Colon cancer patients with higher vitamin D levels do better
9 Jul 2014
New research demonstrates that high levels of vitamin D can help colon cancer patients survive the disease, based on a study of 1,600 patients after surgery.
The study found that those with the highest levels of vitamin D have half the risk of dying of the disease compared with those with the lowest levels. It is the first to correlate the long-term survival prospects of colon cancer patients after diagnosis with total blood levels of vitamin D.
Vitamin D is made in the body when the skin is exposed to sunlight and is found in foods such as fish liver oil, eggs and fatty fish such as salmon, herring and mackerel. It is known to boost the uptake of calcium and bone formation. Some observational studies have also suggested a link between low levels of vitamin D and greater risks of many acute and chronic diseases.
Promising findings, but more trials are necessary
Malcolm Dunlop of the Medical Research Council Human Genetics Unit at the University of Edinburgh who led this study, said it suggested vitamin D supplements may be worth exploring for colon cancer patients. "Our findings are promising but it is important to note that this is an observational study (and) we need carefully designed randomized clinical trials before we can confirm whether taking vitamin D supplements offers any survival benefit," he said.
Colon cancer, also known as colorectal or bowel cancer, is the second most common cancer in Europe with around 447,000 new cases diagnosed in 2012, said the charity Cancer Research UK which funded this study.
Dunlop's team tested blood samples from almost 1,600 patients after surgery for colon cancer. They found the greatest benefit of vitamin D in patients with stage 2 cancers, when the tumor may be quite large but the disease has not yet spread.
75% of the patients with the highest vitamin D levels were still alive after five years, compared with fewer than two thirds of those with the lowest levels, they found.
The team, whose work was published in the Journal of Clinical Oncology, said they now plan to set up a clinical trial to test whether taking vitamin D tablets in combination with chemotherapy can improve colon cancer survival rates.