Trial Title:
Examining Safety, Efficacy and Feasibility of Preoperative Propranolol in Patients With PDAC.
NCT ID:
NCT06145074
Condition:
Pancreatic Cancer
Surgery
Conditions: Official terms:
Pancreatic Neoplasms
Propranolol
Conditions: Keywords:
Propranolol
Beta-Blockers
PDAC
Pancreatic Cancer
Study type:
Interventional
Study phase:
Phase 2
Overall status:
Recruiting
Study design:
Allocation:
Randomized
Intervention model:
Parallel Assignment
Primary purpose:
Treatment
Masking:
Triple (Participant, Care Provider, Investigator)
Intervention:
Intervention type:
Drug
Intervention name:
Propranolol
Description:
Oral administration.
Arm group label:
Propranolol
Other name:
Inderal
Other name:
Propal
Intervention type:
Drug
Intervention name:
Placebo
Description:
Oral administration.
Arm group label:
Placebo
Other name:
Inactive drug
Summary:
The IMPULS trial is a randomized, triple-blinded, placebo controlled, single center,
pilot trial examining the efficacy and safety of preoperative propranolol in patients
scheduled for pancreatic cancer surgery. The study is conducted as a type 1 hybrid
efficacy-implementation trial of 30 patients.
This study is designed to provide pilot data for a future larger perioperative study of
propranolol with the aim of improving outcomes for pancreatic cancer surgery.
In total, 30 participants will be allocated in a 1:1 ratio with 15 participants enrolled
in each trial arm (propranolol vs. placebo). Participants will be allocated to either 40
mg propranolol twice daily or placebo twice daily in 10 days prior to planned surgery.
Primary outcomes: Evaluating the efficacy of preoperative propranolol on anxiety and in
pro-tumorigenic changes (e.g., in the tumor tissue and in blood samples) in patients
undergoing surgery for pancreatic cancer. Furthermore, to obtain follow up data (e.g.,
90-day mortality, postoperative complications etc. on the patients receiving propranolol
versus placebo). Heart rate variability among the participants will also be examined.
Secondary: Examining the safety and tolerability of 40 mg preoperative propranolol twice
daily in patients undergoing surgery for pancreatic cancer.
Tertiary: Evaluating the feasibility and implementation of the trial (using the APEASE
framework). This will help identify barriers and enablers to a future larger study.
Short-time propranolol treatment is considered safe with a mild and manageable
safety-profile. Risk-management, mitigations and guidelines to ensure patient safety is
included in the protocol. Since this clinical trial is exploratory in nature, no
sample-size calculation is performed.
Detailed description:
The study will be conducted as a pilot study to test efficacy, safety and feasibility of
propranolol on preoperative anxiety in patients undergoing abdominal surgery for
suspected pancreatic ductal adenocarcinoma (PDAC). Furthermore, the implementation of the
trial including compliance of the participants in a hybrid type 1 setup will be examined.
A total of 30 participants will be included and randomized to receive either propranolol
or placebo twice daily with 15 patients in each arm. Following this study, a power
calculation will be done to reveal the actual number of needed participants in each arm
for a potential follow-up randomized clinical trial on primary outcomes of interest.
Thus, the results from this study can be used for future power calculations for clinical
trials related to this topic.
Primary objectives: Efficacy
Evaluating the efficacy of preoperative propranolol on patient-experienced anxiety and on
tumorigenic gene expression compared to placebo is the primary objective of this trial.
Primary objectives are further divided in to primary clinical objectives, primary
translational objectives and exploratory endpoints.
Primary clinical objectives:
The primary clinical objectives are to evaluate preoperative patient-experienced anxiety
in patients receiving the nonselective beta-2-adrenergic receptor inhibitor, propranolol,
compared to placebo.
Further, heart rate variability (HRV) will be measured in order to evaluate changes in
the autonomous nervous system in relation to surgery. HRV is calculated from the interval
variation between consecutive R waves in an ECG time series and results suggest that it
is associated with the intra- and postoperative complications. As HRV reflects sinoatrial
node regulation, it is expected to be affected by the beta-adrenergic blockade caused by
preoperative propranolol. Analyzing this relation will provide essential knowledge in
understanding how HRV behaves perioperatively.
Lastly, follow up on the participants receiving propranolol compared to placebo will be
done.
Primary clinical effect parameters:
The following primary effect parameters will be used to investigate the primary clinical
objectives:
- Anxiety levels will primarily be measured by The Hamilton Anxiety Rating Scale
(HAM-A) and secondarily by The Hospital Anxiety and Depression Scale (HADS). The
European Organization for Research and Treatment of Cancer (EORTC) quality of life
questionnaire (QoL) for pancreatic cancer will be used to assess quality of life.
- HRV is calculated from continuous ECG gathered by a Holter monitor. The monitor is a
small wearable apparatus with one lead, placed on the patient's sternum. It is
applied on preoperative day 9 and will run continually until approximately
postoperative day 7. The actual calculations are achieved post hoc using software
specialized for HRV analysis.
- Follow up at 30- and 90-days after surgery including parameters such as survival and
postoperative complications.
- Long-term follow up at as 1-year, 3- year and 5-year following surgery including
survival and recurrence data.
Primary translational objectives:
The primary translational objectives are to examine the systemic (biochemical) and local
changes (TME of resections) to propranolol treatment compared to placebo. Alterations in
pro-metastatic and proinflammatory genes will specifically be analyzed.
