Trial Title:
Phase II Trial of Ubamatamab Alone or in Combination With Cemiplimab in MUC16-Expressing SMARCB1-Deficient Malignancies
NCT ID:
NCT06444880
Condition:
SMARCB1-Deficient Malignancies
Conditions: Official terms:
Neoplasms
Cemiplimab
Study type:
Interventional
Study phase:
Phase 2
Overall status:
Recruiting
Study design:
Allocation:
Non-Randomized
Intervention model:
Single Group Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
Ubamatamab
Description:
Given by IV
Arm group label:
Stage 2
Arm group label:
Stage I
Intervention type:
Drug
Intervention name:
Cemiplimab
Description:
Given by IV
Arm group label:
Stage 2
Summary:
To find out if ubamatamab, given by itself or in combination with cemiplimab, can help to
control the disease in participants with renal medullary carcinoma (RMC) and epithelioid
sarcoma (ES).
Detailed description:
Primary Objectives • To determine the objective response rate (ORR) and disease control
rate (DCR), per RECIST 1.1, of ubamatamab alone and in combination with cemiplimab in
patients with locally advanced or metastatic MUC16-expressing SMARCB1-deficient
malignancies, RMC or ES, who have progressed on at least one prior line of therapy.
Secondary Objectives
• To determine the efficacy and safety of ubamatamab alone or in combination with
cemiplimab in participants with locally advanced or metastatic MUC16-expressing
SMARCB1-deficient malignancies such as RMC or ES who have progressed on at least one
prior line of therapy. Efficacy will be measured by overall survival (OS),
progression-free survival (PFS), and duration of response (DOR).
Exploratory Objectives
- To determine the objective response rate (ORR) and disease control rate (DCR), per
RECIST 1.1, of the overall strategy of ubamatamab alone followed by combination with
cemiplimab in participants with locally advanced or metastatic MUC16-expressing
SMARCB1-deficient malignancies, RMC or ES, who have progressed on at least one prior
line of therapy.
- To evaluate potential biomarkers, such as serum CA-125 and tumor tissue MUC16
expression levels for participant stratification, and to determine via the molecular
profiling of biopsy and blood specimens, the mechanisms of resistance to ubamatamab
alone or in combination with cemiplimab.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
1. Participants with locally advanced or metastatic RMC (RMC cohort) or ES (ES cohort)
histologically confirmed by expert pathology review and loss of SMARCB1 staining by
IHC. Participants with advanced or metastatic unclassified renal cell carcinoma with
medullary phenotype (a rare SMARCB1 negative RMC variant occurring in individuals
without sickle hemoglobinopathies) are also eligible for the RMC cohort.
2. Eligible participants should either demonstrate serum CA-125 levels ≥ 70 units/ml
during screening or positive H score of >25 for MUC16 (CA-125) by IHC in tumor
tissues collected within 12 months from screening as noted in participant EMR:
1. The H score is calculated using the standard formula commonly used in IHC: H
score = [(0 x % negative cells) + (1 x % weak positive cells) + (2 x % moderate
positive cells) + (3 x % strong positive cells). For instance, if 50% of tumor
cells show weak staining, 30% of tumor cells show moderate staining, and 20% of
cells show strong staining, the H-score would be:
(50×1)+(30×2)+(20×3)=50+60+60=170.
2. If serum CA-125 ≥ 70 units/ml then participants will be enrolled without delay.
IHC for MUC16 will be used as a correlative biomarker but not for trial
eligibility.
3. If serum CA-125 < 70 units/ml then for trial eligibility, MUC16 expression
should be checked by IHC in tumor tissues collected within 12 months from
screening:
i. If H score is < 25 then the patient will not be eligible for the trial ii. If H
score ≥ 25 then the patient will be eligible for the trial
3. Participants will be eligible in the RMC cohort regardless of whether they have had
prior nephrectomy or still have their primary tumor in-situ.
4. Participants must have at least one measurable site of disease, defined as a lesion
that can be accurately measured in at least one dimension (longest diameter to be
recorded) and measures ≥ 15 mm with conventional techniques or ≥ 10 mm with more
sensitive techniques such as MRI or CT scan. If the patient has had previous
radiation to the marker lesion(s), there must be evidence of progression since the
radiation.
