To hear about similar clinical trials, please enter your email below
Trial Title:
Utilizing Long-read Sequencing to Investigate the EGFR Landscape of EGFR Positive Lung Cancer Patients
NCT ID:
NCT06659458
Condition:
Lung Cancer - Non Small Cell
EGFR Exon 19 Deletion Mutation
Conditions: Official terms:
Lung Neoplasms
Conditions: Keywords:
Lung cancer
EGFR gene
Study type:
Interventional
Study phase:
N/A
Overall status:
Not yet recruiting
Study design:
Allocation:
Non-Randomized
Intervention model:
Parallel Assignment
Primary purpose:
Basic Science
Masking:
None (Open Label)
Intervention:
Intervention type:
Other
Intervention name:
blood draw
Description:
A 10ml Blood sample will be taken and used to sequence the EGFR gene and surrounding DNA.
Arm group label:
EGFR Positive Lung Cancer
Arm group label:
Healthy Subjects
Intervention type:
Other
Intervention name:
Gene sequencing
Description:
Subjects will have their DNA sequenced within and around the EGFR gene.
Arm group label:
EGFR Positive Lung Cancer
Arm group label:
Healthy Subjects
Summary:
EGFR gene mutations are some of the most commonly occurring mutations in non-small cell
lung cancer. Investigators have developed a DNA instability model that estimates a risk
score to assess the likelihood of an individual acquiring a cancer-linked mutation. The
aim of this study is to collect blood from both those diagnosed with EGFR positive lung
cancer and healthy individuals, evaluate their gene sequence surrounding the EGFR
landscape and use the cancer positive and healthy sequences to validate the risk
assessment model, which may one day be used to provide insight on susceptibility of
getting EGFR positive lung cancer or potentially other cancer types.
Criteria for eligibility:
Criteria:
Inclusion Criteria:
- 18-100 years old
- Biologically born female
- Diagnosed with EGFR positive lung cancer (Arm 1-Cancer group)
- No cancer diagnosis (Arm 2-health control)
Exclusion Criteria:
- less than 18 years of age
- Biologically born male
- Incarcerated at the time of participation
Gender:
Female
Gender based:
Yes
Gender description:
Biologically born females
Minimum age:
18 Years
Maximum age:
100 Years
Healthy volunteers:
Accepts Healthy Volunteers
Locations:
Facility:
Name:
Our Lady of the Lake Regional Medical Center
Address:
City:
Baton Rouge
Zip:
70808
Country:
United States
Start date:
January 1, 2025
Completion date:
December 31, 2025
Lead sponsor:
Agency:
Our Lady of the Lake Hospital
Agency class:
Other
Source:
Our Lady of the Lake Hospital
Record processing date:
ClinicalTrials.gov processed this data on November 12, 2024
Source: ClinicalTrials.gov page:
https://clinicaltrials.gov/ct2/show/NCT06659458
