Trial Title:
A Prospective Cohort Study of Neoadjuvant Chemotherapy Plus Sintillumab in the Treatment of Resectable NSCLC
NCT ID:
NCT06485557
Condition:
Resectable Non-small Cell Lung Cancer
Conditions: Official terms:
Carcinoma, Non-Small-Cell Lung
Conditions: Keywords:
NSCLC
Neoadjuvant
Sintillumab
Study type:
Interventional
Study phase:
Phase 3
Overall status:
Not yet recruiting
Study design:
Allocation:
Randomized
Intervention model:
Parallel Assignment
Intervention model description:
A Prospective Cohort Study
Primary purpose:
Treatment
Masking:
Triple (Participant, Care Provider, Investigator)
Intervention:
Intervention type:
Drug
Intervention name:
sintilimab plus platinum-based chemotherapy
Description:
The subjects in group A will receive 3 cycles of sintilimab plus platinum-based
chemotherapy
Arm group label:
group A
Other name:
Group A
Intervention type:
Drug
Intervention name:
sintilimab plus platinum-based chemotherapy
Description:
The subjects in group B will receive 2 cycles of sintilimab plus platinum-based
chemotherapy plus 1 cycle of sintilimab
Arm group label:
group B
Other name:
Group B
Intervention type:
Drug
Intervention name:
sintilimab plus platinum-based chemotherapy
Description:
The subjects in group C will receive 1 cycle of sintilimab plus platinum-based
chemotherapy plus 2 cycles of sintilimab.
Arm group label:
group C
Other name:
Group C
Summary:
This study uses a prospective cohort design.Subjects are randomly divided into three
groups (A, B, C) before surgery. Group A gets 3 cycles of sintilimab + chemo, Group B
gets 2 cycles + 1 cycle, and Group C gets 1 cycle + 2 cycles.
Non-squamous NSCLC subjects receive pemetrexed/albumin paclitaxel + platinum, while
squamous NSCLC subjects get albumin paclitaxel + platinum.
Detailed description:
This study adopts a prospective cohort study design.The subjects will be randomly divided
into three groups according to the ratio of 1:1:1 prior to surgery: group A, group B and
group C. The subjects in group A will receive 3 cycles of sintilimab plus platinum-based
chemotherapy, group B will receive 2 cycles of sintilimab plus platinum-based
chemotherapy plus 1 cycle of sintilimab, and group C will receive 1 cycle of sintilimab
plus platinum-based chemotherapy plus 2 cycles of sintilimab. Non-squamous NSCLC subjects
will receive pemetrexed/albumin paclitaxel and platinum (cisplatin/carboplatin), and
squamous NSCLC subjects will receive albumin paclitaxel and platinum (cisplatin /
carboplatin).
Criteria for eligibility:
Criteria:
Inclusion Criteria:
1. Subjects must sign the written informed consent form (ICF), and be able to follow
the visits and relevant procedures specified in the protocol
2. Age ≥ 18 years
3. Cytologically or histologically confirmed primary NSCLC (including adenocarcinoma,
squamous cell carcinoma, adenosquamous carcinoma)
4. Subjects with Stage IIA (primary focus>4cm), IIIA or IIIB (resectable N2 only)
disease based on the 8th edition of the TNM staging classification for lung cancer
issued by the International Association for the Study of Lung Cancer and the
American Joint Committee on Cancer Classification (AJCC8), resectable N2 only refers
to non-massive (defined as short diameter less than 3cm), discrete or single station
N2 involvement.
