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Trial Title:
A Study of the Clinical Application of [18F]RCCB6 and [68Ga]Ga-NOTA-RCCB6 PET/CT Imaging in the Diagnosis of CD70-expressing Multiple Tumors
NCT ID:
NCT06148220
Condition:
Kidney Cancer
Lymphomas
Positron Emission Tomography
Conditions: Official terms:
Kidney Neoplasms
Study type:
Interventional
Study phase:
N/A
Overall status:
Recruiting
Study design:
Allocation:
Non-Randomized
Intervention model:
Single Group Assignment
Primary purpose:
Diagnostic
Masking:
None (Open Label)
Intervention:
Intervention type:
Radiation
Intervention name:
[18F]RCCB6 and [68Ga]Ga-NOTA-RCCB6 PET/CT imaging
Description:
Intravenous injection of 3.7 MBq [0.1 mCi]/kg of [18F]RCCB6 or [68Ga]Ga-NOTA-RCCB6 in a
single dose
Arm group label:
patients with lymphoma
Arm group label:
patients with renal cancer
Summary:
The aim of this study was to establish and optimize the [18F]RCCB6 and
[68Ga]Ga-NOTA-RCCB6 PET/CT imaging method, and its physiological and pathological
distribution characteristics, on the basis of which the diagnostic efficacy of the above
imaging agents in renal cancer (especially clear cell renal cell carcinoma) and lymphoma
was evaluated.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
1. Be between 18 and 65 years of age and of either sex.
2. Affected with renal cancer or lymphoma confirmed by puncture or surgical pathology.
3. Informed consent must be signed in writing by the subject or his/her legal guardian
or caregiver.
4. Willingness and ability to cooperate with all programs of this study.
Exclusion Criteria:
- Subjects meeting any of the following criteria will be excluded from the study:
1. Severe hepatic and renal insufficiency;
2. Targeted therapy prior to radiotherapy or PET/CT scan. Renal function: serum
creatinine less than or equal to the upper limit of the normal range;
3. Liver function: bilirubin, AST(SGOT)/ALT(SGPT) less than or equal to the upper
limit of the normal range.
4. History of serious surgery in the last month.
5. Those who have participated in other clinical trials during the same period.
Gender:
All
Minimum age:
18 Years
Maximum age:
65 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Huashan Hospital
Address:
City:
Shanghai
Zip:
200040
Country:
China
Status:
Recruiting
Contact:
Last name:
Yihui Guan, MD
Phone:
13764308300
Phone ext:
+86
Email:
guanyihui@hotmail.com
Start date:
October 1, 2023
Completion date:
September 1, 2024
Lead sponsor:
Agency:
Huashan Hospital
Agency class:
Other
Source:
Huashan Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06148220
