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Trial Title:
MOLyF : Bone Marrow and Follicular Lymphoma
NCT ID:
NCT06608147
Condition:
Lymphoma, Follicular
Conditions: Official terms:
Lymphoma
Lymphoma, Follicular
Study type:
Interventional
Study phase:
N/A
Overall status:
Not yet recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Basic Science
Masking:
None (Open Label)
Intervention:
Intervention type:
Other
Intervention name:
Sampling
Description:
sternal bone marrow aspiration
Arm group label:
Experimental
Summary:
This is a prospective single-center study designed to assess potential differences in
cell composition between bone marrows of patients with follicular lymphoma and those from
control subjects.
Follicular lymphoma is the most common indolent lymphoma. It is characterised by
systematic relapses and bone marrow dissemination in 70% of patients at the time of
diagnosis.
Although relapses are thought to be related to refractory tumour cells nested in a
supportive microenvironment in the bone marrow, the mechanisms involved are poorly
understood.
To study the specificities of the bone marrow of patients with follicular lymphoma, It is
necessary to compare them with control samples.
This study takes advantage of surgeries involving sternotomies to recover lost bone
marrow and establish a bone marrow bank of patients without hematological disease.
This bank will be used to set up control cohorts for other clinical trials involving
patients with follicular lymphoma.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Major patient
- Patient hospitalized in the thoracic, cardiac and vascular surgery department for
surgery involving a sternotomy
- Patient with free, informed, written consent
- Patient covered by a health insurance scheme
Exclusion Criteria:
- History of haematological malignancy or haemogram disturbance
- Immunomodulating treatment: immunosuppressants, corticoids, antineoplastics
- Persons covered by articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French
Public Health Code (e.g. minors, protected adults, etc.)].
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
Accepts Healthy Volunteers
Locations:
Facility:
Name:
CHU Rennes
Address:
City:
Rennes
Zip:
35009
Country:
France
Contact:
Last name:
Juliette Ferrant, MD
Phone:
0299282555
Phone ext:
+33
Email:
juliette.ferrant@chu-rennes.fr
Contact backup:
Last name:
Juliette Ferrant, MD
Start date:
October 1, 2024
Completion date:
October 1, 2034
Lead sponsor:
Agency:
Rennes University Hospital
Agency class:
Other
Source:
Rennes University Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06608147