5. Participants must have progressed on at least one line of prior therapy.
6. There must be evidence of progression on or after last treatment regimen received.
7. ECOG performance status 0-1
a. NOTE: If participant is unable to walk due to paralysis, but is mobile in a
wheelchair, participant is considered to be ambulatory for the purpose of assessing
their performance status.
8. Age (at the time of consent/assent): ≥ 18 years
a. RMC is the third most common renal cell carcinoma in children and young adults in
the United States21 and while we will initially enroll participants aged ≥18 years
old, we will in coordination with Regeneron consider allowing pediatric participants
≥12 years old if no trial limiting toxicities (TOX), as defined in Section 9.1.2.,
after the interim analysis of the first 10 participants enrolled and based on the
accumulated pharmacokinetic / pharmacodynamic data of ubamatamab in this population
at that time. If these criteria are fulfilled, then adolescent participants age 12
years and older will be allowed with signed assent and parental consent according to
institutional guidelines and requirements, as long as their weight is >40 kg given
that this is the lower weight limit for which safety following ubamatamab with or
without cemiplimab exposure has been ascertained.
9. Consent to MD Anderson companion laboratory protocol 2014-0938
10. Participants must have adequate organ and marrow function as defined below:
Hemoglobina ≥ 9 g/dl (treatment allowed) Absolute neutrophil countb ≥ 1,000/µL
Platelets ≥ 75,000/µL Total bilirubin ≤ 1.5 mg/dl AST(SGOT) or ALT (SGPT) ≤ 2.5 X
institutional ULN, except in known hepatic metastasis, wherein may be ≤ 5 x ULN
Serum Creatininec ≤ 1.5 x ULN by gender (as long as patient does not require
dialysis)
a May receive transfusion within the screening period b Without growth factor
support (filgrastim or pegfilgrastim) for at least 14 days c If creatinine is not
<1.5×ULN, then calculate by Cockcroft-Gault methods or local institutional standard
and CrCl must be >30 mL/kg/1.73 m2
11. Participants with controlled brain metastases are allowed on protocol if the brain
metastases were surgically resected or treated with radiosurgery or Gamma knife,
without recurrence or edema for 1 month (4 weeks). Participants actively requiring
glucocorticoids for uncontrolled brain or leptomeningeal metastases are not
eligible.
12. Women of childbearing potential (WOCBP) must have a negative serum or urine
pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 24
hours prior to the start of the study drug.
13. Women must not be breastfeeding.
14. WOCBP must agree to follow instructions for method(s) of contraception from the time
of registration for treatment for the duration of treatment with study drug (s) plus
5 half-lives of study drug (s) plus 30 days (duration of ovulatory cycle) for a
total of 5 months post treatment completion. Men must agree to effective
contraception from the time of registration for treatment to 7 months post last
protocol treatment.
Investigators shall counsel WOCBP and male participants who are sexually active with
WOCBP on the importance of pregnancy prevention and the implications of an
unexpected pregnancy Investigators shall advise WOCBP and male participants who are
sexually active with WOCBP on the use of highly effective methods of contraception.
Highly effective methods of contraception have a failure rate of < 1% per year when
used consistently and correctly.
Approved methods of birth control are as follows: Hormonal contraception (i.e. birth
control pills, injection, implant, transdermal patch, vaginal ring), Intrauterine
device (IUD), Tubal Ligation or hysterectomy, Patient/Partner post vasectomy,
Implantable or injectable contraceptives, and condoms plus spermicide. Not engaging
in sexual activity for the total duration of the trial and the drug washout period
is an acceptable practice; however periodic abstinence, the rhythm method, and the
withdrawal method are not acceptable methods of birth control. Should a woman become
pregnant or suspect she is pregnant while she or her partner is participating in
this study, she should inform her treating physician immediately.
Men treated or enrolled on this protocol must also agree to use adequate
contraception prior to the study, for the duration of study participation, and 7
months after completion of ubamatamab/cemiplimab administration.
