Could a breath test detect lung cancer?

10 Sep 2014

Subtle genetic changes can be detected in the vapor given off by cells engineered to mimic the early stages of lung cancer.

This could be used to develop a breath test for the disease, by identifying high-risk patients that could benefit from regular Computed Tomography (CT) scans. It could also detect specific mutations within patients’ tumors that could help guide treatment.

The research was published in the British Journal of Cancer.


A potential way for early diagnosis

The disease has one of the lowest survival rates of any cancer because many patients are diagnosed at a late stage, when it’s not possible to cure them.

The researchers, from the University of Liverpool and the Technion-Israel Institute of Technology, looked at cells taken from the lining of the airways that had been engineered to carry different genetic faults linked to early stage lung cancer. They developed a technique for analyzing the vapor inside the container in which the cells were growing and showed it was capable of distinguishing which of two different genes were faulty in the cells.

Comments from study leaders

Dr Mike Davies at the "University of Liverpool Roy Castle Lung Cancer Research Programme", led the study in collaboration with Professor Hossam Haick at the Technion-Israel Institute of Technology, whose team developed the technology behind the test.

Dr Davies said: “These findings tell us that it’s theoretically possible to develop a test that could diagnose early lung cancer in the breath of patients. There’s an urgent need to diagnose lung cancers earlier, when treatment is more effective. This is a potential step towards developing a handheld device that could aid lung cancer screening and diagnosis. It could also be used to help match patients to the right treatment by providing doctors with a snapshot of the genetic makeup of their individual tumor. But first we need to do further tests with the breath of real patients to see whether this method can accurately diagnose genetic changes in growing lung tumors.”

Nell Barrie, senior science information manager at Cancer Research UK, said: “These early results raise the prospect of a cheap, effective test to diagnose lung cancer. But we’re still a way off from the large scale trials necessary before this technique could be used widely.

“Lung cancer is extremely difficult to treat, but when diagnosed at its earliest stage around 70% of patients will survive their disease for a year or more, compared to 14% when the disease is diagnosed at its most advanced stage. So any test that could potentially diagnose the disease earlier would be good news for patients. In the meantime, anyone with a persistent cough, shortness of breath or blood in their phlegm should see their GP as soon as possible.”


Source: eCancer News

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