A Study of GFH009 in Combination With Zanubrutinib in Subjects With Relapsed or Refractory DLBCL

Trial Title: A Study of GFH009 in Combination With Zanubrutinib in Subjects With Relapsed or Refractory DLBCL

NCT ID: NCT06375733

Condition: Large B-cell Lymphoma

Conditions: Official terms:
Lymphoma
Lymphoma, B-Cell
Zanubrutinib

Conditions: Keywords:
relapsed or refractory diffuse large B-cell lymphoma (DLBCL)

Study type: Interventional

Study phase: Phase 1/Phase 2

Overall status: Recruiting

Study design:

Allocation: Non-Randomized

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: GFH009
Description: administered as an IV infusion at the dose levels 75mg, 60mg, and/or 100mg QW.
Arm group label: Phase 1b:GFH009 & Zanubrutinib

Intervention type: Drug
Intervention name: Zanubrutinib
Description: administered at 160mg BID oral; 28-day a cycle until disease progresses.
Arm group label: Phase 1b:GFH009 & Zanubrutinib

Intervention type: Drug
Intervention name: GFH009
Description: the RP2D of GFH009 defined in the preliminary phase 1b trial with the same schedule as in the phase Ib.
Arm group label: Phase 2: GFH009 & Zanubrutinib

Intervention type: Drug
Intervention name: Zanubrutinib
Description: administered at 160mg BID oral; 28-day a cycle until disease progresses.
Arm group label: Phase 2: GFH009 & Zanubrutinib

Summary: This is a multicentre, open-label phase Ib/II study. The purpose of the study is to assess the safety and efficacy of GFH009 in combination with Zanubrutinib in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL)

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. Age ≥ 18 years old. 2. Relapsed or refractory diffuse large B-cell lymphoma (DLBCL), including: DLBCL, not specified (NOS), T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL), high-grade B-cell lymphoma, or large B-cell lymphoma transformed from indolent B-cell lymphoma (including but not limited to Richter syndrome, transformed follicular lymphoma, transformed MZL) (2016 WHO classification). 3. Relapse or refractory after receiving 2~4 systemic treatment regimens, at least one of which contains anthracyclines and Rituximab. 4. Must have a measurable lesion. 5. The patient is not suitable to receive stem cell transplantation judged by the investigator. 6. The Eastern Cooperative Oncology Group (ECOG) performance status score (PS) is 0~2. 7. Have adequate organ function, including: i. Hematopoietic function: absolute neutrophil count (ANC) ≥1.0×109/L, platelet count (PLT) ≥75×109/L and hemoglobin (Hgb) ≥ 80 g/L. ii. Liver function: total bilirubin ≤ 1.5 × upper limit of normal (ULN), Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 × ULN. iii. Renal function: Serum creatinine (Cr) ≤ 1.5 × ULN, or serum creatinine clearance ≥ 50 mL/min when Cr > 1.5× ULN. iv. Coagulation function: International normalized ratio (INR) and activated partial thromboplastin time (APTT) ≤ 1.5 × ULN. Exclusion Criteria: 1. Primary or secondary central nervous system (CNS) lymphoma. 2. Received chemotherapy, targeted therapy, endocrine therapy, immunotherapy, Chinese patent medicine with anti-tumor effect and other investigational drugs or device therapy within 28 days or 5 half-lives (whichever is shorter), or received therapeutic or palliative radiotherapy within 14 days, or received CAR-T therapy within 12 weeks prior to the administration of the study drugs. 3. Patients with primary resistance to CDK9 or BTK inhibitors. 4. Has a history of organ transplantation or allogeneic stem cell transplantation. Patients who have undergone autologous stem cell transplantation within 6 months. 5. Other malignancies within 2 years prior to study entry, excluding appropriately treated carcinoma in situ of the cervix, focal squamous cell carcinoma of the skin, basal cell carcinoma, prostate cancer not requiring treatment, ductal carcinoma in situ of the breast, and superficial non-muscle-invasive urothelial carcinoma. 6. Have significant diseases of the cardiovascular system or significant acute or chronic infection. History of stroke or intracranial hemorrhage within 6 months prior to enrollment. Presence of significant gastrointestinal disorders. Current clinically significant interstitial lung disease, radiation pneumonitis, or drug-associated pneumonia requiring treatment. Accompanied by other poorly controlled systemic diseases, such as hypertension, diabetes mellitus, etc. 7. Has a history of bleeding disorder or a history of spontaneous bleeding requiring blood transfusion or other medical intervention. Active bleeding within 2 months prior to the first dose. 8. Surgical procedures (excluding needle biopsies) that may affect the administration or study evaluation of this study within 28 days prior to the first dose. 9. Patients who have been treated with prednisone (or equivalent doses of glucocorticoids) at >20 mg/day for anti-tumor purposes within 7 days, or who require long-term use of glucocorticoids for non-anti-tumor therapy. 10. Ongoing medical treatment with a potent inhibitor or inducer of CYP3A is required.

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Guangxi Medical University Cancer Hospital&Guangxi Cancer Institute

Address:
City: Nanning
Country: China

Status: Recruiting

Contact:
Last name: Cen Hong

Facility:
Name: Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital

Address:
City: Zhengzhou
Country: China

Status: Recruiting

Contact:
Last name: Keshu Zhou

Start date: March 20, 2024

Completion date: December 31, 2026

Lead sponsor:
Agency: Zhejiang Genfleet Therapeutics Co., Ltd.
Agency class: Industry

Source: Genfleet Therapeutics (Shanghai) Inc.

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06375733