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Trial Title:
Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement: Beyond the Frequency Range
NCT ID:
NCT06438419
Condition:
Parkinson Disease
Hyperkinesis
Hypokinesia
Conditions: Official terms:
Ganglion Cysts
Parkinson Disease
Parkinsonian Disorders
Hypokinesia
Hyperkinesis
Conditions: Keywords:
Parkinson disease
hypokinetic disorders
dyskinesia
networks
basal ganglia
Study type:
Interventional
Study phase:
N/A
Overall status:
Not yet recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Basic Science
Masking:
None (Open Label)
Intervention:
Intervention type:
Other
Intervention name:
Electrophysiological recordings
Description:
Electrophysiological recordings will be made during a motor task in four different
conditions:
1. without pharmacological treatment and without stimulation (Off condition),
2. without pharmacological treatment and during stimulation (DBS condition),
3. during pharmacological treatment and without stimulation (DOPA condition),
4. during pharmacological treatment and stimulation (DOPA+DBS condition).
Arm group label:
Recruited patient
Summary:
Expression of hypokinetic and hyperkinetic motor symptoms in Parkinson's disease (PD) is
associated with pathological synchronous oscillations of neuronal activity (local field
potential/LFP) in the cortico-subcortical network with a wide frequency range. In the
present project, we propose to study cortico-subcortical oscillations and their
synchronization in patients operated for PD (subthalamic deep brain stimulation
(STN-DBS)) during distinct pharmacological and stimulation conditions (hypokinetic and
hyperkinetic), using a simple motor task.
Detailed description:
To define the link between the characteristics of neuronal oscillations (frequency,
amplitude, phase relationship) within the cortico-subcortical network and the movement,
we designed a simple motor task of gripping/pulling a lever. The LFPs will be collected
at the cortical and subcortical levels (STN) during the motor task using a
high-resolution EEG (HR-EEG) and the Percept™ system (Medtronic). Recordings will be
realized in four conditions: without pharmacological treatment and without stimulation
(Off condition), without pharmacological treatment and during stimulation (DBS
condition), during pharmacological treatment and without stimulation (DOPA condition) and
during pharmacological treatment and stimulation (DOPA+DBS condition).
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Male or Female
- 18 to 75 years-old
- With idiopathic Parkinson's disease
- Having a STN-DBS with a PERCEPT™ for less than a year or being candidate for STN-DBS
with the PERCEPT™ device (first-implantation)
- Able to perform the simple motor task
- Patients covered by a health insurance scheme
- Giving free, informed, written consent signed by the participant and the
investigator.
Exclusion Criteria:
- Be incapable of giving consent personally.
- Be subject to a legal protection measure (curatorship, guardianship) or be placed
under judicial protection.
- Being pregnant or breastfeeding
- Present a serious and/or decompensated somatic or psychiatric illness.
Gender:
All
Minimum age:
18 Years
Maximum age:
75 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Bordeaux University Hospital
Address:
City:
Bordeaux
Country:
France
Contact:
Last name:
Dominique Guehl, Pr
Email:
dominique.guehl@chu-bordeaux.fr
Contact backup:
Last name:
Claire BRANDET
Email:
claire.brandet@chu-bordeaux.fr
Start date:
June 2024
Completion date:
June 2026
Lead sponsor:
Agency:
University Hospital, Bordeaux
Agency class:
Other
Collaborator:
Agency:
Université de Bordeaux, IMN, UMR CNRS 5293
Agency class:
Other
Source:
University Hospital, Bordeaux
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06438419
