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Trial Title:
AI-Based Multimodal Multi-tasks Analysis Reveals Tumor Molecular Heterogeneity, Predicts Preoperative Lymph Node Metastasis and Prognosis in Papillary Thyroid Carcinoma
NCT ID:
NCT06241092
Condition:
Papillary Thyroid Carcinoma; Molecular Heterogeneity; Multi-model Analysis; Artificial Intelligence; Lymph Node Metastases; Disease-free Survival
Conditions: Official terms:
Carcinoma
Neoplasm Metastasis
Lymphatic Metastasis
Thyroid Neoplasms
Thyroid Cancer, Papillary
Thyroid Diseases
Study type:
Observational [Patient Registry]
Overall status:
Recruiting
Study design:
Time perspective:
Cross-Sectional
Summary:
This study involved a comprehensive analysis of 256 PTC patients from Sun Yat-sen
Memorial Hospital of Sun Yat-sen University (SYSMH) and 499 patients from The Cancer
Genome Atlas. DNA-based next-generation sequencing (NGS) and single-cell RNA sequencing
(scRNA-seq) were employed to capture genetic alterations and TME heterogeneity. A deep
learning multimodal model was developed by incorporating matched histopathology slide
images, genomic, transcriptomic, immune cells data to predict LNM and disease-free
survival (DFS).
Criteria for eligibility:
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
≥ 18 years of age Diagnosis of Papillary thyroid carcinoma at least one months before
trial Willing to return for required follow-up (posttest) visits
Exclusion Criteria:
The patient requires valve or other likely surgery The patient is unable to carry out any
physical activity without discomfort The patient had thyroid ache within three months
prior to enrollment The patient refuses to give informed consent The patient is a
candidate for coronary bypass surgery or something similar
Gender:
All
Minimum age:
N/A
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Address:
City:
Guangzhou
Zip:
510000
Country:
China
Status:
Recruiting
Contact:
Last name:
Herui Yao, PhD
Phone:
+8613500018020
Email:
yaoherui@mail.sysu.edu.cn
Contact backup:
Last name:
Yufang Yu
Phone:
+8613660238987
Email:
yuyf9@mail.sysu.edu.cn
Start date:
April 1, 2024
Completion date:
January 20, 2025
Lead sponsor:
Agency:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Agency class:
Other
Source:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06241092
