Comparing two treatments for common type of breast cancer
Comparing two treatments for common type of breast cancer11 Dec 2015
Analysis of patient-reported outcomes, in which anastrozole and tamoxifen were compared in postmenopausal women with ductal carcinoma in-situ (DCIS) (the most common type of non-invasive breast cancer) who underwent lumpectomy plus radiotherapy, found that there were no differences in outcomes related to quality of life but some differences in outcomes related to symptoms in the two treatment groups.
The study confirmed some of the expected outcome differences in symptoms between the two drugs, which included more hot flashes with tamoxifen treatment and more vaginal problems and musculoskeletal complaints with anastrozole treatment.
The patients did not know what medication they were taking
“The phase 3, NSABP B-35 clinical trial enrolled 3,104 postmenopausal women with DCIS that was hormone receptor-positive, and the primary endpoint was to determine whether anastrozole was superior to tamoxifen. Because these two drugs have different side-effect profiles it was important to hear from women about their experiences to add that information to decision making” said Patricia A. Ganz, MD, distinguished professor at UCLA schools of Medicine & Public Health and the Jonsson Comprehensive Cancer Center at UCLA.
Patient-reported outcomes data is information obtained from each patient participating in the trial about her experience with the drug in terms of physical and emotional functioning and various symptoms such as hot flashes, vaginal dryness, muscle and joint aches and pains (symptoms), Ganz explained.
Since this was a double-blind trial, assessments were done without the bias of knowing what medication the women were taking, she added.
“There were no differences in quality of life outcomes”
Ganz and colleagues used data from 1,193 patients enrolled in the patient-reported outcomes portion of the NSABP B- 35 trial. Quality of life and symptom data were collected at baseline prior to randomization to anastrozole or tamoxifen, every six months during the five years of treatment, and 12 months after treatment. Patients were grouped into those younger than 60 years or those 60 years or older. The analysis of the results revealed that:
- Five years after treatment, there were no differences in quality of life outcomes
- The severity of hot flashes was greater in those who received tamoxifen than those who received anastrozole, and this experience varied over time
- The severity of musculoskeletal pain at 6-month to 24- month time points and vaginal problems was greater in those who received anastrozole than those who received tamoxifen
- Sexual functioning was slightly worse for those who received anastrozole compared with those who received tamoxifen
- There was no worsening of physical or emotional health and depression with either drug, and overall, both drugs were found to be safe
- All symptoms were worse in women younger than 60 years than those 60 years or older.
No overall survival difference between the two treatments
In general, anastrozole was found to be slightly but significantly better than tamoxifen in terms of breast cancer-free interval. There was no overall survival difference between the two treatments.
“Both of these drugs are excellent and can reduce the risk for breast cancer recurrence. Physicians and patients need to use this information along with the main trial outcomes to choose the optimal treatment for each woman. This is part of personalized or precision medicine,” Ganz said.Source: eCancer News