Exercise and Nutrition for Older Cancer Survivors and Their Support Person: the Vitality Study

Trial Title: Exercise and Nutrition for Older Cancer Survivors and Their Support Person: the Vitality Study

NCT ID: NCT06623097

Condition: Cancer Survivorship

Conditions: Keywords:
Cancer Survivorship

Study type: Interventional

Study phase: N/A

Overall status: Not yet recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Supportive Care

Masking: None (Open Label)

Intervention:

Intervention type: Behavioral
Intervention name: Supervised Exercise and Diet Program
Description: A home-based, virtually supervised, moderate-to-vigorous aerobic and resistance exercise intervention with a certified cancer exercise trainer. The exercise sessions will include aerobic exercise on a stationary bicycle and total-body resistance training using resistance bands. Stationary bicycle, resistance bands, activity tracking watch, and Wi-Fi enabled tablet (if needed) will be provided to participants. Dyads will receive remotely delivered nutrition coaching sessions (via telephone or video conferencing) with a health coach each week. Mediterranean eating pattern goals will be tracked using the journal feature of the My Wellness Research platform website.
Arm group label: Arm 1: Virtually Supervised Care Comparator

Intervention type: Behavioral
Intervention name: Unsupervised Exercise and Diet Program
Description: A home-based, unsupervised moderate-to-vigorous aerobic and resistance exercise intervention. The exercise sessions will include aerobic exercise on a stationary bicycle and total-body resistance training using resistance bands. Stationary bicycle, resistance bands, activity tracking watch will be provided to participants. Dyads will receive Mediterranean eating pattern goals, with an introductory session conducted by research staff. Diet intake will be tracked using the journal feature My Wellness Research platform website.
Arm group label: Arm 2: Unsupervised Care

Summary: This research study will compare the impact of virtually supervised and unsupervised home-based exercise and diet programs on cognitive function and physical function among cancer survivors and support persons. This study will involve a 6 month home-based virtually supervised or unsupervised exercise and diet intervention. The names of the study interventions involved in this study are: - Virtually supervised exercise and healthy diet care - Unsupervised exercise and healthy diet care

Detailed description: This is a multi-center, parallel arm, comparative effectiveness trial to compare the impact of supervised and unsupervised home-based exercise and diet programs on cognitive function and physical function among cancer survivors and support persons. Participants and support persons in this study will be randomly assigned to one of two groups: Group A: Virtually Supervised Care or Group B: Unsupervised Care. Randomization means a participant is placed into a study group by chance. The research study procedures include screening for eligibility, in-clinic visits, evaluations of fitness, physical health, diet, and cognitive function, surveys, and questionnaires. Participation in this study is expected to last 12 months. It is expected about 1528 people will participate in this research study. Patient Centered Outcomes Research Institute (PCORI) is supporting this research study by providing funding for the study.

