Half a million cancer cases per year due to being overweight or obese

26 Nov 2014

A new study shows that nearly 500,000 new cancer cases per year can be attributed to high "body mass index" (BMI, a metric of weight compared to height). The study was led by the International Agency for Research on Cancer (IARC). IARC is the cancer agency of the World Health Organization (WHO).

The study, published in The Lancet Oncology, highlights that being overweight or obese has become a major risk factor, responsible for an estimated 3.6% (481,000) of all new cancer cases in 2012.

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Striking global disparities

Global analysis shows that cancer due to being overweight or obese is currently far more common in more developed countries (393,000 cases, 5.2% of all new cancer cases in these countries) than in less developed countries (88,000 cases, 1.5% of all new cancer cases in these countries).

North America remains the most affected, with an estimated 111,000 obesity-related cancers in 2012, accounting for 23% of the total global cancer burden linked to high BMI.

In Europe, the proportion of cancers due to high BMI is also large, particularly in eastern Europe (65,000 cases, 6.5% of all new cancer cases in the region).

Overall, the countries with the highest cancer burden attributable to weight and obesity in men are the Czech Republic (5.5% of the country’s new cancer cases), Jordan (4.5%), the United Kingdom (4.4%), and Malta (4.4%).

Among women, Barbados (12.7%), the Czech Republic (12.0%), and Puerto Rico (11.6%) are most affected.

In the USA, one of the largest contributors of global cancers associated with high BMI, 3.5% and 9.5% of the country’s new cancer cases are linked to excess body weight in men and women, respectively.

Although in most Asian countries the proportion of cancers associated with overweight and obesity is not large, it still translates into a considerable absolute number of cases, due to the large population size. For example, in China, about 50,000 cancer cases in women and men are associated with excess weight and obesity, accounting for 1.6% of the country’s new cancer cases.

In contrast, the contribution of excess weight and obesity to cancer burden remains low in Africa (7300 cases, 1.5% of all new cancer cases in the continent).

“Overall, we see that while the number of cancer cases associated with excess weight and obesity remains highest in richer countries, similar effects are already visible in parts of the developing world,” says Dr Isabelle Soerjomataram, one of the study’s lead authors and the project’s principal investigator.

Women are more affected

High BMI is a known risk factor for cancers of the esophagus, colon, rectum, kidney, pancreas, gallbladder, postmenopausal breast, ovary, and endometrium, as well as for other non-communicable diseases, notably cardiovascular disease and diabetes.

The study highlights that the proportion of cancers related to obesity is higher in women than in men, with population attributable fractions of 5.3% and 1.9%, respectively.

“Women are disproportionately affected by obesity-related cancers,” says IARC’s Dr Melina Arnold, one of the study’s lead authors, “For example, for postmenopausal breast cancer, the most common cancer in women worldwide, the study suggests that 10% of these cancers could have been prevented by having a healthy body weight.”

Cancers of the endometrium, colon, and breast account for almost three quarters (73%) of all cancers linked to high BMI in women.

In men, kidney and colon cancers together account for two thirds (66%) of all cancers associated with high BMI.

Potential for prevention

“These worrying results highlight that it’s crucial to maintain a healthy weight to prevent so many common cancers,” says Dr Kate Allen, Executive Director of Science and Public Affairs at World Cancer Research Fund International, which funded the project.

“In the United Kingdom, 13,000 cases diagnosed in 2012 in women (8.2% of all cancers) could be ascribed to overweight and obesity. It’s also alarming to see that men in the UK are fourth in the world in this obesity cancer league table, with 6,000 cases (4.4% of all cancers) attributed to being overweight or obese. Cancer is an epidemic problem, and to tackle it we need to help people take measures to be a healthy weight.”

Reducing excess weight and obesity at the population level could have significant health benefits, including reducing the burden of cancer.

The study also shows that 1/4 of all cancers attributable to excess weight and obesity worldwide (118,000 cases) could have been prevented if populations had simply maintained their average BMI of 30 years ago.

Efficient weight control measures must be put in place

“The number of cancers linked to obesity and overweight is expected to rise globally along with economic development,” says Dr Christopher Wild, Director of IARC. “This study stresses the importance of putting in place efficient weight control measures, to curb the high number of cancers associated with excess body weight and to avoid the problems faced by rich countries being repeated in those now undergoing rapid development.”

Source: International Agency for Research on Cancer
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