5. No EGFR sensitive mutations and ALK rearrangements should be tested in non-squamous
non-small cell lung cancer, and will be not mandatory in squamous cell carcinoma
6. Deemed radically resectable with curative intent
7. Pulmonary function reached the standard of planned pneumonectomy ( FEV1 ≥ 50 %
predicted value, MVV ≥ 50 % predicted value ), and there was no surgical
contraindication
8. Enough tissue samples for PD-L1 detection (Number of slices ≥ 6)
9. At least one measurable lesion in line with RECIST V1.1
10. Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1
11. Have not received any prior systemic anti-tumor therapy or local radiotherapy for
NSCLC
12. Have adequate organ and bone marrow function, and the laboratory examination values
within 14 days prior to enrollment meet the following requirements (no blood
components, cell growth factors, albumin and other intravenous or subcutaneously
administered drugs to correct hematological or liver and kidney dysfunction were
allowed within the first 14 days of obtaining laboratory tests), as follows:
13. Hematological function was sufficient, defined as absolute neutrophil count ≥ 1.5 ×
109 / L, platelet count ≥ 100 × 109 / L, hemoglobin ≥ 100g / L;
14. Full liver function, defined as total bilirubin level ≤ 1.5 × ULN, AST and ALT level
≤ 2.5 × ULN, albumin (ALB) ≥ 35g / L;
15. Renal function was sufficient, serum creatinine (Scr) ≤ 1.5 × ULN, creatinine
clearance rate (CrCl) ≥ 60mL / min (calculated by Cockcroft / Gault formula) and
urine routine test results showed that urinary protein (UPRO) < 2 + or 24-hour
urinary protein < 1g;
16. The international normalized ratio (INR) ≤ 1.5 × ULN, and prothrombin time (PT) or
activated partial thromboplastin time (APTT) ≤ 1.5 × ULN within 7 days before
treatment;
17. For women of childbearing age, urine or serum pregnancy tests were negative for at
least seven days prior to the first study drug administration. If the urine
pregnancy test is positive, a blood pregnancy test is required;
18. If there is a risk of conception, male and female patients need to use
high-efficiency contraception (i.e., the method with an annual failure rate of less
than 1 %) and continue until at least 180 days after discontinuation of the trial;
Note: If abstinence is the normal lifestyle and preferred contraceptive method of
the subjects, abstinence can be accepted as a contraceptive method.
Exclusion Criteria:
1. Pathological examination showed that small cell carcinoma, neuroendocrine carcinoma,
sarcoma, lymphoepithelioma-like carcinoma, salivary gland tumor and mesenchymal
tumor components
2. Tumor invasion of the diaphragm, mediastinum, heart, pericardium, large blood
vessels (such as aorta), esophagus, vertebral body
3. pulmonary sulcus tumor
4. Contralateral lung nodules, it need biopsy if clinically suspected
5. Subjects with confirmed or suspected brain metastases
6. Currently participating in an interventional clinical study or treatment with
another study drug or study device within 4 weeks prior to randomization
7. Previous use of anti-PD-1, anti-PD-L1, anti-programmed death receptor ligand 2
(PD-L2) or anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) drugs or any
other drugs acting on T cell co-stimulation or immune checkpoint pathways (such as
OX40, CD137, etc.) and adoptive cellular immunotherapy
8. Received drugs with immunomodulatory effects (including thymosin, interferon,
interleukin) within the first 4 weeks of randomization
9. Received live attenuated vaccine within the first 4 weeks of randomization（Or plan
to receive live attenuated vaccine during the study period） Note: Acceptance of
inactivated vaccine for seasonal influenza is permitted; however, live attenuated
influenza vaccine is not allowed
10. Need long-term systemic use of corticosteroids，received any other form of
immunosuppressive therapy within 7 days before randomization Note: Nasal spray,
inhalation or other local glucocorticoids or physiological doses of systemic
glucocorticoids (≤ 10mg / day prednisone or equal doses of drugs) or for
pretreatment (such as prevention of contrast agent allergy) use is allowed
11. A history of non-infectious pneumonia requiring glucocorticoid therapy or current
interstitial lung disease (≥ grade 2) within the previous year of randomization
12. Active autoimmune diseases, including but not limited to inflammatory bowel disease,
such as ulcerative colitis or Crohn 's disease, that require systemic treatment
( such as the use of disease-modifying drugs, corticosteroids or immunosuppressants
