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Trial Title: A Phase Ib/II Clinical Study of GH21 Capsules Combined With Osimertinib Mesylate Tablets in Patients With NSCLC

NCT ID: NCT06306456

Condition: Non-Small Cell Lung Cancer With EGFR Mutation

Conditions: Official terms:
Carcinoma, Non-Small-Cell Lung
Osimertinib

Study type: Interventional

Study phase: Phase 1/Phase 2

Overall status: Recruiting

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: GH21
Description: Oral, 15mg BIW/6mg QD
Arm group label: 'GH21+Osimertinib'Group

Intervention type: Drug
Intervention name: Tagrisso
Description: Oral, 80mg QD
Arm group label: 'GH21+Osimertinib'Group

Summary: This study, including phase Ib , phase IIa and phase IIb, aims to evaluate the safety, tolerability, PK profile, efficacy and to determine the RP2D of GH21 capsules combined with Osimertinib mesylate tablets in NSCLC patients with EGFR mutations.

Detailed description: Phase Ib: Classic "3+3" design used for Phase 1b to select the putative RDEs. Four dose groups are preset in phase Ib of this study, which including QD groups and BIW groups. Subjects will be enrolled in parallel cross into the group. Phase IIa: Two cohorts are preset in this stage, Cohort 1: GH21 RDE1 QD + Osimertinib 80 mg QD, Cohort 2: GH21 RDE2 D1D2-BIW + Osimertinib 80 mg QD, Cohort 1 and Cohort 2 are enrolled in parallel. Phase IIb: Phase IIb preset 1 cohort. The investigator and sponsor will comprehensively evaluate safety, efficacy, and PK data from Phases Ib and IIa to determine the dose level for Phase IIb.

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. Subjects or their legal representatives can understand and voluntarily sign the written ICF (before the start of screening and any study procedures); 2. Male or female subjects aged ≥18 years; 3. Advanced NSCLC patients with EGFR mutations confirmed by cytological or histological assessments, and meet the following requirement: - Phase Ib: patients with disease progression previously at least treated with third-generation EGFR-TKIs and platinum-containing chemotherapy; - Phase IIa and IIb:patients with disease progression previously at least treated with a third-generation EGFR-TKIs (Osimertinib, Furmonertinib Almonertinib etc.). 4. Patients have at least one measurable lesion as defined by RECIST v1.1 (a tumor lesion in the area that has undergone radiotherapy or other loco-regional therapies, is generally not considered as measurable unless there is a disease progression in the lesion); 5. Consent to provide samples for genetic testing; 6. Life expectancy of ≥ 3 months; 7. ECOG PS score of 0-1; 8. The subjects must have adequate organ functions; 9. Male and female of reproductive potential must agree to take reliable contraceptive measures (hormone or barrier methods or abstinence) from signing the ICF until 30 days after the last dose. Pregnancy test results must be negative for female of reproductive potential within 7 days prior to the first dose of the investigational product. Exclusion Criteria: 1. Subjects who receive any chemotherapy or antitumor biologics within 3 weeks, or antitumor therapies such as radiotherapy and endocrine therapy within 4 weeks prior to the first dose of the investigational product, except for the following: - Use of nitrosoureas or mitomycin C within 6 weeks prior to the first dose of the investigational product; - Oral administration of fluorouracils, small molecule targeted drugs, and Chinese herbal medicines or Chinese patent medicines with antitumor indications within 5 half-lives or 2 weeks before the first dose of the investigational product (whichever is shorter); - Small molecule TKI inhibitors within 5 half-lives or 2 weeks prior to the first dose of the investigational product (whichever is shorter); - Local palliative radiotherapy within 2 weeks prior to the first dose of the investigational product; 2. Subjects who have had another investigational new drug or therapy within 4 weeks prior to the first dose of the investigational product; 3. Subjects who have had a major organ surgery (excluding needle biopsy) or significant trauma within 4 weeks prior to the first dose of the investigational product, or require an elective surgery during the study; 4. Subjects who have received strong CYP3A4 inhibitors or inducers and strong P-gp inhibitors or inducers within 2 weeks or within 5 half-lives (whichever is longer) prior to the first dose of the investigational product; 5. Subjects with evidence of the following heart conditions: - Acute myocardial infarction, unstable angina pectoris, coronary artery bypass grafting, cerebrovascular accident, or transient ischemic attack within 6 months prior to the first dose of the investigational product; - Grade III-IV heart failure diagnosed according to the cardiac function classification of the New York Heart Association at screening; - Echocardiography (ECHO) shows the left ventricular ejection fraction (LVEF) ≤ 50% at screening; - QT interval corrected by Fridericia method (QTcF) is ≥ 450 ms (male) or ≥ 470 ms (female) at screening; - Uncontrolled hypertension (systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg) despite of medication treatment at screening; 6. Subjects with dysphagia, gastrointestinal disorders that affect drug absorption, or other malabsorption conditions, such as intestinal obstruction, Crohn's disease, ulcerative colitis, short bowel syndrome, delayed gastric emptying, or severe gastrointestinal toxicities that have not resolved to Grade 2 or lower prior to the first dose of the investigational product; or subjects are diagnosed with a clinically significant or acute gastrointestinal disease; 7. Subjects with poorly controlled clinical pleural ascites assessed by the investigator; 8. Subjects with active central nervous system metastasis and/or carcinomatous meningitis (e.g., brain metastases accompanied by central nervous system symptoms, including headache, vomiting and dizziness, etc.); 9. Subjects with interstitial pneumonia, or any evidence of clinically active interstitial lung disease within 6 months before the first dose of the investigational product; 10. Subjects with a history of other malignancies (excluding those deemed eligible by the investigator, such as skin squamous cell carcinoma in situ, basal cell carcinoma, and cervical cancer in situ that have been cured and have not relapsed for 5 years; or subjects deemed eligible by the investigator in Phase Ib); 11. Subjects with a history of severe allergies, a history of allergies to Osimertinib, or to multiple drugs; 12. Subjects with hepatitis B virus infection (HBsAg positivity and DNA copies < 100 IU/mL); or hepatitis C virus infection (HCV antibody positivity, and HCV RNA > ULN); or human immunodeficiency virus infection (HIV antibody positivity); 13. Subjects with active infections requiring anti-infective treatment (Grade ≥ 2) or fever > 38°C of unknown etiology within 28 days prior to the first dose of the investigational product; 14. Subjects with any toxicity caused by a previous antitumor therapy that has not resolved to Grade ≤ 1 according to CTCAE 5.0 (except for alopecia, Grade 2 peripheral neuropathy, and/or other Grade ≤ 2 AEs of insignificant safety risks) before the first dose of the investigational product; 15. Female subjects who are pregnant or breastfeeding; 16. Subjects who are not suitable for this study due to any clinical or laboratory abnormalities or other reasons as assessed by the investigator.