The effects of ubamatamab/cemiplimab on the developing human fetus are unknown. For
this reason and because immunotherapy agents as well as other therapeutic agents
used in this trial are known to be teratogenic, women of child-bearing potential and
men must agree to use adequate contraception (hormonal or barrier method of birth
control; abstinence) prior to study entry and for the duration of study
participation. (Refer to Pregnancy Assessment Policy MD Anderson Institutional
Policy # CLN1114). This includes all female participants, between the onset of
menses (as early as 8 years of age) and 55 years unless the patient presents with an
applicable exclusionary factor which may be one of the following:
- Postmenopausal (no menses in greater than or equal to 12 consecutive months).
- History of hysterectomy or bilateral salpingo-oophorectomy.
- Ovarian failure (Follicle Stimulating Hormone and Estradiol in menopausal
range, who have received Whole Pelvic Radiation Therapy).
- History of bilateral tubal ligation or another surgical sterilization
procedure.
15. Ability to understand and the willingness to sign a written informed consent
document.
Exclusion Criteria:
1. Participants must not have any other malignancies within the past 2 years except for
in situ carcinoma of any site, or adequately treated (without recurrence
post-resection or post-radiotherapy) carcinoma of the cervix or basal or squamous
cell carcinomas of the skin, ductal carcinoma in situ of the breast or low-risk
early stage prostate adenocarcinoma with negligible risk of metastasis or death
2. Participants previously treated with T-cell-redirecting bispecific antibodies or
MUC16-targeted therapies (including vaccines) are excluded. Participants who
received CAR-T therapies within 30 days of first dose of study drug are also
excluded. However, participants previously treated with immune checkpoint therapies
such as anti-PD1, anti-PD-L1, anti-CTLA-4, or anti-LAG-3 immune checkpoint
inhibitors are eligible, as long as they have been off these therapies for at least
60 days (~3 half-lives) prior to initiation of study treatment with ubamatamab.
3. Participants currently receiving anticancer therapies or who have received
anticancer therapies (including chemotherapy and targeted therapies such as
tazemetostat) within 2 weeks (14 days) prior to study Day 1 are excluded.
Participants who have completed palliative radiation therapy more than 14 days prior
to the first dose of the combination immunotherapy are eligible.
4. Participants with persistent grade ≥2 adverse events from prior systemic therapies
that would confound timely detection of immune-related adverse events due to
ubamatamab and/or cemiplimab or otherwise hinder patient participation in the
clinical trial.
5. Participants, who have had a major surgery or significant traumatic injury (injury
requiring > 4 weeks (28 days) to heal) within 4 weeks (28 days) of start of study
drug, participants who have not recovered from the side effects of any major surgery
(defined as requiring general anesthesia).
6. Participants who have organ allografts.
7. Known or suspected autoimmune disease. Participants with a history of inflammatory
bowel disease (including Crohn's disease and ulcerative colitis) and autoimmune
disorders such as rheumatoid arthritis, systemic progressive sclerosis
[scleroderma], Systemic Lupus Erythematosus or autoimmune vasculitis [e.g.,
Wegener's Granulomatosis] are excluded from this study. Participants with a history
of Hashimoto's thyroiditis only requiring hormone replacement, Type I diabetes, or
psoriasis not requiring systemic treatment, or conditions not expected to recur in
the absence of an external trigger are allowed to participate.
8. Uncontrolled infection with human immunodeficiency virus, hepatitis B or hepatitis C
infection; or diagnosis of immunodeficiency.
1. Participants with HIV who have controlled infection (undetectable viral load
with the exception of clinically insignificant blips and CD4 count above 350
either spontaneously or on a stable antiviral regimen) are permitted.
2. Participants with hepatitis B surface antigen positive (HepBsAg+) who have
controlled infection (serum hepatitis B virus DNA PCR that is below the limit
of detection AND receiving antiviral therapy for hepatitis B) are permitted.
3. Participants with HBsAg negative but total HBV core antibody positive (HBc Ab+)
are permitted with the following requirements: Serum HBV DNA PCR should be
tested and if it is above the limit of detection at screening then antiviral
therapy for HBV must be initiated prior to study entry. If serum HBV DNA PCR is
below the limit of detection periodic monitoring of HBsAg must be performed
every 12 months +/- 3 months.
4. Participants who are Hepatitis C virus antibody positive (HCV Ab +) who have
controlled infection (undetectable HCV RNA by PCR either spontaneously or in
response to a successful prior course of anti-HCV therapy) are permitted.
