Mechanisms for Laser-Induced Rejuvenation

Trial Title: Mechanisms for Laser-Induced Rejuvenation

NCT ID: NCT06489301

Condition: Skin Cancer

Conditions: Official terms:
Skin Neoplasms

Study type: Interventional

Study phase: N/A

Overall status: Not yet recruiting

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Intervention model description: All subjects will receive fractionated laser resurfacing.

Primary purpose: Prevention

Masking: None (Open Label)

Intervention:

Intervention type: Device
Intervention name: Fractionated Laser Resurfacing
Description: A rejuvenating laser that makes tiny holes in the very superficial part of the skin.
Arm group label: Fractionated Laser Resurfacing

Summary: It has shown that laser wounding of geriatric skin protects it against skin cancer. The purpose of this study is to determine the origin of cells called fibroblasts which are present after treatment with Fractionated Laser Resurfacing (FLR). These cells restore a youth-like ultraviolet B (UVB) response, but where they come from is currently unknown. The study recruits subjects who are scheduled to undergo abdominoplasties to investigate the origin of those cells stimulated by laser treatment.

Criteria for eligibility:
Criteria:
Inclusion Criteria: - Adult males and females 18 and older - Able to comprehend procedures and risks - Planning to undergo abdominoplasty surgery - Minimum amount of skin to be removed is 50 x 20cm Exclusion Criteria: - Medical history of not well-controlled diabetes. This is defined as a subject who needs high doses of insulin, recent history of hospitalization for diabetes-related complications, or poor wound health as evidenced by diabetic ulcers. Subjects who have been deemed healthy enough for abdominoplasty surgery would tend to suggest that their diabetes should not be an issue. However, if the subjects have diabetic complications as outlined above, they could affect the wound healing which is the object of this protocol so they would be excluded. - Pregnant or nursing - History of pathologically abnormal wound healing such as keloidal scars - Existing tattoos on the abdomen that are so extensive that they could interfere with the study

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: Wright State Physicians

Address:
City: Fairborn
Zip: 45324
Country: United States

Start date: January 2025

Completion date: December 2028

Lead sponsor:
Agency: Wright State University
Agency class: Other

Source: Wright State University

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06489301