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Trial Title: Clinical Study of Postoperative Carbon Ion Radiotherapy for Thymus Tumor With Residual Tumor

NCT ID: NCT06311955

Condition: Thymic Epithelial Tumor
Radiotherapy Side Effect
Carbon Ion Radiotheray
Heavy Ion Radiotherapy

Study type: Interventional

Study phase: Phase 2

Overall status: Recruiting

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Radiation
Intervention name: Carbon ion radiotherapy
Description: The patients will receive 72GyE per 18 fractions of carbon ion radiotherapy. Patients with thymus cancer should be combined with platinum-based regimen (including etoposide combined with cisplatin / carboplatin / loplatin / nedaplatin; paclitaxel combined with cisplatin or cisplatin / carboplatin / loplatin / nedaplatin; docetaxel combined with cisplatin / carboplatin / loplatin / nedaplatin) for at least 4 cycles. The primary endpoint was progression-free survival and toxicities, and the secondary endpoint was local relapse-free survival, overall survival and cause-specific survival.
Arm group label: Study arm

Intervention type: Other
Intervention name: combined with platinum-based regimen
Description: combined with platinum-based regimen
Arm group label: Study arm

Summary: To observe the efficacy and toxicities of heavy ion radiation therapy for locally advanced or advanced primary thymic epithelial malignant tumor received R2 resection. The primary endpoint was progression-free survival and toxicities, and the secondary endpoint was local relapse-free survival, overall survival and cause-specific survival.

Detailed description: The patients will receive 72GyE per 18 fractions of carbon ion radiotherapy. Patients with thymus cancer should be combined with platinum-based regimen (including etoposide combined with cisplatin / carboplatin / loplatin / nedaplatin; paclitaxel combined with cisplatin or cisplatin / carboplatin / loplatin / nedaplatin; docetaxel combined with cisplatin / carboplatin / loplatin / nedaplatin) for at least 4 cycles. The primary endpoint was progression-free survival and toxicities, and the secondary endpoint was local relapse-free survival, overall survival and cause-specific survival.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Patients with stage II-IV (Masaoka-Koga) thymus epithelial malignancies without a history of thoracic radiotherapy who had undergone radical surgery (R2 resection, visible residual tumor) and had a definite pathological diagnosis. - Sign informed consent. - Between the ages of 18 and 70. - ECOG general status score of 0-2. - The expected survival is at least 6 months. - Adequate organ function: 1). Blood function: absolute neutrophil count (ANC) ≥1.5 x 109/L, platelet count ≥80 x 109/L, hemoglobin ≥9 g/dL 2). Lung function: FEV1>25%, DLCO>25% 3). Cardiac function: no serious pulmonary hypertension, cardiovascular and cerebrovascular diseases, peripheral vascular diseases, serious chronic heart disease and other complications that may affect radiotherapy.4). Adequate liver function: total bilirubin <1.5 times the upper limit of normal value, and AST, ALT<2 times the upper limit of normal value. 5). Adequate renal function: serum creatinine ≤1.5 times the upper limit of normal or calculated creatinine clearance ≥50 ml /min, and urinary protein <2+. Patients with a baseline urinary protein level of 2+ or more should have a 24-hour urine collection and evidence of a 24-hour urinary protein level of 1g or less. Exclusion Criteria: - Complicated with other malignant tumors that have not been controlled. - Have large quantity of pleural or pericardial effusion. - Patient whose particle radiotherapy plan cannot meet the minimum target dose coverage and dose volume limitation requirements, or cannot meet the dose constrains of normal tissue or organs. - Chest radiation therapy or radioactive particle implantation history. - Cardiac pacemakers or other internal metal prosthesis implants that may be affected by high-energy radiation or may affect the dose distribution to the radiation target area. - Pregnancy (confirmed by serum or urine β-HCG test) or lactation period. - HIV positive. Hepatitis virus replication phase, need to receive antiviral therapy, but because of concomitant disease cannot receive antiviral therapy. Active stage of syphilis. - A history of mental illness may hinder the completion of treatment. - With serious comorbidity that may interfere with radiotherapy, including: (a) Acute infectious diseases or acute active phase of chronic infection. b) Unstable angina pectoris, congestive heart failure, myocardial infarction that has been hospitalized in the past 6 months. c) Exacerbations of chronic obstructive pulmonary disease or other respiratory conditions requiring hospitalization. d) Severely impaired immune function. e) Diseases with excessive sensitivity to radiation such as ataxia telangiectasia. f) Other diseases that may affect particle radiotherapy. - Other circumstances that the physician considers inappropriate to participate in clinical study.

Gender: All

Minimum age: 18 Years

Maximum age: 70 Years

Healthy volunteers: No

Locations:

Facility:
Name: Shanghai Proton and Heavy Ion Center

Address:
City: Shanghai
Zip: 201513
Country: China

Status: Recruiting

Contact:
Last name: Jing Li

Phone: 86-21-38296678
Email: jing.li@sphic.org.cn

Contact backup:
Last name: Kun Liu

Phone: 86-21-38296678
Email: kun.liu@sphic.org.cn

Investigator:
Last name: Jian Chen, MD
Email: Principal Investigator

Investigator:
Last name: Jingfang Mao, PHD
Email: Principal Investigator

Investigator:
Last name: Kai-liang Wu, PHD
Email: Principal Investigator

Start date: April 1, 2024

Completion date: February 28, 2029

Lead sponsor:
Agency: Jian Chen
Agency class: Other

Source: Shanghai Proton and Heavy Ion Center

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06311955

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