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Trial Title:
Early Diagnosis of Gastric Cancer Cachexia
NCT ID:
NCT06277986
Condition:
Cachexia
Conditions: Official terms:
Wasting Syndrome
Cachexia
Study type:
Observational
Overall status:
Recruiting
Study design:
Time perspective:
Retrospective
Intervention:
Intervention type:
Other
Intervention name:
cachexia
Description:
Cachexia mainly manifests as weight loss. 1)weight loss >5% over past 6 months. 2)BMI<20
and any degree of weight loss >2%. 3)Appendicular skeletal muscle index consistent with
sarcopenia and any degree of weight loss >2%.
Arm group label:
Gastric cancer patients with cachexia
Arm group label:
Gastric cancer patients with non-cachexia
Summary:
Gastric cancer is one of the most common malignancies, the morbidity and mortality of
which are among the highest. In cancer patients, the incidence of cachexia is very high,
and even 80% of patients will eventually develop into cachexia. However, once gastric
cancer patients develop cachexia, patients are unlikely to obtain clinically significant
benefits from conventional treatment. Therefore, it is important to find biomarkers for
early detection of cachexia. The investigators carried out a plasma-derived exosomal
microRNA(miRNA) study for early diagnosis of cachexia in gastric cancer, and the
development of early diagnosis kits for gastric cancer cachexia.
Detailed description:
Gastric cancer is one of the most common malignancies, the morbidity and mortality of
which are among the highest. In gastric cancer patients, the incidence of cachexia is
very high, and even 80% of patients will eventually develop into cachexia. However, once
gastric cancer patients develop cachexia, patients are unlikely to obtain clinically
significant benefits from conventional treatment. Therefore, it is important to find
biomarkers for early detection of cachexia. The investigators carried out a
plasma-derived exosomal microRNA(miRNA) study for early diagnosis of cachexia in gastric
cancer, and the development of early diagnosis kits for gastric cancer cachexia.
Criteria for eligibility:
Study pop:
The research object is patients with confirmed gastric cancer.According to diagnostic
criteria, patients are divided into cachexia group and non-cachexia group.
Sampling method:
Non-Probability Sample
Criteria:
Inclusion Criteria:
1. Patients with gastric cancer diagnosed by histopathology or cytopathology
2. Complete clinical and pathological data
3. No previous or current mental illness or disturbance of consciousness
Exclusion Criteria:
1. With multiple tumors or other malignant diseases
2. Combined with other chronic wasting and metabolic diseases
3. Past patients with non-tumor cachexia
4. People with mental illness or unable to cooperate
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Fourth Military Medical University
Address:
City:
Xi'an
Country:
China
Status:
Recruiting
Contact:
Last name:
Jipeng Li
Phone:
+86-029-84771533
Start date:
June 1, 2021
Completion date:
September 1, 2024
Lead sponsor:
Agency:
Xijing Hospital
Agency class:
Other
Source:
Xijing Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06277986