), have occurred within the first two years of the randomization; diverticulitis;
chylous diarrhea; systemic lupus erythematosus; sarcoidosis syndrome or wegener
syndrome ( granuloma with polyangiitis); graves' disease; rheumatoid arthritis;
multiple sclerosis; vasculitis; glomerular nephritis; antiphospholipid syndrome;
pituitary inflammation; uveitis, etc. Alternative therapies (such as thyroxine,
insulin, or physiological doses of corticosteroids for adrenal or pituitary
dysfunction) are not considered as systemic treatments. Patients with positive
autoimmune antibodies need to be evaluated by researchers to confirm that there is
no autoimmune disease that requires systemic treatment before they can be enrolled
13. Primary immunodeficiency disease
14. Previous or current myocarditis
15. Not fully recovered from toxicity and/or complications caused by any intervention
before randomization (> grade 1 or not recovery to baseline)
16. peripheral neuropathy ≥ grade 2
17. Hereditary bleeding tendency or coagulation dysfunction, or a history of thrombosis:
There have been any arterial thrombosis, embolism or ischemia, such as myocardial
infarction, unstable angina, cerebrovascular accident or transient ischemic attack,
pulmonary embolism.within the previous 6 months of randomization. Have a history of
deep vein thrombosis or any other serious thromboembolism (implantable venous access
port or catheter-derived thrombosis, or superficial venous thrombosis is not
considered thromboembolism) within the previous 3 months of randomization
18. Non-squamous NSCLC subjects who were unable or unwilling to receive folic acid or
vitamin B12 supplementation
19. Any unstable systemic disease or concurrent disease, including but not limited to:
1）Active infection ( requiring anti-infective drugs or systemic anti-infective drugs used
within the previous week of randomization ) ; 2）congestive heart failure [New York Heart
Association, NYHA ≥ grade II]； 3）Severe arrhythmia, liver, kidney, or metabolic disease
requiring medical treatment； 4）Untreated coronary atherosclerotic heart disease； 5）Have a
history of gastrointestinal perforation and / or fistula, a history of intestinal
obstruction, extensive bowel resection or long-term chronic diarrhea within the previous
6 months.
20.Received solid organ or blood system transplantation
21.Have a history of HIV infection (HIV1/2 antibody positive), active syphilis
22.Tuberculosis, which is active or requires medical intervention at this stage,
including but not limited to pulmonary tuberculosis
23.Active Hepatitis B Subjects with hepatitis B who met the following criteria met the
inclusion criteria: HBsAg (+) or HBcAb (+), HBV viral load < 2000 copies/ml or <
200 IU/ml or lower than the detection limit HBsAg Subjects with anti-HBc (+), HBsAg (-),
anti-HBs (-) and HBV viral load (-) do not need to receive prophylactic anti-HBV
treatment, but need to closely monitor whether the virus is reactivated
24.Active hepatitis C (HCV antibody positive and HCV-RNA level above the detection limit)
25.Patients with malignant tumors other than confirmed NSCLC within the first 5 years of
randomization, except for fully treated cervical carcinoma in situ, basal cell or
squamous cell skin cancer, local prostate cancer after radical surgery, ductal carcinoma
in situ after radical surgery, and thyroid papillary carcinoma after radical surgery
26.Sintilimab and/or selected chemotherapy regimens (non-squamous NSCLC : pemetrexed plus
cisplatin or carboplatin ; squamous NSCLC : Albumin paclitaxel plus cisplatin or
carboplatin) active ingredients and/or any excipients have allergic reactions
27.Pregnant or lactating women or women preparing to be pregnant or lactating during the
study period
28.Subjects are mental illness or drug abuse that may have an impact on compliance with
the test requirements, and have a history of alcohol abuse
29.Subjects with medical history, disease, treatment or laboratory abnormality which may
interfere with the results of the trial, prevent the subject from participating in the
study throughout the study, or the researchers believe that subjects in the study can not
get the best interests of the subject Local or systemic diseases caused by non-malignant
tumors, or secondary reactions to cancer, can lead to higher medical risks and/or
uncertainty in survival evaluation.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Start date:
August 1, 2024
Completion date:
August 1, 2026
Lead sponsor:
Agency:
Tang-Du Hospital
Agency class:
Other
Source:
Tang-Du Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06485557
