Trial Title:
A Phase II, Single-center, Single-arm Study Evaluating the Safety and Efficacy of Golidocitinib in the Management of Newly Diagnosed Peripheral T Cell Lymphoma Patients (GOLDEN Study) and Correlative Study
NCT ID:
NCT06630091
Condition:
Peripheral T Cell Lymphoma
Conditions: Official terms:
Lymphoma
Lymphoma, T-Cell
Lymphoma, T-Cell, Peripheral
Prednisone
Cyclophosphamide
Doxorubicin
Vincristine
Study type:
Interventional
Study phase:
Phase 2
Overall status:
Not yet recruiting
Study design:
Allocation:
N/A
Intervention model:
Single Group Assignment
Primary purpose:
Treatment
Masking:
None (Open Label)
Intervention:
Intervention type:
Drug
Intervention name:
Golidocitinib
Description:
150 mg once per day by PO
Arm group label:
Golidocitinib + CHOP
Intervention type:
Drug
Intervention name:
Cyclophosphamide
Description:
750 mg/m2 by IV
Arm group label:
Golidocitinib + CHOP
Intervention type:
Drug
Intervention name:
Doxorubicin
Description:
50 mg/m2 by IV
Arm group label:
Golidocitinib + CHOP
Intervention type:
Drug
Intervention name:
Vincristine
Description:
1.4 mg/m2 (max: 2 mg) by IV
Arm group label:
Golidocitinib + CHOP
Intervention type:
Drug
Intervention name:
Prednisone
Description:
100 mg by PO
Arm group label:
Golidocitinib + CHOP
Summary:
To learn if the study drug golidocitinib given alone or in combination with the standard
drug combination therapy called CHOP can help to control PTCL.
Detailed description:
Primary Objectives
• To assess the 2-year progression-free survival rate of golidocitinib as primary
efficacy endpoint in participants with newly diagnosed PTCL.
Secondary Objectives
- To assess the anti-tumor efficacy of golidocitinib using PET/CT-based objective
response rate (ORR), complete response rate (CRR), duration of response (DoR),
progression-free survival (PFS), and time to response (TTR) assessed according to
the 2014 Lugano classification as secondary efficacy endpoint in patients with newly
diagnosed PTCL.
- To assess the safety and tolerability of golidocitinib in participants with newly
diagnosed PTCL according to the adverse events graded by CTCAE version 5.0.
Exploratory Objectives
- To identify participant selection biomarkers derived from tumor and plasma at
baseline and correlate these biomarkers with tumor response to golidocitinib.
- Evaluate potential mechanisms of resistance to golidocitinib in plasma and tumor
biopsies of PTCL participants at baseline and upon progression.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- Provision of a signed and dated, written informed consent form prior to any study
specific procedures, sampling, and analyses.
- Submission of the tumor block or unstained slides from an excisional or core biopsy
from nodal or extra-nodal lymphoma tissue (archived or newly obtained sample) is
required for retrospective central confirmation of tumor histological subtype.
- Aged ≥ 18 years old.
- Participants must exhibit Eastern Cooperative Oncology Group (ECOG) performance
status 0-2 with no deterioration over the previous 2 weeks.
- Predicted life expectancy ≥ 12 weeks.
- Participants must have histologically confirmed peripheral T-cell lymphoma by MD
Anderson pathology review according to the 2016 revision of the World Health
Organization classification of lymphoid neoplasms53. Eligible histological subtypes
are restricted to the following:
- PTCL, not otherwise specified (PTCL, NOS) (the proportion of PTCL-NOS subtype
will not exceed 30% of all enrolled)
- Angioimmunoblastic T-cell lymphoma (AITL)
- Follicular T cell lymphoma
- PTCL with T follicular helper (TFH) phenotype
- Participants must have measurable disease according to the 2014 Lugano
classification, which is defined as lymphomatous nodes, nodal masses, or other
lymphomatous lesions are measurable in two diameters (longest diameter [LDi] and
shortest diameter perpendicular to the LDi [SDi]) on CT scans, and also with LDi as
below:
- A measurable node must have an LDi greater than 1.5 cm.
- A measurable extranodal lesion should have an LDi greater than 1.0 cm.
- Participants must be treatment naïve with no prior systemic treatment for T-cell
lymphoma (i.e., PTCL). Participants could be transplant eligible or ineligible upon
their entries to this study.
