Surufatinib Combined With Carboplatin/Paclitaxel and Surufatinib Combined With Olaparib as First-line and Maintenance Therapy for Newly Diagnosed High-risk Ovarian Cancer

Trial Title: Surufatinib Combined With Carboplatin/Paclitaxel and Surufatinib Combined With Olaparib as First-line and Maintenance Therapy for Newly Diagnosed High-risk Ovarian Cancer

NCT ID: NCT06437353

Condition: Ovarian Cancer

Conditions: Official terms:
Ovarian Neoplasms
Carcinoma, Ovarian Epithelial
Paclitaxel
Carboplatin

Conditions: Keywords:
Antiangiogenic

Study type: Interventional

Study phase: Phase 2

Overall status: Recruiting

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Paclitaxel
Description: First-line chemotherapy regimen: - Paclitaxel: 175 mg/m², intravenous infusion, on day 1. - Carboplatin: AUC 5, intravenous infusion, on day 1. - Surufatinib：250 mg once daily, taken continuously. Maintenance Therapy Regimen: - Surufatinib: 250 mg once daily, taken continuously. - Olaparib: 300 mg twice daily.
Arm group label: First-line and maintenance therapy regimen

Other name: Surufatinib

Other name: Carboplatin

Summary: The goal of this type of clinical trial study is to evaluate the safety and efficacy of Surufatinib combined with Carboplatin/Paclitaxel and Surufatinib combined with Olaparib as first-line and maintenance therapy for newly diagnosed high-risk ovarian cancer

Detailed description: Patients will have tests and exams to see if they are eligible for the clinical trial. First-line chemotherapy regimen: Paclitaxel/Carboplatin(repeat every 3 weeks, total of 6 cycles): - Paclitaxel: 175 mg/m², intravenous infusion, on day 1. - Carboplatin: AUC 5, intravenous infusion, on day 1. - For patients aged ≥70 years or those with comorbidities, the paclitaxel dose can be adjusted to 135 mg/m². Surufatinib(repeat every 3 weeks, total of 5 cycles): - Surufatinib is not used during the first postoperative cycle. - Starting from the second postoperative cycle, surufatinib is administered at a dose of 250 mg once daily, taken continuously. Maintenance Therapy Regimen: HRD-positive Patients: - Surufatinib: 250 mg once daily, taken continuously. - Olaparib: 300 mg twice daily, with doses taken 12 hours apart. Olaparib can be used for a maximum of 2 years. HRD-negative or HRD Status Unknown Patients: - Surufatinib: 250 mg once daily, taken continuously. Treatment continues until the patient experiences disease progression or meets other criteria for discontinuation of the study treatment as specified in the protocol.

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. Age: 18-75 years old (≥18, ≤75) 2. Patients with newly diagnosed FIGO stage III or IV high-grade serous ovarian cancer, high-grade endometrioid carcinoma, primary peritoneal cancer, and/or fallopian tube cancer with high-risk factors for recurrence. High-risk recurrence is defined as follows: - FIGO stage III with non-R0 resection; - FIGO stage IV; - Presence of ascites at initial diagnosis. 3. Patients who have undergone primary debulking surgery (PDS) for ovarian cancer. 4. ECOG performance status score: 0-2. 5. Postoperative administration time ≤12 weeks. 6. Expected survival of at least 3 months. 7. Major organ function within 7 days prior to treatment meets the following criteria: - Hemoglobin (HB) ≥90 g/L; - Absolute neutrophil count (ANC) ≥1.5×10⁹/L; - Platelets (PLT) ≥100×10⁹/L. 8. Biochemical parameters must meet the following standards: - Total bilirubin (TBIL) ≤1.5 times the upper limit of normal (ULN); - Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5×ULN, or ≤5×ULN if liver metastases are present; - Serum creatinine (Cr) ≤1.5×ULN or creatinine clearance (CCr) ≥60 ml/min. 9. Women of childbearing potential must use effective contraception. 10. Subjects must voluntarily join the study and sign the informed consent form (ICF). 11. Subjects are expected to have good compliance and the ability to follow up on efficacy and adverse reactions as required by the protocol. Exclusion Criteria: 1. Previous treatment with anti-angiogenic drugs such as apatinib, sorafenib, anlotinib, bevacizumab, or other anti-angiogenic therapies. 2. Pregnant or breastfeeding women. 3. Patients who have previously participated in other clinical trials that have not yet concluded. 4. Patients with evidence or history of significant bleeding tendencies or events within 3 months before enrollment (bleeding >30 mL, accompanied by hematemesis, melena, or hematochezia), hemoptysis (≥5 mL of fresh blood within 4 weeks), or thromboembolic events (including stroke and/or transient ischemic attack) within 12 months. 5. Patients with uncontrolled hypertension (systolic blood pressure ≥150 mmHg or diastolic blood pressure ≥100 mmHg). 6. Patients with grade I or higher myocardial ischemia or infarction, arrhythmias (including QTc ≥480 ms), or ≥ grade 2 congestive heart failure (New York Heart Association (NYHA) classification). 7. Patients with active or uncontrolled severe infections (≥CTC AE grade 2). 8. Patients with renal failure requiring hemodialysis or peritoneal dialysis. 9. Patients with a history of immunodeficiency, including HIV positivity or other acquired or congenital immunodeficiency diseases, or those with a history of organ transplantation. 10. Patients with persistent proteinuria (≥++) on two consecutive urine tests, and confirmed 24-hour urine protein >1.0 g. 11. Patients with psychiatric disorders, including epilepsy, dementia, severe depression, mania, etc. 12. Patients with any signs or history of bleeding disorders, regardless of severity; patients who experienced any bleeding or hemorrhagic event ≥CTCAE grade 3 within 4 weeks before enrollment; patients with unhealed wounds, ulcers, or fractures. 13. Patients who had arterial or venous thrombotic events, such as cerebrovascular accidents (including transient ischemic attacks), deep vein thrombosis, or pulmonary embolism, within the past 6 months. 14. Patients with symptomatic brain metastases or those whose symptoms have been controlled for less than 2 months. 15. Patients with a history of substance abuse that cannot be relinquished or those with psychiatric disorders. 16. Patients with difficulty swallowing or known absorption disorders affecting drug intake. 17. Patients allergic to treatment drugs sorafenib or paclitaxel/carboplatin. 18. Any other condition that the researcher deems unsuitable for enrollment.

Gender: Female

Minimum age: 18 Years

Maximum age: 75 Years

Healthy volunteers: No

Locations:

Facility:
Name: Anhui Cancer Hospital

Address:
City: Hefei
Zip: 230001
Country: China

Status: Recruiting

Contact:
Last name: Bai-Rong Xia, MD

Phone: 18604516165
Email: xiabairong9999@126.com

Start date: May 25, 2024

Completion date: October 30, 2027

Lead sponsor:
Agency: Anhui Provincial Cancer Hospital
Agency class: Other

Collaborator:
Agency: Hutchison Medipharma Limited
Agency class: Industry

Source: Anhui Provincial Cancer Hospital

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06437353