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Trial Title: A Phase Ib/II Clinical Study of HRS-1167 in Combination With Bevacizumab in Patients With Recurrent Ovarian Cancer

NCT ID: NCT06308406

Condition: Recurrent Ovarian Cancer

Conditions: Official terms:
Ovarian Neoplasms
Carcinoma, Ovarian Epithelial
Recurrence
Bevacizumab

Study type: Interventional

Study phase: Phase 1/Phase 2

Overall status: Recruiting

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Bevacizumab; HRS-1167
Description: Bevacizumab: injection, 100mg(4mL), intravenous infusion HRS-1167: Tablets, 25mg/tablet, oral
Arm group label: HRS-1167 in combination with bevacizumab in patients with recurrent ovarian cancer

Summary: This study is a multicenter, open-label Phase Ib/II clinical trial to observe and evaluate the safety, tolerability and pharmacokinetics of HRS-1167 in combination with bevacizumab in patients with recurrent ovarian cancer mechanical characterization and preliminary evaluation of the efficacy of HRS-1167 in combination with bevacizumab in patients with recurrent ovarian cancer.

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. Voluntarily join this study, sign the informed consent form, have good compliance, and be able to cooperate with the follow-up. 2. Age 18~75 years old. 3. Cytologically or histologically confirmed diagnosis of recurrent epithelial ovarian, fallopian tube, or primary peritoneum cancer. 4. Patient has been previously treated with a platinum-containing regimen and has been treated with a platinum-based regimen during the last dose of platinum-based therapy (self-treatment initiation to within 1 month after the last dose) efficacy is non-PD, 6 months after the end of treatment (183 disease progression or recurrence within calendar days, and the number of lines of systemic therapy after platinum resistance ≤1 line. 5. At least one measurable lesion per RECIST v1.1 criteria. 6. ECOG PS score: 0-1 points. 7. Expected survival period ≥ 3 weeks. 8. Good level of organ function. 9. Subjects of childbearing potential who need to use highly effective contraception from the time of signing informed to 210 days after the last dose of trial drug; Subjects of childbearing potential must have a negative serum HCG within 7 days prior to the first dose and must be non-lactating. Exclusion Criteria: 1. Those who have received chemotherapy, immune checkpoint inhibitors, major surgical operations, anti-tumor vaccines within 4 weeks before the first dose; Those who have received palliative radiotherapy within 2 weeks prior to the first dose; Oral molecularly targeted therapy (including other clinical trial targeted agents) 5 drug half-lives or 4 weeks (whichever is shorter) < from the first study dose; Those who have received a live vaccine within 4 weeks prior to the first dose or possibly during the study. 2. Toxicity due to prior antineoplastic therapy has not recovered according to NCI-CTCAE v5.0 grade≤ Level 1. 3. Subject has previous or concurrent other malignancies. 4. Subject has carcinomatous meningitis, or has untreated central nervous system metastases. 5. Imaging shows tumor invasion of large blood vessels or unclear demarcation from blood vessels; or the investigator judges that the patient's tumor has a high possibility of invading important blood vessels and causing fatal hemorrhage during treatment. 6. Cancerous ascites and pleural effusion with clinical symptoms, requiring puncture and drainage; or those who have received ascites, pleural effusion drainage within 14 days before the first dose of the drug. 7. Severe bone injury due to tumor bone metastases, including severe bone pain with poor control, pathological fractures of important sites and spinal cord that have occurred within the last 6 months or are expected to occur in the near future oppression, etc. 8. Previous or current interstitial pneumonitis/interstitial lung disease (except for those with radiographic changes only), pneumonia requiring systemic treatment with glucocorticoids (such as radiation pneumonitis, etc.); Current active pneumonitis or those with severe impairment of lung function confirmed by pulmonary function tests. 9. People who are known to be allergic to bevacizumab or have had a severe allergic reaction to other monoclonal antibodies. 10. Those with active tuberculosis; Those who have been adequately treated before the first dose and have discontinued anti-tuberculosis therapy for ≥ 3 months can be enrolled. 11. Have hypertension that is not well controlled with antihypertensive medication (systolic blood pressure ≥ 150 mmHg or diastolic blood pressure ≥ 90 mmHg); Previous hypertensive crisis or hypertensive sex encephalopathy. 12. Have clinical symptoms or disease of the heart that are not well controlled. 13. Coagulation abnormalities, bleeding tendency, or those receiving thrombolytic or anticoagulant therapy are allowed to receive low-dose low-molecular-weight heparin or oral aspirin prophylactic anticoagulation therapy during the trial. 14. NCI-CTCAE v5.0 grade ≥2 bleeding events within 4 weeks prior to the first dose, including but not limited to hemoptysis (hemoptysis in a single episode ≥2mL), vaginal bleeding, gastrointestinal bleeding, etc. 15. Experienced arterior/venous thrombotic event within 6 months prior to the first dose. 16. Patients with gastrointestinal perforation or fistula (except artificial fistula), urethral fistula, intra-abdominal abscess, intestinal obstruction, or those requiring parenteral nutrition within 3 months prior to the first dose. 17. Those who are unable to swallow tablets normally, or have abnormal gastrointestinal function, which may affect drug absorption as judged by the investigator. 18. Subjects who have had a serious infection within 1 month before the first dose, including but not limited to infectious complications requiring hospitalization, bacteremia, severe pneumonia, etc.; Subjects with any active infection requiring intravenous system therapy, or who have a progeny during the screening period, prior to the first dose 38.5°C due to unknown fever>; Those who have used antibiotics within 2 weeks before the first dose. 19. Known history of positive human immunodeficiency virus (HIV) test; Known active hepatitis. 20. Treatment with a strong inhibitor of CYP3A4, CYP2D6, P-gp, or BCRP, <5 drug half-lives or 14 days from the date of first dose; Treatment with the above enzyme strong inducers was 28 days < the first dose. 21. As judged by the investigator, there are other factors that may affect the results of the study or cause the study to be terminated halfway, such as alcoholism, drug abuse, other serious diseases (such as severe diabetes, thyroid disease, spinal cord compression, superior vena cava syndrome, psychiatric diseases) that require concomitant treatment, serious laboratory test abnormalities, accompanied by family or social factors, which will affect the safety of the subjects.

