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Trial Title:
Prevalence of Long-term Dental Effects of Chemotherapy in Childhood Cancer Survivors Diagnosed With Cancer Before the Age of 10
NCT ID:
NCT06517927
Condition:
Chemotherapy Effect
Dental Caries
Malocclusion
Childhood Cancer
Tooth Defect
Conditions: Official terms:
Dental Caries
Malocclusion
Conditions: Keywords:
Childhood cancer survivors
Dental defect
Study type:
Interventional
Study phase:
N/A
Overall status:
Recruiting
Study design:
Allocation:
Non-Randomized
Intervention model:
Parallel Assignment
Intervention model description:
Interventionnal study, cohort study
Primary purpose:
Diagnostic
Masking:
None (Open Label)
Intervention:
Intervention type:
Diagnostic Test
Intervention name:
Clinical and radiographic dental examination
Description:
complete clinical oral examination + intra-oral and panoramic x-rays
Arm group label:
Cancer survivor
Arm group label:
Control
Summary:
To date, there are no methods for assessing the risk of oral developmental defects that
could predict long-term adverse effects in cancer survivors. Having such a method at our
disposal would enable us to better assess the risk and develop new prevention and
treatment strategies to ensure the patient's healthy oral development.
The aims of this study are:
- Assess the caries risk in childhood cancer survivors compared with a control group.
- Assess the dental development defects risk in childhood cancer survivors compared
with a control group.
Detailed description:
This will be an interventionnal study comparing the Childhood Cancer Survivors (CCS) and
a control group.
A questionnaire will be provided to the patients to gather information. A standard of
care dental examination will then take place in a dental office in the Cliniques
Universitaires Saint-Luc. We also collecting medical data to complete the files.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- age below 10 at cancer diagnosis (for the CCS group).
- Chemotherapy must have been used to treat the patient (For the CCS group).
- The patient is 12 years old or older at the time of the follow-up appointment of the
present study
Exclusion Criteria:
- A patient who was diagnosed and treated after 10 years old.
- Patient below 12 years old at time of study recruitment
- Patients with syndrome or diseases that involve teeth impairment*
- Pregnant patient
- Refusal or inaptitude to undergo dental and radiographic examination
Gender:
All
Minimum age:
12 Years
Maximum age:
36 Years
Healthy volunteers:
No
Locations:
Facility:
Name:
Cliniques universitaires Saint-Luc
Address:
City:
Brussels
Zip:
1200
Country:
Belgium
Status:
Recruiting
Contact:
Last name:
Maëlle De Ville de Goyet
Email:
maelle.deville@saintluc.uclouvain.be
Start date:
May 3, 2024
Completion date:
May 3, 2026
Lead sponsor:
Agency:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Agency class:
Other
Source:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06517927
