High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors

Trial Title: High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors

NCT ID: NCT06418789

Condition: Germ Cell Tumor

Conditions: Official terms:
Neoplasms, Germ Cell and Embryonal

Conditions: Keywords:
Germ Cell Tumor
Teratoma
Choriocarcinoma
Germinoma
Childhood Teratoma
Extragonadal Seminoma
Seminoma
Non-seminomatous Germ Cell Tumor
Yolk Sac Tumor
Mixed Germ Cell Tumor
Malignant Germ Cell Neoplasm

Study type: Interventional

Study phase: Phase 2

Overall status: Recruiting

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: High-dose chemotherapy (TI- 2 cycles, CE- 3 cycles )
Description: TI: Paclitaxel 200mg/m² on day 1, Ifosfamide 2000mg/m² daily from days 1 to 3 of 14-day cycle. G-CSF 10 micrograms/Kg SC daily day on days 6-14 day or until CD34 harvest. Leukapheresis will be performed starting on day 11 in case blood level of CD45+CD34+ above 20x10^6/L is achieved. CE: Carboplatin AUC=8 IV daily days -4 to -2, Etoposide 400mg/m^2 IV daily days -4 to -2, autlologous stemm cell transplantation >=2*10^6/Kg at day 0, GCSF support from day 4 until the recovery of neutrophils above 1*10^9/L. Patients will receive two cycles of TI followed by 3 cycles of CE in case at least 6*10^6 CD34+ stem cells will be harvested.
Arm group label: Group 1

Summary: This is a prospective, single-center, non-randomized phase II study. Patients with germ cell tumors of gonadal and extragonadal localization who have progressed after prior platinum-containing first-line chemotherapy will receive high-dose chemotherapy with TI (2 cycles) folollowed by high dose CE chemotherapy with autologous stem cell transplantation (3 cycles). The primary endpoint of the study is to evaluate the efficacy high-dose chemotherapy as second-line drug therapy for patients with advanced germ cell tumors.

Detailed description: Germ cell tumors are curable diseases. Only a small proportion of patients fail to be cured: those who experience a primary resistance to chemotherapy and those who relapsed after first line conventional dose cisplatin-based chemotherapy. Nowadays, there is heterogeneity of practice in salvage approaches. This includes conventional chemotherapy high dose chemotherapy with autologous stem cell transplant. Best choice of the therapy strategy is an unmet clinical need now. This is why this single-center, non-randomized phase II study will be conducted at the N.N. Petrov National Medical Research Center of Oncology. Patients with germ cell tumors of gonadal and extragonadal localization who have progressed after prior platinum-containing first-line chemotherapy will receive two cycles of high-dose TI (Paclitaxel 200mg/m² on day 1, Ifosfamide 2000mg/m² daily from days 1 to 3 of 14-day cycle. G-CSF 10 micrograms/Kg SC daily day on days 6-14 day or until CD34 harvest; leukapheresis will be performed starting on day 11 in case of CD45+CD34+ blood level above 20x10^6/L is achieved), followed by three cycles of high dose CE (Carboplatin AUC=8 IV daily days -4 to -2, Etoposide 400mg/m^2 IV daily days -4 to -2, autlologous stem cell transplantation at day 0, GCSF support from day 4.) The primary endpoint of the study is to evaluate the efficacy by measuring progression-free survival. The secondary endpoints of the trial are overall survival, response rate by RECIST, safety and prognostic factors analysis.

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. Patient is able to provide informed consent and sign approved consent forms to participate in the study. 2. Males ≥ 18 years of age at the time of signing the IC Form. 3. Histologically verified diagnosis of GO (seminomatous, non-seminomatous). 2. Any (gonadal and extragonadal (retroperitoneal, mediastinal, etc.)) localization of primary GO. 3. Progression after 3 or 4 cycles of platinum-containing first-line chemotherapy (ВЕР or EP). 4. Required Initial Laboratory Values: - Hemoglobin ≥ 90 g/L; - neutrophils ≥ 1.5 x 109/L; - platelets ≥ 75 x 109/L; - creatinine ≥ 1.5 x HGH (or CKF ≤ 60 mL/min); - ALT or AST ≥ 2.5 x HGN (5 x HGN for patients with liver metastases); - bilirubin ≥ 1.5 x IUH (except for patients with Gilbert syndrome, in whom total bilirubin levels should not exceed 50 μmol/L); - alkaline phosphatase ≥ 2.5 x IUH. 5. Absence of neurologic symptoms in the presence of CNS metastases (asymptomatic CNS metastases are acceptable). Exclusion Criteria: 1. Primary CS of the brain 2. Administration of ≥2 lines of prior drug therapy for disseminated GO. 3. Presence of active hepatitis B or hepatitis C, HIV infection, acute infectious disease, or activation of chronic infectious disease less than 28 days prior to study inclusion. 4. Conditions that limit the patient's ability to fulfill the requirements of the protocol (psychiatric disorders, drug or alcohol dependence).

Gender: Male

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: National Medical Research Center of Oncology named after N.N.Petrov Ministry of health of Russia

Address:
City: Saint Petersburg
Zip: 197758
Country: Russian Federation

Status: Recruiting

Contact:
Last name: Anna I Semenova, MD, PhD

Start date: March 1, 2024

Completion date: March 1, 2029

Lead sponsor:
Agency: N.N. Petrov National Medical Research Center of Oncology
Agency class: Other

Source: N.N. Petrov National Medical Research Center of Oncology

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06418789