HRYZ-T102 TCR-T Cell for AFP Positive Advanced HCC and Other Solid Tumors

Trial Title: HRYZ-T102 TCR-T Cell for AFP Positive Advanced HCC and Other Solid Tumors

NCT ID: NCT06515314

Condition: Hepatic Cell Carcinoma

Conditions: Official terms:
Carcinoma
Carcinoma, Hepatocellular

Study type: Interventional

Study phase: Phase 1

Overall status: Recruiting

Study design:

Allocation: N/A

Intervention model: Single Group Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Biological
Intervention name: AFP Specific T Cell Receptor T Cells
Description: AFP Specific T Cell Receptor T Cells On day 1, the TCR-T cells will be administered intravenously. Drug: Fludarabine + Cyclophosphamide Fludarabine: 25mg/m²/day×3days; Cyclophosphamide: 250mg/m²/day×3 days
Arm group label: HRYZ-T102 Injection

Summary: This is a single arm, open-label, dose escalation clinical study to evaluate the safety and efficacy of HRYZ-T102 TCR-T Cell in patients with AFP positive advanced hepatocellular carcinoma and other solid tumors refractory to prior systematic treatments.

Detailed description: This study plans to enroll 12-24 patients to assess the safety of HRYZ-T102. Subjects who meet the eligibility criteria will receive a single dose of HRYZ-T102 injection .The patient will be followed up 24 months.

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. The patient must be willing to sign the informed consent form. 2. Age ≥18 years and ≤75 years. 3. HLA-A 02:03 allele positive 4. Histologically-confirmed AFP positive hepatocellular carcinoma (HCC) or other solid tumor, No benefits from curative surgery or other local therapies are expected ,at least one prior line of systematic treatment at screening, judged by investigators. 5. Fresh samples or formalin-fixed paraffin-embedded (FFPE) samples, immunohistochemistry (IHC)-stained AFP positive or serum AFP ≥400ng/ml. 6. Barcelona Clinic Liver Cancer (BCLC) stage C or B and Child-Pugh ≤7 7. ECOG performance status ≤1. 8. Estimated life expectancy ≥4 months. 9. Patients must have at least one measurable lesion defined by RECIST 1.1. 10. Patients with any organ dysfunction as defined below: Leukocytes≥3.0 x 10^9/L; blood platelets ≥75 x 10^9/L; hemoglobin≥85g/L; Absolute lymphocyte count≥0.8 x 10^9/L Serum albumin ≥ 30g/L; total bilirubin≤3×ULN; ALT/AST≤3×ULN ; Creatinine clearance ≥50mL/min; or serum creatinine ≤1.5×ULN; INR≤1.5×ULN; APTT≤1.5×ULN; LVEF≥50%; SpO2≥92%. 11. Subjects with potential fertility must agree to use effective contraceptive methods during the whole trials period and at least 1 year after receiving HRYZ-T102 cell transfusion treatment. HCG test for female with potential fertility must be negative within 7 days before apheresis. Exclusion Criteria: 1. Toxicity of previous treatment has not been mitigated or ≤ Grade 1 at screening. 2. Another primary malignancy within 5 years (with some exceptions for completely-resected early-stage tumors) 3. With severe cardiovascular disease or presence of clinically-relevant central nervous system (CNS) disorders in six months before screening. 4. Systematic autoimmune disorders requiring long-term systematic immunosuppression 5. Have a history of hypersensitivity to cyclophosphamide or fludarabine, and it is known that any ingredient used in the treatment of this study will produce allergic reactions. 6. Current presence of or previously with hepatic encephalopathy 7. Organ transplanters and allogeneic cell transplanters. 8. Have a history of gastrointestinal bleeding or a definite tendency to gastrointestinal bleeding within 3 months before screening 9. Hereditary or acquired bleeding (e.g. coagulation dysfunction) or a tendency to clot 10. Subject has active infection or unexplained fever during screening and prior to cell transfusion 11. Have central nervous system metastasis with symptoms 12. Known HIV or syphilis infection, and/or active hepatitis C virus infection. 13. HBV infect subjects with HBV-DNA≥2000IU/ml 14. Pregnant or lactating female, or those whose HCG test is positive before enrollment. 15. Known uncontrolled diabetes, pulmonary fibrosis, interstitial lung disease, acute lung disease or liver failure

Gender: All

Minimum age: 18 Years

Maximum age: 75 Years

Healthy volunteers: No

Locations:

Facility:
Name: Zhongshan Hospital Affiliated to Fudan University

Address:
City: Shanghai
Country: China

Status: Recruiting

Contact:
Last name: Xiaowu Huang, Doctor

Start date: August 10, 2024

Completion date: August 10, 2027

Lead sponsor:
Agency: HRYZ Biotech Co.
Agency class: Industry

Source: HRYZ Biotech Co.

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06515314