Adebrelimab Combined with Irinotecan Liposomes, 5-FU, CF ± Lenvatinib As First-line Treatment for Advanced ICC

Trial Title: Adebrelimab Combined with Irinotecan Liposomes, 5-FU, CF ± Lenvatinib As First-line Treatment for Advanced ICC

NCT ID: NCT06648525

Condition: Intrahepatic Cholangiocarcinoma (Icc)

Conditions: Official terms:
Cholangiocarcinoma
Leucovorin
Fluorouracil
Irinotecan
Lenvatinib
Calcium
Levoleucovorin

Conditions: Keywords:
Adebrelimab
Irinotecan liposomes
Lenvatinib
Intrahepatic Cholangiocarcinoma

Study type: Interventional

Study phase: Phase 2

Overall status: Not yet recruiting

Study design:

Allocation: Randomized

Intervention model: Parallel Assignment

Primary purpose: Treatment

Masking: None (Open Label)

Intervention:

Intervention type: Drug
Intervention name: Adebrelimab
Description: Adebrelimab, IV
Arm group label: Group A: Adebrelimab+Irinotecan liposomes+5-fluorouracil+calcium folinate+lenvatinib
Arm group label: Group B: Adebrelimab+Irinotecan liposomes+5-fluorouracil+calcium folinate

Intervention type: Drug
Intervention name: Irinotecan liposomes
Description: Irinotecan liposomes, IV
Arm group label: Group A: Adebrelimab+Irinotecan liposomes+5-fluorouracil+calcium folinate+lenvatinib
Arm group label: Group B: Adebrelimab+Irinotecan liposomes+5-fluorouracil+calcium folinate

Intervention type: Drug
Intervention name: Lenvatinib
Description: Lenvatinib, po
Arm group label: Group A: Adebrelimab+Irinotecan liposomes+5-fluorouracil+calcium folinate+lenvatinib

Intervention type: Drug
Intervention name: 5-Fluorouracil (5-FU)
Description: 5-Fluorouracil (5-FU), IV
Arm group label: Group A: Adebrelimab+Irinotecan liposomes+5-fluorouracil+calcium folinate+lenvatinib
Arm group label: Group B: Adebrelimab+Irinotecan liposomes+5-fluorouracil+calcium folinate

Intervention type: Drug
Intervention name: Calcium Folinate
Description: Calcium folinate, IV
Arm group label: Group A: Adebrelimab+Irinotecan liposomes+5-fluorouracil+calcium folinate+lenvatinib
Arm group label: Group B: Adebrelimab+Irinotecan liposomes+5-fluorouracil+calcium folinate

Summary: This is a multicenter, open label, randomized, two-arm clinical study to observe and evaluate the efficacy and safety of adebrelimab combined with irinotecan liposomes, 5-fluorouracil, calcium folinate ± lenvatinib as first-line treatment for advanced intrahepatic cholangiocarcinoma (ICC).

Detailed description: This study plans to recruit 68 patients with unresectable ICC who have not received prior systematic treatment. The patients will be randomly divided into two groups. Group A: patients will receive adebrelimab+irinotecan liposomes+5-fluorouracil+calcium folinate+lenvatinib; Group B: patients will receive treatment with adebrelimab+irinotecan liposomes+5-fluorouracil+calcium folinate. The combination of irinotecan liposomes+5-fluorouracil+calcium folinate will be used 9 times (Q2W), and adebrelimab ± lenvatinib will be used until disease progression or medication for 2 years.

Criteria for eligibility:
Criteria:
Inclusion Criteria: 1. Age: 18 to 75 years old, male or female not limited; 2. Histologically confirmed unresectable locally advanced or metastatic intrahepatic cholangiocarcinoma with measurable tumor lesions (meeting RECIST 1.1 criteria); 3. Have not received systemic anti-tumor treatment in the past; 4. Patients who relapse more than 6 months after curative surgery or after completion of adjuvant therapy (chemotherapy and/or radiotherapy) meet the inclusion criteria; 5. ECOG PS：0-1； 6. Expected survival period ≥ 3 months; 7. The main organ functions are normal, which meets the following criteria: 1) Blood routine examination (without blood transfusion or correction with hematopoietic stimulating factor drugs within 14 days): Hemoglobin (Hb) ≥ 85 g/L; Absolute neutrophil count (ANC) ≥ 1.5 × 109/L; Platelet count (PLT) ≥ 80 × 109/L; 2) Biochemical examination: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 5 × ULN; Serum total bilirubin (TBIL) ≤ 3 × ULN; Serum creatinine (Cr) ≤ 1.5 × ULN or creatinine clearance rate ≥ 50ml/min; 3) Coagulation function: Activated partial thromboplastin time (APTT), international normalized ratio (INR), prothrombin time (PT) ≤ 1.5 × ULN; 4) Doppler ultrasound evaluation: Left ventricular ejection fraction (LVEF) ≥ 50%; 8. Women of childbearing age must undergo a negative pregnancy test (β HCG) before starting treatment, and women and men of childbearing age (who have sexual relations with women of childbearing age) must agree to continuously use effective contraceptive measures during the treatment period and for 6 months after the last treatment dose; 9. Patients with a history of hepatitis B and C can be included in the study, but active hepatitis B patients must start antiviral therapy before starting the study treatment; 10. Participants voluntarily join the study and sign an informed consent form. Exclusion Criteria: 1. Pregnant or lactating women, or those who have the ability to conceive but refuse to take contraceptive measures; 2. History of other malignant tumors within the past 5 years, excluding cervical carcinoma in situ or squamous cell carcinoma of the skin that has been adequately treated, or basal cell carcinoma of the skin that has been largely controlled; 3. Merge other serious uncontrolled diseases (such as individuals with a history of difficult to control mental illness or severe intellectual or cognitive impairment; severe heart failure, angina pectoris, myocardial infarction, arrhythmia, etc.); 4. Pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-related pneumonia, and severe impairment of lung function; 5. Suffering from active, known or suspected autoimmune diseases. Subjects with hypothyroidism who only require hormone replacement therapy and those with skin diseases that do not require systemic treatment may be included; 6. Easy to bleed, at risk of massive hemoptysis, and with a history of significant coagulation dysfunction; 7. Suffering from hypertension and unable to achieve good control with antihypertensive medication (systolic blood pressure ≥ 140mmHg or diastolic blood pressure ≥ 90mmHg); 8. History of immunodeficiency, including HIV testing positive, having other acquired or congenital immunodeficiency diseases, or having a history of organ transplantation and allogeneic bone marrow transplantation; 9. Severe active infections requiring intravenous antibiotic treatment occur during the screening period; 10. Individuals with multiple factors that affect oral medication (such as inability to swallow, post gastrointestinal resection, chronic diarrhea, and intestinal obstruction); 11. Individuals who are allergic to the experimental drug; 12. Patients who cannot comply with the trial protocol or cooperate with follow-up; 13. The researchers believe that participants should not participate in this experiment.

Gender: All

Minimum age: 18 Years

Maximum age: 75 Years

Healthy volunteers: No

Locations:

Facility:
Name: Harbin Medical University

Address:
City: Harbin
Zip: 150081
Country: China

Contact:
Last name: Zhiwei Li, MD

Phone: 86+15004683651
Email: lzhw0451@163.com

Start date: October 2024

Completion date: April 2028

Lead sponsor:
Agency: Harbin Medical University
Agency class: Other

Source: Harbin Medical University

Record processing date: ClinicalTrials.gov processed this data on November 12, 2024

Source: ClinicalTrials.gov page: https://clinicaltrials.gov/ct2/show/NCT06648525