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: The Second Hospital of Anhui Medical University

Address:
City: Hefei
Zip: 230601
Country: China

Status: Not yet recruiting

Contact:
Last name: Mingjun Zhang, Doctorate

Phone: (86)0551-63869420
Email: mjzhang2010@outlook.com

Facility:
Name: The First Affiliated Hospital of Zhengzhou University

Address:
City: Zhengzhou
Zip: 450000
Country: China

Status: Not yet recruiting

Contact:
Last name: Sanxing Guo, Doctorate

Phone: (86)0371-67966266
Email: sanxing134@hotmail.com

Facility:
Name: Hunan Cancer Hospital

Address:
City: Changsha
Zip: 410031
Country: China

Status: Recruiting

Contact:
Last name: Yongchang Zhang, Doctorate

Phone: (86)0731-88651900
Email: zhangyongchang@csu.edu.cn

Facility:
Name: Nanjing Drum Tower Hospital

Address:
City: Nanjing
Zip: 210008
Country: China

Status: Recruiting

Contact:
Last name: Yongsheng Wang, Doctorate

Phone: (86)025-83304616
Email: dolphin8012@yahoo.com

Facility:
Name: Shanghai Pulmonary Hospital

Address:
City: Shanghai
Zip: 200433
Country: China

Status: Recruiting

Contact:
Last name: Caicun Zhou, Doctorate

Phone: (86)021-65115006
Email: caicunzhoudr@163.com

Facility:
Name: Taizhou Hospital of Zhejiang Province

Address:
City: Linhai
Zip: 317099
Country: China

Status: Recruiting

Contact:
Last name: Dongqing Lv, Master's degree

Phone: (86)0576-85120120
Email: lvdq@enzemed.com

Start date: March 5, 2024

Completion date: December 31, 2026

Lead sponsor:
Agency: Suzhou Genhouse Bio Co., Ltd.
Agency class: Other

Source: Suzhou Genhouse Bio Co., Ltd.

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06306456

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