WEST-KOaST Study: WES Analysis of Testicular Cancer Patientsand Their First-degree Family Members

Trial Title: WEST-KOaST Study: WES Analysis of Testicular Cancer Patientsand Their First-degree Family Members

NCT ID: NCT06142500

Condition: Testicular Cancer

Conditions: Official terms:
Testicular Neoplasms

Conditions: Keywords:
testicular cancer
cancer
familiarity
genetic
male infertility

Study type: Interventional

Study phase: N/A

Overall status: Not yet recruiting

Study design:

Allocation: Non-Randomized

Intervention model: Parallel Assignment

Primary purpose: Diagnostic

Masking: None (Open Label)

Intervention:

Intervention type: Genetic
Intervention name: Analysis of biological samples of saliva from testicular cancer patients and from their first-degree family members
Description: The project aims to collect biological samples of saliva from testicular cancer patients and from their first-degree family members; demographic-clinical variables will be also collected in order to draft a comprehensive panel of genes and gene modifications related to the testicular cancer, combining this survey with a very detailed descprition of this cohort of patient in terms of clinical features and quality of life
Arm group label: First-degree family members of patients with testicular cancer
Arm group label: Patients with testicular cancer

Summary: The project aims to identify the possible risk factors regarding the onset of the disease and to evaluate genes and gene modifications responsible for the onset od testicular cancer.

Detailed description: Testicular tumor represents a relatively rare disease that hit young-adults men. It represents 1% of all male cancers and 5% of all urological male tumors. Its incidence grow year by year. In the field of the oncological research, the lack of knowledge about genes related to this disease represent a very relevant clinical question. For this reason this project aims to collect biological samples of saliva from testicular cancer patients and from their first-degree family members; demographic-clinical variables will be also collected in order to draft a comprehensive panel of genes and gene modifications related to the testicular cancer, combining this survey with a very detailed description of this cohort of patient in terms of clinical features and quality of life.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Male testicular cancer patients with an age > 18 and < 90 - First degree family members of Male testicular cancer patients with an age > 18 and < 90 - Ability to read and sign the informed consent - Diagnosis of testicular cancer for the experimental group Exclusion Criteria: - Female for the experimental group - Second degree family members of Male testicular cancer patients - People with an age < 18 and > 90 - Diagnosis different from testicular cancer for the experimental group Incapacity to read and sign the informed consent

Gender: All

Minimum age: 18 Years

Maximum age: 90 Years

Healthy volunteers: Accepts Healthy Volunteers

Start date: December 1, 2023

Completion date: September 21, 2026

Lead sponsor:
Agency: IRCCS San Raffaele
Agency class: Other

Source: IRCCS San Raffaele

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06142500