- Adequate bone marrow reserve and organ system functions, as outlined below:
- Absolute neutrophil count (ANC) ≥ 1 ×109/L (≥0.5 ×109/L if documented bone
marrow involvement with lymphoma) independent of growth factor support within 7
days of study entry.
- Platelets ≥ 75 × 109/L (or ≥ 50 × 109/L if documented bone marrow involvement
with lymphoma) independent of growth factor support or transfusion within 7
days of study entry.
- Hemoglobin ≥ 8 g/dL
- Total bilirubin ≤ 1.5 ×ULN if no liver involvement or ≤ 3 ×ULN in the presence
of documented Gilbert's Syndrome (unconjugated hyperbilirubinemia) or liver
involvement.
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 ×
ULN, or ≤ 5 ×ULN if with document hepatic involvement with lymphoma.
- Creatinine ≤ 1.5 × ULN, OR calculated or measured creatinine clearance ≥ 50
mL/min as calculated by the Cockcroft-Gault method, or 24-hour measured urine
creatinine clearance ≥ 50 mL/min.
- LVEF ≥ 50% assessed by ECHO or MUGA.
- Participants should have the ability and willingness to comply with the study and
follow up.
- The effects of golidocitinib on the developing human fetus are unknown. For this
reason and because JAK1 inhibitor agents as well as other therapeutic agents used in
this trial are known to be teratogenic, women of child-bearing potential and men
must agree to use adequate contraception (hormonal or barrier method of birth
control; abstinence) prior to study entry and for the duration of study
participation. This includes all female patients, between the onset of menses (as
early as 8 years of age) and 55 years unless the participants presents with an
applicable exclusionary factor which may be one of the following:
- Postmenopausal (no menses in greater than or equal to 12 consecutive months).
- History of hysterectomy or bilateral salpingo-oophorectomy.
- Ovarian failure (Follicle Stimulating Hormone and Estradiol in menopausal
range, who have received Whole Pelvic Radiation Therapy).
- History of bilateral tubal ligation or another surgical sterilization
procedure.
- Approved methods of birth control are as follows: Hormonal contraception (i.e. birth
control pills, injection, implant, transdermal patch, vaginal ring), Intrauterine
device (IUD), Tubal Ligation or hysterectomy, Subject/Partner post vasectomy,
Implantable or injectable contraceptives, and condoms plus spermicide. Not engaging
in sexual activity for the total duration of the trial and the drug washout period
is an acceptable practice; however periodic abstinence, the rhythm method, and the
withdrawal method are not acceptable methods of birth control. Should a woman become
pregnant or suspect she is pregnant while she or her partner is participating in
this study, she should inform her treating physician immediately.
- Women treated or enrolled on this protocol must agree to use adequate contraception
prior to the study, for the duration of study participation, and 4 months after
completion of golidocitinib administration. If female patients wish to mother
children, they should be advised to arrange for freezing of eggs prior to the start
of study treatment.
- Men treated or enrolled on this protocol must also agree to use adequate
contraception prior to the study, for the duration of study participation, and 4
months after completion of golidocitinib administration. Men must refrain from
donating sperm during their participation in the study and at least for 6 months
after the last treatment. If male patients wish to father children, they should be
advised to arrange for freezing of sperm samples prior to the start of study
treatment.
Exclusion Criteria:
Participants must not enter the study if any of the following exclusion criteria are
fulfilled:
- Intervention with any of the following:
- Any investigational anti-cancer agents or anti-cancer study drugs from a
previous clinical study.
- Any cytotoxic chemotherapy from a previous treatment regimen.
- Corticosteroids at dosages equivalent to prednisone > 40 mg/day within 7 days
of the start of the study treatment.
- Major surgery procedure (excluding placement of vascular access), or
significant traumatic injury within 4 weeks of the first dose of study
treatment, or have an anticipated need for major surgery during the study.
- Prior treatment with a JAK or STAT3 inhibitor.
- Prior treatment with any onco-immunotherapy in 28 days prior to first dosing of
golidocitinib (e.g., immune checkpoint inhibitors PD-1, PD-L1, CTLA4).
- Live vaccines within 28 days prior to first dose.
- Participants currently receiving (or unable to stop use at least 1 week prior
to receiving the first dose) medications or herbal supplements known to be
Potent inhibitors or inducers of CYP3A .
- Central nervous system or leptomeningeal lymphoma given the lack of evidence of CNS
penetrance of the investigational drug.
