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Trial Title:
A Phase Ⅲ Study of Hemay022 in Combination With AI In Advanced Breast Cancer
NCT ID:
NCT06313983
Condition:
Breast Cancer
Conditions: Official terms:
Breast Neoplasms
Capecitabine
Lapatinib
Study type:
Interventional
Study phase:
Phase 3
Overall status:
Recruiting
Study design:
Allocation:
Randomized
Intervention model:
Parallel Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
Hemay022+AI
Description:
hemay022:orally once daily,A 21-day cycle
Arm group label:
Hemay022 and AI
Intervention type:
Drug
Intervention name:
Lapatinib+Capecitabine
Description:
Take the pills according to the instructions
Arm group label:
Lapatinib and Capecitabine
Summary:
The purpose of this study is to evaluate the effectiveness of Hemay022 combined with AI
(exemestane or letrozole) in the treatment of ER+/HER2+ advanced breast cancer patients
based on the progression-free survival (PFS) assessed by the independent review committee
(IRC). The second purpose of this study is to evaluate the pharmacokinetics and efficacy
of Hemay022 in combination with AI, and the safety of Hemay022 in combination with AI.
The trial plans to recruit 339 subjects, who will be randomly divided into two cohorts
(the experimental group is hemay022 combined with AI, and the control group is lapatinib
combined with capecitabine). During the treatment period, imaging examinations and
anti-tumor efficacy evaluations will be performed regularly until the subject develop
disease progression or starts receiving other treatments or dies or refuses to come to
the hospital for follow-up or the trial is terminated, etc.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
1. Age ≥18 years old;
2. Subjects must give informed consent to the study before the study entry and
voluntarily sign a written informed consent form;
3. Breast cancer subjects diagnosed by pathology(histology or cytology);
4. ER positive and HER2 over-expression (immunohistochemical IHC test 3+ and/or in situ
hybridization ISH test positive);Previous test results are acceptable.
5. Advanced/metastatic breast cancer that has previously received treatment failure
with trastuzumab (or trastuzumab biosimilar) regimen;Or (new) adjuvant therapy
during treatment with trastuzumab (or trastuzumab biosimilar) or within 12 months
after the end of treatment, disease recurrence or progression;Patients with
first-line systemic treatment for relapse (previously received trastuzumab or
trastuzumab biosimilars);Or patients who are not suitable for trastuzumab
treatment;Patients who have failed previous anti-HER2-ADC drug therapy can also be
included.
6. At least one lesion (measurable and/or non-measurable) that can be evaluated by
CT/MRI and meets the reproducible evaluation requirements of RECIST V1.1;
7. ECOG Performance Status of 0-1;
8. The estimated survival time is more than 3 months;
9. Postmenopausal women
Postmenopausal is defined as meeting any one of the following four conditions:
Past bilateral oophorectomy; Age ≥60 years old; Age <60 years old, natural menopause
≥12 months, in the past 1 year without chemotherapy, tamoxifen, toremifene or
ovarian castration, the level of follicle stimulating hormone (FSH) and estradiol
Within the postmenopausal range (use the reference range of the local laboratory).
Patients younger than 60 years old who are taking tamoxifen or toremifene, their FSH
and estradiol levels are within the postmenopausal range (use the reference range of
the local laboratory); Premenopausal or perimenopausal women who do not meet the
above-mentioned menopausal criteria can also be included in this study, but they
must also receive ovarian suppression therapy that meets the standards of medical or
surgical castration treatment. Drug ovarian suppression therapy has been started at
least 21 days before the start of this program, and Must be continued during the
treatment plan;
10. Adequate bone marrow, liver, kidney, and coagulation Bone Marrow Function (No blood
transfusion or adjuvant leukocyte or platelet augmentation drugs were used within 1
week before screening) Absolute value of neutrophils (ANC) ≥1.5×109/L Hemoglobin
(HB) ≥90g/L (transfusion allowed) Platelet (PLT) ≥80×109/L Liver function Liver
function grade Child-Pugh A/B (≤9 points) Alanine transferase (ALT) or aspartate
aminotransferase (AST) ≤2.5 ULN in the absence of liver metastasis; ALT or AST≤ 5x
ULN with liver metastasis Renal function: serum creatinine ≤1.5 times ULN;
11. All previous treatment-related toxicities must be CTCAE (version 5.0) ≤ Grade 2 at
the time of randomization, except for hair loss, pigmentation, and long-term
toxicity caused by radiotherapy (which cannot be recovered by the investigator's
judgment);
12. Women patients of childbearing age (including their partners) have no pregnancy plan
and voluntarily take effective contraceptive measures from the signing of the
informed consent form to 3 months after the last medication.
