A Clinical Study of YL205 in Patients With Advanced Solid Tumors

Trial Title: A Clinical Study of YL205 in Patients With Advanced Solid Tumors

NCT ID: NCT06459973

Condition: Advanced Solid Tumors

Conditions: Official terms:
Neoplasms

Study type: Interventional

Study phase: Phase 1/Phase 2

Overall status: Recruiting

Study design:

Allocation: Non-Randomized

Intervention model: Sequential Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: intravenous (IV) infusion
Description: YL205 is provided in the form of lyophilized powder under a strength of 160 mg/vial. Each vial should be reconstituted to 20 mg/mL. Prior to IV infusionSubjects will be treated with YL205 via intravenous (IV) infusion, once every 3 weeks (Q3W) as a treatment cycle
Arm group label: Phase II: Cohort expansion portion
Arm group label: Phase Ia: Dose escalation portion
Arm group label: Phase Ib: Dose expansion portion

Summary: This study is a multicenter, open-label, phase I/II study of YL205 in China to evaluate the safety, tolerability, PK characteristics and preliminary efficacy of YL205 in the following selected patients with advanced solid tumors.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - 1) Subjects who are informed of relevant information of the study prior to initiation of the study and voluntarily sign and date on the informed consent form (ICF). 2) Age ≥18 years. 3) Be willing to follow and be able to complete all the study procedures. 4) Body mass index (BMI) within the range of 18 to 32 kg/m2, and body weight ≥45kg for female subjects. 5） Patients with histologically or cytologically confirmed locally advanced or metastatic ovarian cancer (OC), non-squamous non-small cell lung cancer (NSQ NSCLC), renal cell carcinoma (RCC), endometrial cancer (EC), or other Napi2b-overexpressing tumors。 6) Patients with positive Napi2b test results at the central laboratory. 9) At least one radiologically evaluable lesion for subjects in Part 1; At least one measurable extracranial lesion (non-radiation fields) for subjects in Part 2 and Part 3. 10) Expected survival ≥3 months. 11) Female subjects of childbearing potential must agree to take effective contraceptive measures and must not undergo egg donation or egg retrieval for their own use from screening throughout the study period and for at least 6 months after the last dose of the investigational drug. Male subjects must agree to take effective contraceptive measures and must not undergo sperm cryopreservation or sperm donation from screening throughout the study period and for at least 6 months after the last dose of the investigational drug. 12) subjects must provide tumor samples. 13) Subjects who are capable of and willing to comply with the visits and procedures stipulated in the study protocol. Exclusion Criteria: - 1) Subjects with a treatment history with drugs targeting Napi2b. 2) Subjects with a history of intolerance to topoisomerase I inhibitors or ADC therapy. 3) Subjects who are participating in another clinical study, with the exception an of observational (non-interventional) clinical study or the follow-up period of an interventional study. 4) Subjects with an insufficient washout period from the previous anti-tumor therapy to the first dose. 5) Subjects who received radiotherapy, including palliative stereotactic radiotherapy on the abdomen, within 4 weeks prior to the first dose. 6) Subjects who received major surgery within 4 weeks prior to the first dose or those who plan to receive major surgery during the study. 7) Subjects who received allogeneic bone marrow transplantation or solid organ transplantation. 8) Subjects who received systemic steroids or other immunosuppressive treatment within 2 weeks prior to the first dose of the investigational drug. 9) Subjects who received any live vaccine within 4 weeks prior to the first dose or those who plan to receive live vaccines during the study. 10) Subjects with a medical history of leptomeningeal carcinoma or cancerous meningitis. 11) Subjects with brain metastasis or spinal cord compression. 12) Subjects with uncontrolled or clinically significant cardiovascular and cerebrovascular diseases. 13) Subjects who were diagnosed with Gilbert's syndrome. 14) Subjects with significantly symptomatic or unstable effusion in the third space requiring repeated drainage. 15) Subjects with medical history of gastrointestinal perforation and/or fistula within 6 months prior to the first dose, or active gastric ulcers, duodenal ulcer, colitis ulcerative, or other gastrointestinal disorders that may cause hemorrhage or perforation in the opinion of the investigator. 16) Subjects with serious infection (Grade ≥3 as per NCI CTCAE v5.0) prior to the first dose. 17) Subjects with human immunodeficiency virus (HIV), active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection; subjects with positive syphilis antibody and a positive titer result. 18) Subjects with unresolved toxicity caused by previous anti-tumor therapy. 20) Subjects with a history of serious allergic reactions to drugs, inactive ingredients in drug products, or other monoclonal antibodies. 21) Female subjects who are pregnant as confirmed by a pregnancy test within 3 days prior to the first dose, or lactating women. 22) Subjects who have any diseases, medical conditions, organ system dysfunction, or social conditions. 23) Subjects with multiple primary malignancies within 5 years prior to the signing of the ICF, except for fully resected non-melanoma skin cancer, radically treated carcinoma in situ, or other radically treated solid tumors.

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Jilin Provincial Cancer Hospital

Address:
City: Changchun
Country: China

Status: Recruiting

Contact:
Last name: Coordinator Clinical operation director

Phone: 0512-62858368
Email: RA@medilinkthera.com

Start date: June 4, 2024

Completion date: July 31, 2030

Lead sponsor:
Agency: MediLink Therapeutics (Suzhou) Co., Ltd.
Agency class: Industry

Source: MediLink Therapeutics (Suzhou) Co., Ltd.

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06459973