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Trial Title:
PET-guided Radiotherapy for Patients With Small Cell Lung Cancer.
NCT ID:
NCT06247163
Condition:
Small Cell Lung Carcinoma
Conditions: Official terms:
Small Cell Lung Carcinoma
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Prospective
Intervention:
Intervention type:
Radiation
Intervention name:
PET based Raditherapy boost
Description:
An Interim PET CT will be performed. If there is residual vital tumor, a higher radiation
dose will be applied.
Summary:
There is a prospective risk-adapted evaluation of the optimal dose of radiotherapy for
definitive radiotherapy of locally advanced small cell lung cancer within the corridor
recommended as standard therapy according to the current interdisciplinary S3 guideline
of the German Cancer Society/Cancer Aid/AWMF
Detailed description:
The main objective of this study is to determine whether patients with SCLC who have a
metabolically active residual tumor in the fluorodeoxyglucose (FDG) PET/CT scan after two
to three cycles of induction chemotherapy have a similarly low local recurrence rate with
higher dose. There is a prospective risk-adapted evaluation of the optimal dose of
radiotherapy for definitive radiotherapy of locally advanced small cell lung cancer
within the corridor recommended as standard therapy according to the current
interdisciplinary S3 guideline of the German Cancer Society/Cancer Aid/AWMF. Allocation
to PET boost, if confirmed vital tumor rest by PET CT and biopsy.
Criteria for eligibility:
Study pop:
Patients with confirmed diagnosis of small cell lung cancer
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
- Histopathologic confirmation
- Limited disease
Exclusion Criteria:
- Other histology than small cell lung cancer
- Further tumor diagnosis
- ECOG 3 or worse
- Extensive disease
- stage IV
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
University Hospital Essen
Address:
City:
Essen
Country:
Germany
Status:
Recruiting
Contact:
Last name:
Maja Guberina
Phone:
+4920127232321
Email:
maja.guberina@uk-essen.de
Start date:
February 22, 2024
Completion date:
June 22, 2029
Lead sponsor:
Agency:
University Hospital, Essen
Agency class:
Other
Source:
University Hospital, Essen
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06247163
