Shorter and intensive radiotherapy: safe in early prostate cancer

Shorter and intensive radiotherapy: safe in early prostate cancer

5 Apr 2016

Giving early-stage prostate cancer patients a slightly higher daily dose of radiation can cut more than two weeks from the current treatment regimen without compromising cancer control, according to a national study led by a Duke Cancer Institute researcher.

Implications for public health policy

Publishing April 4 in the Journal of Clinical Oncology, the research team compared the shortened radiation therapy schedule of about 5.5 weeks to the standard 8-week regimen to determine if rates of cure were similar. Both treatment schedules were similar in terms of controlling cancer, but doctors reported slightly more mild side effects in patients getting the shorter radiation schedule.

"This study has implications for public policy," said the study's principal investigator, W. Robert Lee, M.D., a professor in the Department of Radiation Oncology at Duke. "Because the shorter regimen has advantages such as greater patient convenience and lower costs, it's important to establishing whether we can cure as many patients with the shorter regimen. Our study provides that information for the first time."

“No differences were observed in more severe side effects”

Lee and colleagues, working as part of NRG Oncology, a non-profit cancer research organization, enrolled about 1,100 men whose prostate cancer was diagnosed early, before it had spread. Roughly half the patients were randomly assigned to receive the typical regimen of 41 treatments; the other half received the higher dose over just 28 treatments.

At five years, scientists reported that:

• Disease-free survival was no different between the two groups, with 85.3% of men in the traditional group being cancer-free, compared to 86.3% of men in the shorter regimen group.
• Overall survival at five years was also no different, at 93.2% and 92.5% respectively.
• Mild gastrointestinal and genitourinary toxicity as reported by doctors was observed more frequently in patients getting the higher daily dose, shorter frequency radiation, but no differences were observed in more severe side effects, which were rare (less than 5%) with either regimen.

The researchers also asked patients to describe their own experiences of side-effects, but these data have yet to be analyzed. "These findings should help guide clinical decisions, and doctors should be comfortable recommending a shorter radiotherapy course as an alternative to the conventional schedule."

Source: eCancer News