Surgical resection induces better responses in melanoma patients

9 Oct 2015

A new study shows that in an era of systemic medical therapy for metastatic melanoma, surgical treatment in selected patients provides a better survival rate than medical treatment alone.

Surgical removal of melanoma that has metastasized, or spread, to the abdomen appears to help patients live more than twice as long as those who receive only medical therapy, according to the results of a new study. In more than 1,600 patients treated over 45 years, the results showed an overall survival benefit from surgical treatment despite recent advances in systemic drugs to treat metastatic melanoma.

According to lead author Gary B. Deutsch, MD, MPH, a surgical oncologist at North Shore -LIJ Health System in New York, the research is the first comprehensive study of all major abdominal locations of melanoma metastases conducted to assess trends in surgical management and overall survival.

The patients had operable metastases

In this study of 1,623 patients from the John Wayne Cancer Institute, overall survival (also called survival) was defined as how long the patient lived after diagnosis of stage IV (metastatic) melanoma. By measuring survival from this point, the researchers eliminated any variability in disease-free interval (time from treatment until the first cancer recurrence) that can occur in patients with metastatic melanoma, Dr. Deutsch said.

All patients had abdominal metastases that might be operable and were referred for surgical evaluation. The metastases were located in:

  • The liver as the sole site of cancer spread in 697 patients;
  • The gastrointestinal (GI) tract in 336;
  • The adrenal glands, in 138;
  • The spleen, in 109; and
  • The pancreas, in 38
  • Another 305 patients had multiple sites of abdominal metastases
  • Metastases in 104 patients resulted from ocular melanoma rather than skin cancer.

Nearly one in four patients (392 of 1,623) underwent surgical resection of the metastasis, or "metastasectomy." The operation was performed alone, combined with medical therapy, or in some cases, included radiofrequency ablation or heat probe treatment to destroy cancer cells.

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Very promising results especially for patients with GI tract metastases

When the investigators combined all abdominal locations of melanoma metastasis, they found that the surgical group's median survival was 18 months compared to only seven months for the nonsurgical group of 1,231 patients.

In this study, individuals with GI tract metastases who underwent complete, curative resection had the longest median survival of any patients--more than two years--Dr. Deutsch reported. "Surgical resection can really make a difference in the patients with GI tract metastases" said Anton J. Bilchik, MD, PhD, FACS, the study's senior investigator and a professor of surgery and chief of medicine at the John Wayne Cancer Institute. "The operation can be performed laparoscopically, so it is minimally invasive."

Even patients with GI tract metastases who underwent palliative surgical resection to improve symptoms, such as bleeding and pain, had a slightly longer survival than patients who had no operation, Dr. Bilchik noted.

"With our long-term follow-up, we believe that select patients can live longer with surgical treatment," Dr. Deutsch said.

A possibility to cure metastatic melanoma combining surgical resection with medical therapy

To determine whether treatment era affected survival, the investigators divided patients into groups of before (1969 to 2003) and after (2003 to 2014) advances in systemic therapy. The latter group contained 320 patients. Contrary to what the researchers expected, treatment in the era of more effective systemic immunotherapy did not significantly affect survival compared to earlier treatment, Dr. Bilchik added.

"Despite new immunotherapies, surgical resection provides the longest survival in patients with abdominal metastatic melanoma," Dr. Bilchik said. "There is so much excitement about the new systemic immunotherapies, but there needs to continue to be multidisciplinary tumor boards to decide when to intervene surgically."

Both Dr. Bilchik and Dr. Deutsch said surgical resection combined with medical therapy offers the chance to cure metastatic melanoma in selected patients. Patients may be candidates for curative surgical resection, according to Dr. Deutsch, if they have a long disease-free interval and a slow tumor doubling time (time in which the tumor doubles in size), and are otherwise healthy.

 

 

Source: Medical News Today
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