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Trial Title:
Study to Evaluate the Safety and Efficacy of Bicalutamide in Combination with Sunitinib in Patients with TKIs-resistant RCC
NCT ID:
NCT06222593
Condition:
Carcinoma, Renal Cell
Conditions: Official terms:
Carcinoma
Carcinoma, Renal Cell
Sunitinib
Bicalutamide
Study type:
Interventional
Study phase:
Phase 1/Phase 2
Overall status:
Not yet recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Intervention model description:
Longitudinal
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
Bicalutamide in combination with Sunitinib
Description:
Antineoplastics, Antiandrogen; CYP3A4 Inhibitor
Arm group label:
Bicalutamide in combination with Sunitinib
Other name:
(RS)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl sulfonyl]-2-hydroxy-2-methylpropanamide
Other name:
UNII: A0Z3NAU9DP
Other name:
CASODEX
Summary:
This is a Phase I/II open-label, efficacy and safety study of bicalutamide in combination
with sunitinib in patients with advanced renal cell carcinoma (RCC) who have been treated
with a receptor tyrosine kinase inhibitor (RTKI) and experienced disease progression.
Detailed description:
This is a Phase I/II open-label, efficacy and safety study of bicalutamide in combination
with sunitinib in patients with advanced renal cell carcinoma (RCC) who have been treated
with a receptor tyrosine kinase inhibitor (RTKI) and experienced disease progression.
After entering the study, patients will have sunitinib dosed at the 2 weeks ON and one
week OFF scheduled. Dose and schedule modification of sunitinib will be allowed at the
discretion of the treating physician. Bicalutamide will be administrated orally at 50 mg
daily. This clinical study will utilize the Simon's optimal two stage design.
Investigators will enroll 9 patients in the first stage. If no response is seen, then the
trial is terminated for futility. Otherwise, accrual continues to a total of 16 patients.
If at most 2 patients respond among the 16 patients, this therapy would warrant further
investigation.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
1. Be willing and able to provide written informed consent for the trial.
2. Be greater than or equal to 18 years of age on day of signing informed consent.
3. Have measurable disease based on RECIST 1.1
4. Have a performance status of 0-2 on the Eastern Cooperative Oncology Group (ECOG)
Performance Scale
5. Demonstrate adequate organ function
6. Female subject of childbearing potential should have a negative urine or serum
pregnancy test within 72 hours prior to receiving the first dose of study
medication.
7. Subjects of childbearing potential should be willing to use 2 methods of
contraception for the course of the study through 120 days after the last dose of
study medication
8. Male subjects without a previous vasectomy should agree to use an adequate method of
contraception (i.e. abstinence, condom with spermicidal foam/gel/film/cream)
starting with the first dose of study therapy through 120 days after the last dose
of study therapy.
9. Subjects have archival tumor tissue available or are willing to undergo a baseline
biopsy prior to treatment.
10. Subjects must have a life expectancy of at least 6 months.
Exclusion Criteria:
1. Is currently participating and receiving study therapy or has participated in a
study of an investigational agent and received study therapy or used an
investigational device within 4 weeks of the first dose of treatment.
2. Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any
other form of immunosuppressive therapy within 7 days prior to the first dose of
trial treatment.
3. Has active Bacillus tuberculosis (TB)
4. Has a known additional malignancy that is progressing or requires active treatment.
Exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of
the skin that has undergone potentially curative therapy or in situ cervical cancer.
5. Has known active central nervous system (CNS) metastases and/or carcinomatous
meningitis.
6. Has an active infection requiring systemic therapy.
7. Has a history or current evidence of any condition, therapy, or laboratory
abnormality that might confound the results of the trial, interfere with the
subject's participation for the full duration of the trial, or is not in the best
interest of the subject to participate, in the opinion of the treating investigator.
8. Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial.
9. Is pregnant or breastfeeding, or expecting to conceive or father children within the
projected duration of the trial, starting with the pre-screening or screening visit
through 120 days after the last dose of trial treatment.
10. Has a known history of Human Immunodeficiency Virus (HIV)
11. Has known active Hepatitis B or Hepatitis C
12. Has received a live vaccine within 30 days of planned start of study therapy
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Start date:
October 2024
Completion date:
July 1, 2026
Lead sponsor:
Agency:
State University of New York at Buffalo
Agency class:
Other
Source:
State University of New York at Buffalo
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06222593
