Toripalimab Combined With SBRT for NSCLC

Trial Title: Toripalimab Combined With SBRT for NSCLC

NCT ID: NCT06293690

Condition: Non-small Lung Cancer

Conditions: Official terms:
Lung Neoplasms

Study type: Interventional

Study phase: Phase 2

Overall status: Not yet recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Toripalimab
Description: Patients received preoperative neoadjuvant therapy: SBRT 12gy on the first day, and Toripalimab (iv 240mg, q3W) combined with platinum-containing dual drugs on the second day. Two cycles in total.
Arm group label: SBRT combined with immunochemotherapy

Other name: SBRT

Other name: platinum-containing dual drugs

Intervention type: Drug
Intervention name: Toripalimab
Description: Patients received preoperative neoadjuvant therapy: SBRT 12gy on the first day, and Toripalimab (iv 240mg, q3W) on the second day. Two cycles in total.
Arm group label: SBRT combined with immunotherapy

Other name: SBRT

Summary: This study aimed to evaluate the efficacy and safety of Toripalimab injection (js001) combined with SBRT radiotherapy and neoadjuvant therapy with or without chemotherapy for operable or potentially operable stage IIa to IIIb NSCLC

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. Age range from 18 to 75 years old, regardless of gender; 2. ECOG behavior status score 0-1 points; 3. Non small cell lung cancer diagnosed pathologically and clinically classified as stage IIA-IIIB (8th AJCC staging standard); 4. Sufficient tumor tissue can be provided for biomarker analysis; 5. Patients with distant metastasis are excluded through CT or PET/CT, and their physical condition is evaluated as acceptable for radical lung cancer surgery; 6. Primary lung lesions are suitable for SBRT treatment; 7. Confirming the absence of EGFR/ALK/ROS-1 sensitive gene mutations through molecular pathological diagnosis of the organization; 8. The main organ functions within 7 days before the first administration meet the following standards: a Bone marrow function: hemoglobin ≥ 10.0 g/dL (no blood transfusion received within 28 days before hemoglobin test), absolute neutrophil count ≥ 1.5 × 109/L, platelet count ≥ 100 × 109/L (no platelet transfusion or IL-11 treatment received within 14 days prior to platelet count test);b Coagulation function: INR and PT<1.5 × ULN, APTT ≤ 1.5 × ULN;c Liver function: transaminases (ALT and AST) ≤ 2.5 × ULN; Total bilirubin ≤ 1.5 × ULN (total bilirubin ≤ 2.5 in subjects with Gilbert's syndrome or liver metastasis) × ULN);d Renal function: serum creatinine clearance rate ≥ 60 mL/min (calculated according to Cockcroft Fault formula);e Adequate lung function: According to the doctor's judgment, lung function can meet the requirements of thymectomy surgery. Exclusion Criteria: 1. Pathological findings indicate complex small cell lung cancer, etc; 2. History of previous lobectomy surgery and previous experience with radiotherapy and chemotherapy; 3. Patients with concurrent secondary primary cancer and a history of malignant tumors less than 5 years (excluding completely cured cervical carcinoma in situ or basal or squamous cell skin cancer); 4. The patient has any active autoimmune diseases or a history of autoimmune diseases (such as interstitial pneumonia, uveitis, enteritis, hepatitis, pituitary inflammation, vasculitis, myocarditis, nephritis, hyperthyroidism, hypothyroidism, etc.); 5. Have active infection or active tuberculosis history requiring systemic treatment; 6. Those who have combined the following active infectious diseases, including those who are highly positive for hepatitis, known human immunodeficiency virus (HIV) infections, and sexually transmitted diseases such as active syphilis; 7. Those who are known to have or combine with other uncontrollable diseases and are unable to receive surgical treatment; 8. Physical examination or clinical trial findings that researchers believe may interfere with the results or increase the risk of treatment complications for patients; 9. Previous history of interstitial lung disease, drug-induced interstitial disease, or any clinically proven active interstitial lung disease, baseline CT scan reveals the presence of idiopathic pulmonary fibrosis; Uncontrolled large amounts of pleural or pericardial effusion; 10. Unstable systemic comorbidities (active infection period, moderate to severe chronic obstructive pulmonary disease, poorly controlled hypertension, unstable angina, congestive heart failure, myocardial infarction occurring within 6 months, severe mental disorders requiring drug control, metabolic diseases of the liver, kidney or other organs, neuropsychiatric disorders such as Alzheimer's disease); 11. History of congenital or acquired immunodeficiency diseases or organ transplantation; 12. Have received any of the following treatments:a Previously received chemotherapy, anti-PD-1, anti-PD-L1 or anti-PD-L2 drugs, or other drugs that synergistically inhibit T cell receptors such as CTLA-4, OX-40, and CD137; Received any investigational medication within 4 weeks prior to the first use of the investigational medication;b Simultaneously enroll in another clinical study, unless it is an observational (non-intervention) clinical study or an intervention clinical study follow-up;c Individuals who have received anti-tumor vaccines or have received live vaccines within 4 weeks prior to the first administration of the investigational drug;d Having undergone major surgery or severe trauma within 4 weeks before the first use of the investigational drug;

Gender: All

Minimum age: 18 Years

Maximum age: 75 Years

Healthy volunteers: No

Locations:

Facility:
Name: Shanghai Pulmonary Hospital

Address:
City: Shanghai
Zip: 200000
Country: China

Contact:
Last name: Deping Zhao

Phone: 0086-20-65115006
Email: zdp1992@163.com

Investigator:
Last name: Deping Zhao
Email: Principal Investigator

Start date: March 15, 2024

Completion date: June 30, 2026

Lead sponsor:
Agency: Shanghai Pulmonary Hospital, Shanghai, China
Agency class: Other

Source: Shanghai Pulmonary Hospital, Shanghai, China

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06293690