Zanubrutinib and G-CHOP in Untreated Intermediate-high Risk Follicular Lymphoma

Trial Title: Zanubrutinib and G-CHOP in Untreated Intermediate-high Risk Follicular Lymphoma

NCT ID: NCT06474481

Condition: FL

Conditions: Official terms:
Lymphoma
Lymphoma, Follicular
Prednisone
Cyclophosphamide
Doxorubicin
Vincristine
Obinutuzumab
Zanubrutinib

Conditions: Keywords:
Zanubrutinib
Intermediate-high risk Follicular Lymphoma
G-CHOP

Study type: Interventional

Study phase: Phase 2

Overall status: Not yet recruiting

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Zanubrutinib
Description: Zanubrutinib, 160mg PO BID.on days 1-28 Induction treatment: 4-6cycles ; Maintenance: 1 year;
Arm group label: Treatment arm

Intervention type: Drug
Intervention name: Obinutuzumab
Description: Induction treatment: Obinutuzumab (G), 1000mg, IV, D1/8/15 (C1), D1 (C2-4/6); for 4-6 cycles, 1 cycle = 28 days Maintenance: Obinutuzumab (G), 1000mg, IV, every 2 months for 1 year;
Arm group label: Treatment arm

Intervention type: Drug
Intervention name: Prednisone
Description: Prednisone (P), 100 mg, PO, D2-6；for 4-6 cycles for CHOP treatment , 1 cycle = 28 days
Arm group label: Treatment arm

Intervention type: Drug
Intervention name: Cyclophosphamide
Description: Cyclophosphamide (C), 750 mg/m2, IV, D2; for 4-6 cycles for CHOP treatment , 1 cycle = 28 days
Arm group label: Treatment arm

Intervention type: Drug
Intervention name: Vincristine
Description: Vincristine (O), 1.4 mg/m2 (maximum 2 mg), IV, D2; for 4-6 cycles for CHOP treatment , 1 cycle = 28 days
Arm group label: Treatment arm

Intervention type: Drug
Intervention name: Doxorubicin
Description: Doxorubicin (H), 50 mg/m2, IV, D2; for 4-6 cycles for CHOP treatment ，1 cycle = 28 days
Arm group label: Treatment arm

Summary: :This is a an open-label, single-arm study to evaluate the efficacy and safety of zanubrutinib and G-CHOP in untreated Intermediate-high risk Follicular Lymphoma patients.

Criteria for eligibility:
Criteria:
Inclusion criteria. 1. Histologically confirmed CD20 positive (+) follicular lymphoma, grade 1, 2, or 3a 2. Have had no prior systemic treatment for lymphoma 3. Meeting Groupe d'Etude des Lymphomes Folliculaires (GELF) criteria for initiation of treatment 4. 18-75 years old. 5. ECOG Performance Status of 0-2 within 10 days prior to registration. 6. Stage II, III, or IV by Ann Arbor staging system. 7. defined as Intermediate-high risk by the follicular lymphoma international prognostic index (FLIPI) 1 or FLIPI 2. 8. Demonstrate adequate organ function as defined below; all screening labs to be obtained within 28 days prior to registration. - Hematological: WBC≥3.5×109/L, Platelets ≥ 75×109/L,Absolute Neutrophil Count (ANC) ≥ 1.0×109/L，Hemoglobin (Hgb) ≥ 80 g/L - Renal:Calculated creatinine clearance ≥ 50 mL/min - Hepatic:Bilirubin ≤ 1.5 × upper limit of normal (ULN), AST/ALT ≤ 2.5×ULN 9. Females of childbearing potential must be willing to abstain from vaginal intercourse or use an effective method(s) of contraception from the time of informed consent, during the study and for 6 months after the last dose of study drug(s). Males able to father a child must be willing to abstain from vaginal intercourse or to use an effective method(s) of contraception from initiation of treatment, during the study and for 3 months after the last dose of study drug(s). See the protocol. 10. Life expectancy ≥6 months 11. Sign (or their legally-acceptable representatives must sign) an informed consent document indicating that they understand the purpose of and procedures required for the study, including biomarkers, and are willing to participate in the study Exclusion criteria: 1. Known active central nervous system lymphoma or leptomeningeal disease 2. Evidence of diffuse large B-cell transformation 3. Grade 3b FL 4. Concurrent malignancy or malignancy within the last 3 years (except for ductal breast cancer in situ, non-melanoma skin cancer, prostate cancer not requiring treatment, and cervical carcinoma in situ) whose natural history or treatment has the potential to interfere with the safety or efficacy assessment of the investigational regimen are not eligible for this trial 5. Known history of human immunodeficiency virus (HIV), or active hepatitis C Virus, or active hepatitis B Virus infection, or any uncontrolled active significant infection, including suspected or confirmed John Cunningham (JC) virus infection 6. Clinically significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of screening, or any class 3 (moderate) or class 4 (severe) cardiac disease as defined by the New York Heart Association functional classification. Or left ventricular ejection fraction <50%; 7. Neuropathy ≥grade 2 8. Known history of human immunodeficiency virus (HIV), or active hepatitis C Virus, or active hepatitis B Virus infection, or any uncontrolled active significant infection 9. Known pneumonia associated with idiopathic pulmonary fibrosis, machine (for example, occlusive bronchiolitis), history of drug induced pneumonia, or screening during the chest computed tomography (CT) showed active pneumonia 10. Have serious neurological or psychiatric history, can't normal study, including dementia, epilepsy, severe depression and mania 11. Patients who were deemed by the investigator to be ineligible for enrollment

Gender: All

Minimum age: 18 Years

Maximum age: 75 Years

Healthy volunteers: No

Start date: July 2024

Completion date: December 2029

Lead sponsor:
Agency: Tianjin Medical University Cancer Institute and Hospital
Agency class: Other

Source: Tianjin Medical University Cancer Institute and Hospital

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06474481