Gender: Female

Minimum age: 18 Years

Maximum age: 75 Years

Healthy volunteers: No

Locations:

Facility:
Name: First Affiliated Hospital of University of Science and Technology of China

Address:
City: Hefei
Zip: 230002
Country: China

Status: Not yet recruiting

Investigator:
Last name: Ying Zhou
Email: Principal Investigator

Facility:
Name: Cancer Hospital Chinese Academy of Medical Sciences

Address:
City: Beijing
Zip: 100021
Country: China

Status: Not yet recruiting

Investigator:
Last name: Lingying Wu
Email: Principal Investigator

Facility:
Name: Beijing Cancer Hospital

Address:
City: Beijing
Zip: 100142
Country: China

Status: Not yet recruiting

Investigator:
Last name: Hong Zheng
Email: Principal Investigator

Facility:
Name: Chongqing University Cancer Hospital

Address:
City: Chongqing
Zip: 400000
Country: China

Status: Not yet recruiting

Investigator:
Last name: Yu Huang
Email: Principal Investigator

Facility:
Name: The First Affiliated Hospital of Chongqing Medical University

Address:
City: Chongqing
Zip: 400016
Country: China

Status: Not yet recruiting

Investigator:
Last name: Junying Tang
Email: Principal Investigator

Facility:
Name: Guangxi Medical University Affiliated Tumor Hospital

Address:
City: Nanning
Zip: 530022
Country: China

Status: Not yet recruiting

Investigator:
Last name: He Wang
Email: Principal Investigator

Facility:
Name: The Fourth Hospital of Hebei Medical University

Address:
City: Shijiazhuang
Zip: 050001
Country: China

Status: Not yet recruiting

Investigator:
Last name: Hui Zhang
Email: Principal Investigator

Facility:
Name: Harbin Medical University Cancer Hospital

Address:
City: Harbin
Zip: 150001
Country: China

Status: Not yet recruiting

Investigator:
Last name: Ge Lou
Email: Principal Investigator

Facility:
Name: Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology

Address:
City: Wuhan
Zip: 430030
Country: China

Status: Not yet recruiting

Investigator:
Last name: Qinglei Gao
Email: Principal Investigator

Facility:
Name: Hunan Cancer Hospital

Address:
City: Changsha
Zip: 410013
Country: China

Status: Recruiting

Investigator:
Last name: Jing Wang
Email: Principal Investigator

Facility:
Name: Liaoning Cancer Hospital

Address:
City: Shenyang
Zip: 110042
Country: China

Status: Not yet recruiting

Investigator:
Last name: Danbo Wang
Email: Principal Investigator

Facility:
Name: Qilu Hospital of Shandong University

Address:
City: Jinan
Zip: 250000
Country: China

Status: Not yet recruiting

Investigator:
Last name: Hualei Bu
Email: Principal Investigator

Facility:
Name: Shandong First Medical University Affiliated Cancer Hospital

Address:
City: Jinan
Zip: 250117
Country: China

Status: Not yet recruiting

Investigator:
Last name: Liang Chen
Email: Principal Investigator

Facility:
Name: Shanxi Provincial Cancer Hospital

Address:
City: Taiyuan
Zip: 030006
Country: China

Status: Not yet recruiting

Investigator:
Last name: Hongwei Zhao
Email: Principal Investigator

Facility:
Name: Sichuan Cancer Hospital

Address:
City: Chengdu
Zip: 610042
Country: China

Status: Not yet recruiting

Investigator:
Last name: Guonan Zhang
Email: Principal Investigator

Facility:
Name: Tianjin Cancer Hospital

Address:
City: Tianjin
Zip: 300000
Country: China

Status: Not yet recruiting

Investigator:
Last name: Ke Wang
Email: Principal Investigator

Facility:
Name: Yunnan Cancer Hospital

Address:
City: Kunming
Zip: 650118
Country: China

Status: Not yet recruiting

Investigator:
Last name: Hongying Yang
Email: Principal Investigator

Facility:
Name: Zhejiang Cancer Hospital

Address:
City: Hangzhou
Zip: 310005
Country: China

Status: Not yet recruiting

Investigator:
Last name: Tao Zhu
Email: Principal Investigator

Start date: March 15, 2024

Completion date: October 2025

Lead sponsor:
Agency: Jiangsu HengRui Medicine Co., Ltd.
Agency class: Industry

Source: Jiangsu HengRui Medicine Co., Ltd.

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06308406

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