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Trial Title:
Correlation Between Expression of Hormonal Receptors, Clinical Data, and Methylation Profile in Meningiomas (MethylRH-M)
NCT ID:
NCT06278103
Condition:
Meningioma
Conditions: Official terms:
Meningioma
Conditions: Keywords:
Meningioma
Hormonal receptors
Study type:
Observational [Patient Registry]
Overall status:
Enrolling by invitation
Study design:
Time perspective:
Other
Summary:
This research aims to explore the relationship between hormonal receptor expression and
the clinical and histopathological characteristics of meningiomas. The underlying
hypothesis is that hormonal receptor expression, as well as the methylation profile of
their gene promoters, are associated with specific aspects of meningiomas and patients'
clinical outcomes. The main objective is to study the correlation between the
immunohistochemical expression of hormonal receptors and clinicopathological data. The
secondary objectif is to study the correlation between the methylation profile of
hormonal receptor gene promoters and their immunohistochemical expression.
Criteria for eligibility:
Study pop:
Patients who underwent surgery for a meningioma at the University Hospital of Nancy
between 2000 and 2022.
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- Patients who underwent surgery for a meningioma at the University Hospital of Nancy
between 2000 and 2022.
Exclusion Criteria:
- Patients who did not express their consent to participate in the study.
- Patients with grade 2 or 3 meningiomas whose samples are no longer available or in
insufficient quantity to perform an immunohistochemical study.
- Patients with grade 1 meningiomas not selected by randomization.
- Patients withdrawing their consent.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Start date:
January 1, 2000
Completion date:
September 1, 2024
Lead sponsor:
Agency:
Central Hospital, Nancy, France
Agency class:
Other
Source:
Central Hospital, Nancy, France
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06278103