Primary translational effect parameters:
- Blood sampling for the analysis of pro-metastatic and proinflammatory biomarkers.
- Expression of pro-metastatic and proinflammatory genes in formalin-fixed
paraffin-embedded (FFPE) cancer tissue obtained after surgical resection.
Exploratory endpoints:
The potential influence of inter-participant genetic variations (pharmacogenetics) on
measured levels of serum propranolol and response to surgical stress will be investigated
as exploratory endpoints. The differences in drug metabolism (pharmacokinetics) among
participants will also be of interest.
Secondary objectives: Safety
Secondarily, tolerance and safety of the intervention in this pilot study (e.g., adverse
effects, number of patients that need dose reduction etc.) will be evaluated. Changes in
heart rate (HR) and blood pressure (BP) during the intervention period will be examined
to test safety and tolerability of preoperative propranolol.
Secondary effect parameters:
- Measuring the changes in resting HR and BP during the intervention period with
handed out blood pressure monitors.
- Safety endpoints: light-headedness, lethargy, hypotension, bradycardia and other
symptoms and side-effects that may be related to propranolol treatment.
Tertiary objectives: Feasibility
Additionally, the feasibility of this intervention using the APEASE framework, which
assesses factors like affordability, practicability, effectiveness, acceptability,
side-effects, and equity, thereby determining the willingness to adopt this strategy will
be examined. This will help identify barriers and enablers to a future larger study. The
details regarding the APEASE framework are described under assessments.
This trial will be conducted in accordance with the principles of Good Clinical Practice
and reported according to the CONSORT and the complimentary StaRI standards for
implementation studies.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Patients with suspected surgically resectable pancreatic cancer
- Indication for surgical treatment with curative intend.
- Provide written informed consent.
- Patients minimum 18 years old.
Women of childbearing potential (WOCBP) are defined as women ranging from the period of
menarche till the post-menopausal period, unless permanently sterile (e.g., hysterectomy,
bilateral salpingectomy and bilateral oophorectomy). Post-menopause is defined as no
menses for 12 months without an alternative medical cause.
WOCBP should use a secure and highly effective birth control (as stated in the
"Recommendations related to contraception and pregnancy testing in clinical trials",
version 1.1., section 4.1, from the Clinical Trials Facilitation and Coordination Group)
during the entire period of the trial. In cases of uncertainty regarding pregnancy,
additional pregnancy testing either as highly sensitive serum or urine pregnancy test can
be used.
Exclusion Criteria:
- Patients with:
- Chronic hypotension, systolic blood pressure < 100 mg Hg for women and < 110 mg Hg
for men.
- Bradycardia, pulse < 50 beats per minute.
- Asthma or chronic obstructive lung disease
- Heart insufficiency with affected (< 50 %) left ventricle ejection fraction (LVEF),
treated or untreated.
- Kidney insufficiency, defined as eGFR < 20 ml/min.
- Liver insufficiency defined as chronically high liver enzymes or known chronic liver
disease (e.g., hepatitis, steatosis, cirrhosis).
- Cor pulmonale
- Cardiogenic shock
- Severe peripheral circulatory disorders
- Known or newly diagnosed current metabolic acidosis (e.g., in recent analysis of
arterial puncture).
- Known hypersensitivity to propranolol or to one or more of the excipients.
- Currently untreated pheochromocytoma.
- History of Prinzmetals angina.
- History of sick sinus syndrome or atrioventricular block.
- History of stroke or any previous cardiovascular event.
- History of neoadjuvant oncological treatment for suspected primary pancreatic
cancer.
- Recent or present (within 3 months) use of propranolol or any other beta-blocker.
- Recent or present (within 3 months) use of any of the following medications:
anxiolytics, calcium channel blockers, beta-adrenergic receptor agonist.
- Medical history that classifies the patient as frail or unsuitable for inclusion by
the examining physician.
- Histopathological examination revealing benign lesion.
- Predictable poor compliance, due to pre-existing psychiatric disease, dementia or
not able to read or speak sufficient Danish, resulting in not being able to provide
a well-informed written consent.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Department of Surgical Gastroenterology
Address:
City:
København
Zip:
2200
Country:
Denmark
Status:
Recruiting
Contact:
Last name:
Stefan K Burgdorf, MD, PhD
Phone:
+4535458225
Email:
stefan.kobbelgaard.burgdorf.02@regionh.dk
Facility:
Name:
Ismail Gögenur
Address:
City:
Køge
Zip:
4600
Country:
Denmark
Status:
Not yet recruiting
Contact:
Last name:
Ismail Gögenur, Prof.
Phone:
+4547323181
Email:
igo@regionsjaelland.dk
Contact backup:
Last name:
Adile Orhan, MD
Phone:
+4560807762
Email:
aor@regionsjaelland.dk
Investigator:
Last name:
Ismail Gögenur, Professor
Email:
Principal Investigator
Investigator:
Last name:
Adile Orhan, MD
Email:
Principal Investigator
Start date:
March 20, 2024
Completion date:
December 31, 2035
Lead sponsor:
Agency:
Zealand University Hospital
Agency class:
Other
Collaborator:
Agency:
Rigshospitalet, Denmark
Agency class:
Other
Source:
Zealand University Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06145074
https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=propranolol
