients with liver metastases); Serum total bilirubin (TBIL) ≤ 1.5 × ULN; Serum creatinine ≤ 1.5 × ULN; Prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio(INR)≤1.5 × ULN; Thyroid Stimulating Hormone (TSH)≤ULN; Left ventricular ejection fraction (LVEF)≥50%; Male and female patients of childbearing age must agree to take effective contraceptive measures during treatment and within 6 months after the last dose of treatment. Exclusion Criteria: 1. Patients who have previously received any anti-tumor therapy within 4 weeks prior to the first dose; 2. Urine protein ≥ ++ and 24 h urine protein > 1.0g at screening period; 3. Symptomatic central nervous system (CNS) metastases or meningeal metastases; 4. Patients who have previously received any live attenuated vaccine within 4 weeks before the first use of the study treatment or are expected to received any live attenuated vaccine during the study; 5. History of allergic reactions attributed to any monoclonal antibody, and uncontrolled history of allergic asthma; 6. Patients with other types of malignant tumors within 5 years prior to the screening, except for radically resected, non-recurrent skin basal cell carcinoma, skin squamous cell carcinoma, superficial bladder cancer, cervical cancer in situ, or other carcinoma in situ; 7. Patients with any active autoimmune disease requiring systemic therapy within 2 years prior to the first dose; 8. Patients with bleeding tendency; active bleeding or a history of heavy bleeding within the past 6 months; 9. Presence of any severe and/or uncontrolled disease before starting treatment; 10. Any active infection requiring antibiotics or hormones systemic treatment by intravenous infusion within 14 days prior to the first dose; 11. Dose expansion phase: Prior systemic therapy with immunosuppressants or immunoagonists targeting PD-1, PD-L1, CTLA-4, etc; 12. Dose expansion phase: Prior systemic therapy with Antiangiogenic drugs including Anlotinib, Afatinib , Lenvatinib, Sorafenib and Fruquintinib, etc;

Gender: All

Minimum age: 18 Years

Maximum age: 75 Years

Healthy volunteers: No

Locations:

Facility:
Name: Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College

Address:
City: Beijing
Zip: 100000
Country: China

Contact:
Last name: Lingying Wu

Phone: 86-010-87798996
Email: wulingying@csco.org.cn

Start date: January 30, 2024

Completion date: January 30, 2027

Lead sponsor:
Agency: Shanghai Runshi Pharmaceutical Technology Co., Ltd
Agency class: Industry

Source: Shanghai Runshi Pharmaceutical Technology Co., Ltd

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06132217