Trial Title:
The Relationships of Resistance Exercise, Walking, Myokine Secretion, Sarcopenia, Muscle Loss, Quality of Life, and Predictors in Cancer Patients Receiving Chemoradiotheray
NCT ID:
NCT06203301
Condition:
Cancer
Conditions: Official terms:
Sarcopenia
Study type:
Interventional
Study phase:
N/A
Overall status:
Recruiting
Study design:
Allocation:
Randomized
Intervention model:
Parallel Assignment
Primary purpose:
Prevention
Masking:
Double (Care Provider, Outcomes Assessor)
Intervention:
Intervention type:
Behavioral
Intervention name:
resistance exercise and walking
Description:
After receiving the cases, they were divided into 4 groups by random allocation:
1. Control group: No exercise intervention measures are performed, and the patients
carry out their daily lives according to their past living habits.
2. Resistance exercise group: Resistance exercise training begins before the patients
receive simultaneous radiochemotherapy, radiation therapy, or chemotherapy. The
patients are given resistance exercise training for 45 minutes each time, 3 times a
week, for 12 consecutive weeks. Afterwards, the patient is asked to regularly
perform resistance exercise on his own for at least 1 year.
3. Walking group: Walking training begins before the patients receive simultaneous
radiochemotherapy, radiation therapy, or chemotherapy. They should walk continuously
for 15 minutes at least twice a day and continue walking at least 5 days a week. Or
walk for at least 150 minutes a week and walk for at least 15 minutes continuously
each time for 12 consecutive weeks of walk
Arm group label:
resistance exercise and walking group
Arm group label:
resistance exercise group
Arm group label:
walking group
Summary:
Cancer is the first most common cause of death in Taiwan. The application of surgery and
chemoradiotherapy are used for treatment of patients with cancer. However, loss of muscle
mass, low muscle strength, low physical performance, and sarcopenia are induced during
chemoradiotherapy, consequently increased the risk of hematological toxicity and
nonhematological toxicity, decreased quality of life and survival rate. It was reported
that skeletal muscle can secretion of myokines, which contribute to muscle synthesis,
growth, repair, or atrophy. Investigators suggest that detection of blood concentration
of myokines and sarcopenia-related predictors can early detection potential individuals
who are susceptibility to sarcopenia in cervical cancer patients receiving
chemoradiotherapy. Also, resistance exercise was demonstrated to improve muscle mass,
muscle strength, physical performance, and sarcopenia. Investigators suggest that
resistance exercise can prevent cervical cancer patients from sarcopenia and improve
quality of life through regulation the concentration of myokines. However, there was no
study has been investigated their relationships. Therefore, investigators will conduct a
randomized controlled trial study to estimate (1) the effect of resistance exercise,
walking on regulation myokine secretion, improving skeletal muscle mass, muscle strength,
physical performance, sarcopenia, and quality of life in cancer receiving
chemoradiotherapy; (2) myokine level, muscle mass, muscle strength, physical performance,
and sarcopenia incidence in cancer patients before and after receiving chemoradiotherapy.
Detailed description:
Cancer is the first most common cause of death in Taiwan. The application of surgery and
chemoradiotherapy are used for treatment of patients with cancer. However, loss of muscle
mass, low muscle strength, low physical performance, and sarcopenia are induced during
chemoradiotherapy, consequently increased the risk of hematological toxicity and
nonhematological toxicity, decreased quality of life and survival rate. It was reported
that skeletal muscle can secretion of myokines, which contribute to muscle synthesis,
growth, repair, or atrophy. Investigators suggest that detection of blood concentration
of myokines and sarcopenia-related predictors can early detection potential individuals
who are susceptibility to sarcopenia in cervical cancer patients receiving
chemoradiotherapy. Also, resistance exercise was demonstrated to improve muscle mass,
muscle strength, physical performance, and sarcopenia. Investigators suggest that
resistance exercise can prevent cervical cancer patients from sarcopenia and improve
quality of life through regulation the concentration of myokines. However, there was no
study has been investigated their relationships. Therefore, investigators will conduct a
randomized controlled trial study to estimate (1) the effect of resistance exercise,
walking on regulation myokine secretion, improving skeletal muscle mass, muscle strength,
physical performance, sarcopenia, and quality of life in cancer receiving
chemoradiotherapy; (2) myokine level, muscle mass, muscle strength, physical performance,
and sarcopenia incidence in cancer patients before and after receiving chemoradiotherapy.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Cancer patients receiving chemoradiotherap
- age 20-70 years old
- participants who are available for doing resistance exercise and/or walking after
physical assessment by physician
- education level >=elementary school
Exclusion Criteria:
- Participants can't speak Mandarin, Taiwanese, or Hakka language.
Gender:
All
Minimum age:
20 Years
Maximum age:
70 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Taipei Medical University Hospital
Address:
City:
Taipei city
Zip:
110301
Country:
Taiwan
Status:
Recruiting
Contact:
Last name:
Hsiu Ting Tsai
Phone:
886-2-27361661
Phone ext:
6337
Email:
hsiuting@tmu.edu.tw;tsaihsiuting@yahoo.com.tw
Contact backup:
Last name:
Chai Hsuan Sun
Phone:
886+928894620
Email:
m432110019@tmu.edu.tw
Start date:
December 2, 2021
Completion date:
September 30, 2024
Lead sponsor:
Agency:
Taipei Medical University
Agency class:
Other
Source:
Taipei Medical University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06203301