Exclusion Criteria:
1. Patients with visceral crisis(Visceral crisis is defined as the dysfunction of
several organs confirmed by symptoms, signs, laboratory tests, and rapid disease
progression.Visceral crisis does not simply refer to the presence of visceral
metastases, but to critical visceral conditions that require rapid and effective
treatment to control the disease progression, especially when the opportunity for
chemotherapy is lost after progression)
2. Patients with the presence of spinal cord compression or brain, meningeal metastases
3. Patients who have been treated with a small molecule HER2 tyrosine kinase inhibitor
(HER2-TKI) (medication course ≤2 weeks is excluded)
4. Have received radiotherapy within 4 weeks prior to study;
5. Have received chemotherapy for advanced breast cancer> 1 lines (the subjects who
have used chemotherapy drugs must have stopped the chemotherapy drugs for ≥ 4 weeks
before being enrolled in this study);
6. Patients with parenteral nutrition; malabsorption syndrome; or any condition
possibly affecting drug absorption or inability to tolerate oral medications;
7. Use of any drug that inhibits or induces hepatic metabolism of Hemay022 within 2
weeks prior to study and entire study duration, for example CYP3A4 strong inhibitors
or strong inducers;
8. Patients who are known to have a history of allergies to Hemay022, lapatinib、AI
(letrozole, exemestane) capecitabine or similar drugs.
9. Left ventricular ejection fraction (LVEF) <50% as measured by echocardiogram or MUGA
scan.
10. Positive blood for human immunodeficiency virus (HIV antibody); Positive hepatitis B
surface antigen and HBV-DNA>upper limit of normal; Active hepatitis C virus (HCV)
infection
11. Patients with active infection requiring intravenous anti-infective treatment
12. Arrhythmias requiring treatment , including atrial fibrillation, supraventricular
tachycardia ,ventricular tachycardia, ventricular fibrillation, or patients with
coronary heart disease have symptoms requiring medicine treatment, myocardial
infarction within 1 year, congestive heart failure (CHF)
13. Confirmed QTc prolongation (≥500ms) (heart rate corrected according to Bazett
formula or Fridericia formula)
14. People with a history of interstitial lung disease that needs treatment, a history
of radiation pneumonitis, or clinically active interstitial lung disease
15. Have received other clinical trial drugs within 4 weeks before the study
16. Major surgery or injury less than 4 weeks before the study
17. The study period must be accompanied by other antitumor therapy,such as
chemotherapy, targeted therapy, hormone therapy, immunotherapy, radiotherapy (except
symptomatic local radiotherapy)
18. Any other malignant cancer within 5 years with the exception of adequately treated
cervical cancer in situ or basal and squamous cutaneous cell carcinomas
19. Any condition that would make the subject inappropriate for this study by the
investigator's judgment
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
Beijing Cancer Hospital
Address:
City:
Beijing
Country:
China
Status:
Recruiting
Contact:
Last name:
Huiping Li
Start date:
January 8, 2022
Completion date:
June 2026
Lead sponsor:
Agency:
Tianjin Hemay Pharmaceutical Co., Ltd
Agency class:
Industry
Source:
Ganzhou Hemay Pharmaceutical Co., Ltd
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06313983