- Participants with severely decreased lung function (i.e. any parameter of FEV1, and
DLCO < 60% of predicted value). Past medical history of pneumonitis, drug-induced
interstitial lung disease, radiation pneumonitis which required steroid treatment,
or any evidence of clinically active interstitial lung disease.
- Participants with disease condition which requires the treatment of
immunosuppressants, biologics, or NSAIDs (non-steroid anti-inflammatory drugs).
- Active infections including
- History of known active tuberculosis (TB).
- Known infection with human immunodeficiency virus (HIV).
- Known active hepatitis B or hepatitis C infection as follows
- Active viral infections (i.e., zoster) other than hepatitis B or C.
o Infections requiring oral or intravenous antimicrobial therapy or interferon
within 14 days.
- Any of the following cardiac criteria:
- Congestive heart failure (CHF) per New York Heart Association (NYHA)
classification > Class II .
- Clinically significant valvular diseases, hypertrophic or constrictive
cardiomyopathy.
- Any clinically significant abnormalities in rhythm, conduction or morphology of
resting ECG, e.g., complete left bundle branch block, third degree heart block,
and second-degree heart block, PR interval > 250 msec.
- Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy.
- Acute Myocardial Infarction (AMI) within 6 months prior to starting treatment,
unstable angina or new-onset angina.
- Participants with heart transplant.
- Mean resting corrected QTcF interval >450 ms on screening electrocardiogram
(ECG).
- Participants with factors that increase the risk of QT prolongation or
arrhythmic events (e.g., congenital long QT syndrome, any concomitant
medication known to prolong the QT interval or family history of long QT
interval syndrome or unexplained sudden death under 40 years of age in first
degree relatives).
- Participants with acute thrombotic diseases such as pulmonary embolism (PE) and
deep venous thrombosis (DVT) within 90 days. Participants with remote history
(>6 months) of provoked PE or DVT (e.g., line-associated DVT; DVT or PE after
surgical procedure), and participants on appropriate anticoagulation for 90 or
more days from the event will not be excluded.
- Another malignancy within 5 years prior to enrollment with the exception of
adequately treated in-situ carcinoma of the cervix, uterus, basal or squamous cell
carcinoma or non-melanomatous skin cancer.
- Refractory nausea and vomiting if not controlled by supportive therapy, chronic
gastrointestinal diseases, inability to swallow the formulated product or previous
significant bowel resection that would preclude adequate absorption of
golidocitinib.
- History of hypersensitivity to active or inactive excipients of golidocitinib or
drugs with a similar chemical structure or class.
- As judged by the investigator, any evidence of severe or uncontrolled systemic
diseases, including uncontrolled hypertension or active bleeding diatheses.
Screening for chronic conditions is not required.
- Concurrent conditions that in the investigator's opinion would jeopardize compliance
with the protocol.
- Psychological, familial, sociological, or geographical conditions that do not permit
compliance with the protocol.
- All participants must avoid concomitant use of medications, herbal supplements
and/or ingestions of foods with known potent inducer/inhibitory effects on CYP3A
activity whenever feasible. Such drugs must have been discontinued for an
appropriate period before they enter screening and for a period after the last dose
of golidocitinib. Guidance on medications to avoid, medications that require close
monitoring and on washout periods.
- Participants with psychiatric illness/social situations that would limit compliance
with study requirements.
- Pregnant women are excluded from this study because golidocitinib is a JAK1
inhibitor agent with the potential for teratogenic or abortifacient effects. Because
there is an unknown but potential risk for adverse events in nursing infants
secondary to treatment of the mother with golidocitinib, breastfeeding should be
discontinued if the mother is treated with golidocitinib. These potential risks may
also apply to other agents used in this study.
Gender:
All
Minimum age:
18 Years
Maximum age:
N/A
Healthy volunteers:
No
Locations:
Facility:
Name:
MD Anderson Cancer Center
Address:
City:
Houston
Zip:
77030
Country:
United States
Contact:
Last name:
Luis o, MD
Phone:
713-563-8954
Email:
lemalpica@mdanderson.org
Investigator:
Last name:
Luis Malpica Castillo, MD
Email:
Principal Investigator
Start date:
March 28, 2025
Completion date:
July 5, 2029
Lead sponsor:
Agency:
M.D. Anderson Cancer Center
Agency class:
Other
Source:
M.D. Anderson Cancer Center
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06630091
http://www.mdanderson.org
