Nab-Sirolimus and Endocrine Therapy in Recurrent Low Grade Serous Ovarian Cancer (NARETO)

Trial Title: Nab-Sirolimus and Endocrine Therapy in Recurrent Low Grade Serous Ovarian Cancer (NARETO)

NCT ID: NCT06494150

Condition: Low Grade Ovarian Serous Adenocarcinoma

Conditions: Official terms:
Ovarian Neoplasms
Carcinoma, Ovarian Epithelial
Cystadenocarcinoma, Serous
Sirolimus
Fulvestrant

Conditions: Keywords:
Ovarian Cancer
Endocrine Therapy

Study type: Interventional

Study phase: Phase 2

Overall status: Not yet recruiting

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Intervention model description: A single arm phase II study proposes to evaluate the efficacy and safety of nab-sirolimus + endocrine therapy in patients with recurrent LGSOC.

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: nab-Sirolimus
Description: nab-Sirolimus will be administered by intravenous infusion at 100mg/m2 on days 1 and 8 of each 21-day cycle
Arm group label: nab-sirolimus + Fulvestrant

Other name: Fyarro

Intervention type: Drug
Intervention name: Fulvestrant
Description: Fulvestrant will be administered by intramuscular injection at 500mg on days 1 and 15 of cycle 1 and then every 21 days
Arm group label: nab-sirolimus + Fulvestrant

Other name: Faslodex

Summary: This single arm phase II study proposes to evaluate the efficacy and safety of nab-sirolimus + endocrine therapy (Fulvestrant) in patients with recurrent low grade serous ovarian cancer (LGSOC).

Detailed description: Patients with histologic confirmed Low Grade Serous Ovarian Cancer with measurable disease should have a pre-dose tumor biopsy. Patients will receive proposed treatment regimen of nab-sirolimus on days 1 and 8 and fulvestrant on days 1 and 15 of cycle 1 and then every 21-day cycle as long as there is evidence that tumor is not growing or spreading and they are not having any unacceptable, bad side effects. Patients will be monitored during treatment with tests and exams and after treatment completion for up to 2 years.

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. Patients must have a histologic confirmed low-grade serous ovarian cancer with clinical evidence of reoccurrence. 2. All patients must have measurable disease as defined by RECIST version 1.1. 3. ECOG Performance status must be 0-1. 4. Adequate bone marrow, hepatic and renal function as defined by the protocol. 5. At least 4 weeks must have elapsed since the patient underwent any major surgery. 6. At least 2 weeks must have elapsed since the patient received any radiation therapy. 7. Patients must have signed an IRN approved informed consent and authorization permitting release of personal health information. 8. All patients must be at least 18 years of age. 9. Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial. 10. Patients of childbearing potential must have a negative serum pregnancy test prior to the study entry and be practicing a highly effective form of contraception. During the study treatment and for 6 months after stopping the treatment. Highly effective contraceptive methods include combination of any two of the following: Exclusion Criteria: 1. Patients who have previously received nab-sirolimus, any other mTOR inhibitor or any agent targeting the PI3K/AKT/mTOR pathway. (Prior MEKi is not exclusionary; up to one prior cytotoxic therapy is permissible.) 2. Known intolerance or hypersensitivity to nab-sirolimus or other rapamycin analogs (e.g. sirolimus, temsirolimus). 3. Patients receiving chronic treatment with systemic steroids or another immunosuppressive agent if >10 mg prednisone equivalent per day 4. Patients with active or uncontrolled systemic infection requiring IV antibiotics, either ongoing or completed ≤7 days prior to enrollment. 5. Known severely impaired lung function, including: - CTCAE grade 2 (or greater) hypoxia (decreased oxygen saturation with exercise [e.g., pulse oximeter <88%]; intermittent supplemental oxygen) 6. Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification 1. To be eligible for this trial, patients should be class 2B or better. 7. Cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) within 6 months prior to the first date of study therapy. 8. Patients who are hypersensitive to albumin. 9. Patients who are pregnant or breast-feeding. 10. Patients with brain metastases. Patients recently treated for brain metastases are eligible as long as they have been off steroids or RT for at least 2 weeks. 11. Known HIV-infected patients requiring anti-retroviral therapy that are strong CYP3A4 inhibitors or inducers. 12. Patients with active bleeding or pathologic conditions that carry high risk of bleeding, such as known bleeding disorder or coagulopathy. 13. Patients who are currently part of or have participated in any clinical investigation with an investigational drug within 28 days prior to dosing or 5 half-lives whichever is shorter. 14. Active Hepatitis B or Hepatitis C, with detectable viral load. - For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated. Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load. 15. Uncontrolled hypertension (systolic blood pressure ≥160 mm-Hg and/or diastolic blood pressure ≥100 mm Hg). 16. Patients who are unable to discontinue concomitant medication with CYP3A4 strong inducers (eg, rifampin, rifabutin), and known CYP3A4 substrates with a narrow therapeutic window (eg, fentanyl, alfentanil, astemizole, cisapride, dihydroergotamine, pimozide, quinidine, or terfenadine) at least 5 half-lives prior to receiving the first dose of nab-sirolimus. Medical Monitor approval required if patient is taking any of the medications listed above.

Gender: Female

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: No

Locations:

Facility:
Name: OU Health Stephenson Cancer Center

Address:
City: Oklahoma City
Zip: 73117
Country: United States

Contact:
Last name: Christina Washington, MD

Phone: 405-271-8777
Email: SCC-IIT-Office@ouhsc.edu

Investigator:
Last name: Christina Washington, MD
Email: Principal Investigator

Start date: October 2024

Completion date: September 2029

Lead sponsor:
Agency: University of Oklahoma
Agency class: Other

Collaborator:
Agency: Aadi Bioscience, Inc.
Agency class: Industry

Source: University of Oklahoma

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06494150