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Trial Title:
Adrenal Project: Clinical and Epidemiological Characterization of Adrenocortical Carcinoma in a Brazilian Cohort
NCT ID:
NCT06279442
Condition:
Carcinoma Adrenal
Carcinoma, Adrenocortical Recurrent
Conditions: Official terms:
Carcinoma
Adrenocortical Carcinoma
Conditions: Keywords:
Carcinoma adrenocortical
Study type:
Observational
Overall status:
Not yet recruiting
Study design:
Time perspective:
Other
Summary:
This is a retrospective observational cohort study. The clinical, pathological and
treatment data of participants identified with adrenocortical carcinoma from the year
2000 onwards will be evaluated. Participants recruited for this study will be identified
at the participating sites.
Detailed description:
Adrenocortical carcinoma is one of the rarest neoplasms in the world. In Brazil,
especially in the South and Southeast regions, the incidence of adrenocortical tumors is
around 15 times higher than in the rest of the world, largely attributed to the
significant prevalence of the TP53-R337H germline mutation in this population. In view of
this characteristic, the clinical and epidemiological characterization of this cohort, as
well as the identification of prognostic factors, is of great importance. The starting
point for this project was the cohort of 66 participants with adrenal carcinoma included
in the final project of the medical residency in clinical oncology at the A.C. Camargo
Cancer Center by student Rafael Haikal dos Santos Abduch. The aim is to include case
studies from the main Brazilian site that have followed up and treated patients with
adrenal carcinoma.
Criteria for eligibility:
Study pop:
Data will be included from 150 participants diagnosed with adrenocortical carcinoma who
meet the study's inclusion and exclusion criteria. Data will be collected from the
medical records of the included research sites throughout Brazil.
Sampling method:
Probability Sample
Criteria:
Inclusion Criteria:
- Participants over 18 years old;
- Diagnosis of adrenocortical carcinoma with at least one clinical evaluation at the
reference institution;
- Initial diagnosis or recurrence from the year 2000 onwards.
Exclusion Criteria:
- Participants with insufficient clinical or pathological data in the medical records.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
A.C. Camargo Cancer Center
Address:
City:
São Paulo
Zip:
01.509-001
Country:
Brazil
Investigator:
Last name:
Milena Shizue Tariki
Email:
Principal Investigator
Start date:
September 2024
Completion date:
November 2025
Lead sponsor:
Agency:
Latin American Cooperative Oncology Group
Agency class:
Other
Source:
Latin American Cooperative Oncology Group
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06279442