Criteria for eligibility:
Criteria:
Inclusion Criteria for Survivor Participants: - Ability to understand and the willingness to sign informed consent prior to any study- related procedures. - Older adults (≥65 years of age); cancer survivors who are at higher risk for developing comorbid conditions related to physical and cognitive function due to age declines. - Completed chemotherapy and/or targeted therapy in the previous 12 months; said treatment exposure negatively impacts cognitive and physical function. - Diagnosed with breast, lung, prostate, or colorectal cancer which are obesity-related cancers with higher risk for developing comorbid conditions related to physical and cognitive function. - No detection of limiting cognitive impairment as measured by scoring ≥20 on the MoCA; moderate or severe cognitive impairment could impact ability to complete testing and intervention safely. - Overweight/obese: BMI ≥25 kg/m2 (calculated using height and weight) or body fat >35% for people assigned female at birth and >25% for people assigned male at birth (estimated by bioelectrical impedance); higher body weight negatively impacts cognitive and physical function. - Currently participating in <60 minutes of structured moderate-to-vigorous exercise per week (determined by screening questionnaire); sedentary cancer survivors have a higher need and are more likely to benefit from exercise exposure. - No history of disordered eating; to avoid triggering of past eating disorders with a diet intervention program. - Reside with an (≥18 years of age) informal support person willing to participate; survivor/support person dyads will participate in the trial together per the goals of the trial and finding mechanism. - Speak English or Spanish; the study teams will only be able to accommodate for these two languages at this time. - Willing to travel to the respective site for necessary data collection. Inclusion Criteria for Support Person: - Adults ≥18 years of age; the intervention is not designed for adolescent and pediatric populations. - No detection of limiting cognitive impairment as measured by scoring ≥20 on the MoCA; moderate or severe cognitive impairment could impact ability to complete testing and intervention safely. - No history of disordered eating; to avoid triggering of past eating disorders with a diet intervention program. - Speak English or Spanish; the study teams will only be able to accommodate for these two languages at this time. Exclusion Criteria for Survivor Participants: - Adult cancer survivors less than 65 years of age. - Survivors with a MoCA score <20. - Survivors with a BMI &lt; 25 kg/m2 and body fat <35% for people assigned female at birth and <25% for people assigned male at birth. - Survivors currently consuming a Mediterranean Diet or meeting 2 or more out of the following 3 Mediterranean eating pattern goals in the prior 6 weeks: ≥3 servings of vegetables per day, ≥ 3 servings of beans and legumes per week, or ≥ 1 serving of nuts per day. - Survivors with unstable comorbidities that prevent participation in moderate-to-vigorous intensity exercise. Persons with unstable comorbidities may develop unexpected adverse events from exercise. For the purpose of participant safety, as well as because this study involves remote, home-based exercise where close supervision is not possible, participants with unstable medical conditions will be excluded. This will be evaluated through the PAR- Q. - Subjects with severe psychiatric conditions such as Active Major Depression, Bipolar Disorder, significant Suicidal ideation, and an active substance use and/or substance abuse disorder; these conditions can 1) adversely affect important cognitive test measures and 2) the ability to complete certain circumscribed interventions in the study. As a result, we will employ the Mini-International Neuropsychiatric Interview (M.I.N.I.) for the diagnosis of such conditions. For those who exhibit these conditions on the MINI, this will be considered as an exclusionary criterion, and the person will be immediately referred to the local Risk Management office. - Subjects who in the opinion of the investigator may not be able to comply with the safety monitoring requirements of the study. - Survivors receiving treatment for an active malignancy (exceptions are treatment for basal cell carcinoma. They may receive long term treatments for their diagnosed breast, lung, prostate or colorectal cancer including hormone therapy). This study is exclusively targeting survivors post-primary cancer treatment. Exclusion Criteria for Support Person: - Support persons less than 18 years of age. - Support persons with a MoCA score <20. - Given the age range of support persons include those in childbearing years, people who are pregnant, or plan to become pregnant during study duration will be excluded due to the unknown nature of exercise on developing fetuses. - Support persons with unstable comorbidities that prevent participation in moderate-to- vigorous intensity exercise. Persons with unstable comorbidities may develop unexpected adverse events from exercise. For the purpose of participant safety, as well as because this study involves remote, home-based exercise where close supervision is not possible, participants with unstable medical conditions are excluded. - Support persons with severe psychiatric conditions such as Active Major Depression, Bipolar Disorder, significant Suicidal ideation, and an active substance use and/or substance abuse disorder; these conditions can 1) adversely affect important cognitive test measures and 2) the ability to complete certain circumscribed interventions in the study. As a result, we will employ the Mini-International Neuropsychiatric Interview (M.I.N.I.) for the diagnosis of such conditions. For those who exhibit these conditions on the MINI, this will be considered as an exclusionary criterion, and the person will be immediately referred to the local Risk Management office. - Support persons receiving treatment for an active malignancy or are <10 years from the completion of any cancer treatment (exceptions are treatment for basal cell carcinoma). This is to preserve the "role" of the cancer survivor in the dyad.

Gender: All

Minimum age: 18 Years

Maximum age: N/A

Healthy volunteers: Accepts Healthy Volunteers

Locations:

Facility:
Name: Dana-Farber Cancer Institute

Address:
City: Boston
Zip: 02215
Country: United States

Contact:
Last name: Christina Dieli-Conwright, PhD, MPH

Phone: 617-632-3800
Email: ChristinaM_Dieli-Conwright@dfci.harvard.edu

Contact backup:
Last name: Christina Dieli-Conwright, PhD

Start date: March 2025

Completion date: April 30, 2030

Lead sponsor:
Agency: Dana-Farber Cancer Institute
Agency class: Other

Collaborator:
Agency: Patient-Centered Outcomes Research Institute
Agency class: Other

Source: Dana-Farber Cancer Institute

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06623097