9. Any underlying medical condition, which in the opinion of the Investigator, will
make the administration of study drug hazardous or obscure the interpretation of
adverse events, such as a condition associated with frequent diarrhea, uncontrolled
nausea or vomiting. Patients with active COVID-19 disease as indicated by a positive
polymerase reaction (PCR) test are excluded. Participants with previous COVID-19
disease are allowed if ≥30 days from last positive test, and COVID-19 symptoms have
resolved and/or PCR test is now negative.
10. Participants must not be scheduled to receive another experimental drug while on
this study.
11. Participants who are on high dose steroid (e.g., > 10mg prednisone daily or
equivalent) or other more potent immune suppression medications (e.g., infliximab).
Topical, inhaled, intra-articular, ocular, or intranasal corticosteroids (with
minimal systemic absorption) are allowed. A brief course (<48 hours) of systemic
corticosteroids for prophylaxis (eg, from contrast dye allergy) is permitted.
Physiological corticosteroid replacement therapy for adrenal insufficiency (up to
hydrocortisone 30 mg / daily or equivalent) is also permitted.
12. Left ventricular ejection fraction (LVEF) assessment with documented LVEF < 50% by
transthoracic echocardiogram (TTE) within 6 months prior to start of study
treatment. In cases of LVEF 45-50% in absence of clinical symptoms, after review and
clearance by cardiologist, the patient may be enrolled.
13. Active myocarditis, regardless of etiology.
14. Moderate to large pericardial effusion (eg, > approximately 100 mL) as measured by
echocardiogram at baseline. Multigated acquisition (MUGA) is not sufficient for
evaluating pericardial effusion.
15. Has a history of any clinically significant arrhythmia including atrial fibrillation
or implantation of a pacemaker or defibrillator.
16. Participants who have any severe and/or uncontrolled medical conditions or other
conditions that could affect their participation in the study such as:
1. Symptomatic congestive heart failure of New York heart Association Class III or
IV
2. Unstable angina pectoris, symptomatic congestive heart failure, myocardial
infarction within 6 months of start of study drug, serious uncontrolled cardiac
arrhythmia or any other clinically significant cardiac disease
3. Systemic fungal, bacterial, viral, or other infection that is not controlled
(defined as exhibiting ongoing signs/symptoms related to the infection and
without improvement) despite appropriate antibiotics or other treatment.
4. Participants with a history of major psychiatric illness judged unable to fully
understand the investigational nature of the study and the risks associated
with the therapy.
17. Participants must not have history of other diseases, metabolic dysfunction,
physical examination finding, or clinical laboratory finding giving reasonable
suspicion of a disease or condition that contraindicates the use of ubamatamab or
cemiplimab or that might affect the interpretation of the results of the study or
render the participant at high risk from treatment complications.
18. Participants should not receive immunization with attenuated live vaccines within 30
days of planned start of study medication.
a. Note: Seasonal influenza vaccines for injection are generally inactivated flu
vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist®)
are live attenuated vaccines, and are not allowed.
19. Female participants who are pregnant or breast feeding, or adults of reproductive
potential who are not willing to use effective birth control methods as defined
above.
20. Any participants who cannot be compliant with the appointments required in this
protocol must not be enrolled in this study.
21. History of allergic reactions attributed to compounds of similar chemical or
biologic composition to ubamatamab or cemiplimab.
22. Participants with psychiatric illness/social situations that would limit compliance
with study requirements.
Gender:
All
Minimum age:
12 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
MD Anderson Cancer Center
Address:
City:
Houston
Zip:
77030
Country:
United States
Status:
Recruiting
Contact:
Last name:
Pavlos Msaouel, MD,PHD,PHD
Phone:
713-563-4585
Email:
pmsaouel@mdanderson.org
Investigator:
Last name:
Pavlos Msaouel, MD,PHD,PHD
Email:
Principal Investigator
Start date:
October 9, 2024
Completion date:
July 31, 2028
Lead sponsor:
Agency:
M.D. Anderson Cancer Center
Agency class:
Other
Collaborator:
Agency:
Regeneron Pharmaceuticals
Agency class:
Industry
Source:
M.D. Anderson Cancer Center
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06444880
http://www.mdanderson.org
